Transcriptomic Changes in the Human Airway Epithelium during Respiratory Viral Infection
A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Viral Pathogens".
Deadline for manuscript submissions: 31 August 2024 | Viewed by 2421
Special Issue Editor
Interests: broadly protective vaccines; therapeutics against infectious human and animal viral diseases; molecular pathogenesis of emerging and zoonotic infectious viruses including influenza A viruses
Special Issue Information
Dear Colleagues,
The current era of science is influenced by two paradoxical events—one being emerging and re-emerging respiratory RNA viruses such as influenza and SARS-CoV, which are major global health threats, and the other the revolutionary technology of whole-transcriptome analysis with total RNA sequencing, resulting in a deeper understanding of the transcriptional regulations of gene expressions in health and disease. The human nasal epithelium is a primary site of exposure to respiratory viral pathogens and is ideal for understanding the dynamics of host responses against respiratory viral infection. Reports have shown that transcriptional upregulation in the nasal epithelium during experimental infections with respiratory viruses, i.e., influenza, SARS-CoV-2, SARS-CoV, and MERS-CoV, was induced by these viruses in the early stages of infection and that it altered host genes, with increased cytokine production and virus-specific host antiviral responses. These molecular events, which are initiated in the infected nasal epithelium, may adversely impact the airway, and the associated genes identified could provide new therapeutic perspectives regarding the targeting of host factors that viruses depend on.
This Special Issue on “Transcriptomic Changes in the Human Airway Epithelium during Respiratory Viral Infection” welcomes study reports and review articles in the form of human airway epithelial cell model-based thematic approaches, extended hypothetical models, collective real-time patient dataset outcomes of single, extensive, or multiple respiratory viral infections with analyses, experimentally established transcriptional signatures serving as biomarkers, regional tissue-specific or systemic therapeutic approaches based on these transcriptional dynamics, and future directions regarding prophylactic measures.
Dr. Mookkan Prabakaran
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pathogens is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- respiratory viral infections
- transcriptional signatures
- virus–host interactions
- human airway epithelium
- extended models