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Pathogens
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SARS-CoV-2 Replication and Pathogenesis
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Topical Collection "SARS-CoV-2 Replication and Pathogenesis"

A topical collection in Pathogens (ISSN 2076-0817). This collection belongs to the section "Viral Pathogens".

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Editors

Dr. Makoto Takeda
E-Mail Website
Collection Editor
National Institute of Infectious Diseases, Tokyo, Japan
Interests: respiratory viruses; proteolytic activation of viral glycoprotein; virus–host interaction; virus receptors; molecular mechanism of virus replication
Prof. Dr. Wataru Kamitani

E-Mail Website
Collection Editor
Department of Infectious Diseases and Host Defense, Gunma University, Gunma, Japan
Interests: coronavirus; reverse genetics system; virus replication and pathogenesis

Topical Collection Information

Dear Colleagues,

SARS-CoV-2—a novel coronavirus that emerged in Wuhan, China at the end of 2019—quickly spread around the world, causing a pandemic that will be long remembered in human history. The modern social system is one of the causes of this pandemic. On the other hand, scientific methods and analyses have improved remarkably, with vast amounts of research results being published every day. In addition, vaccines have been developed in only a year or so and have already been administered more than 10 billion times around the world. Thorough analysis of this virus will reveal the mechanism of its emergence and provide a basis for the development of theoretical antiviral agents and vaccines. It will also contribute to the risk assessment of SARS-CoV-2-related viruses in animals, and may prevent another pandemic from occurring. Therefore, in this Topical Collection, we focus on the molecular bases of multiplication and virulence of SARS-CoV-2 and related viruses. We welcome submissions of original articles on mechanisms of viral entry, membrane fusion, RNA synthesis, innate immune evasion, functions of nonstructural and accessory proteins, structural analysis of viral proteins and antibodies, pathological features, analysis of animal models, analysis of variants, mechanisms of action of antiviral agents, escape from vaccines or antiviral agents, and so on. We also welcome well-focused, high-quality review articles on these topics.

Dr. Makoto Takeda
Prof. Dr. Wataru Kamitani
Collection Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the collection website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pathogens is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • SARS-CoV-2
  • COVID-19
  • coronavirus
  • virus entry
  • viral RNA synthesis
  • vaccine
  • variant

Published Papers (1 paper)

2022

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Article
Hydrophobic Alpha-Helical Short Peptides in Overlapping Reading Frames of the Coronavirus Genome
by
Takashi Okura
,
Kazuya Shirato
,
Masatoshi Kakizaki
,
Satoko Sugimoto
,
Shutoku Matsuyama
,
Tomohisa Tanaka
,
Yohei Kume
,
Mina Chishiki
,
Takashi Ono
,
Kohji Moriishi
,
Masashi Sonoyama
,
Mitsuaki Hosoya
,
Koichi Hashimoto
,
Katsumi Maenaka
and
Makoto Takeda
Pathogens 2022, 11(8), 877; https://doi.org/10.3390/pathogens11080877 - 03 Aug 2022
Viewed by 1370
Abstract
In this study, we show that the coronavirus (CoV) genome may encode many functional hydrophobic alpha-helical peptides (HAHPs) in overlapping reading frames of major coronaviral proteins throughout the entire viral genome. These HAHPs can theoretically be expressed from non-canonical sub-genomic (sg)RNAs that are [...] Read more.
In this study, we show that the coronavirus (CoV) genome may encode many functional hydrophobic alpha-helical peptides (HAHPs) in overlapping reading frames of major coronaviral proteins throughout the entire viral genome. These HAHPs can theoretically be expressed from non-canonical sub-genomic (sg)RNAs that are synthesized in substantial amounts in infected cells. We selected and analyzed five and six HAHPs encoded in the S gene regions of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and Middle East respiratory syndrome coronavirus (MERS-CoV), respectively. Two and three HAHPs derived from SARS-CoV-2 and MERS-CoV, respectively, specifically interacted with both the SARS-CoV-2 and MERS-CoV S proteins and inhibited their membrane fusion activity. Furthermore, one of the SARS-CoV-2 HAHPs specifically inhibited viral RNA synthesis by accumulating at the site of viral RNA synthesis. Our data show that a group of HAHPs in the coronaviral genome potentially has a regulatory role in viral propagation. Full article
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