Special Issue "Chronic Wasting Disease and Other Animal Prion Diseases: Towards the Comprehension of Animal Prion Pathologies"
Deadline for manuscript submissions: closed (30 October 2023) | Viewed by 557
Interests: prion diseases; chronic wasting disease; scrapie; bovine spongiform encephalopathy; PrP; pathology
Interests: chronic wasting disease; animals; prion proteins
2. Anatomical Pathology, Department of Pathology and Laboratory Medicine, Institute of Eastern Ontario Regional Laboratory Association, Ottawa Hospital Civic Location, Ottawa, ON K1Y 4E9, Canada
Interests: CNS pathogens; prions; Creutzfeldt-Jakob disease; surveillance
Prion diseases are neurodegenerative, fatal processes of animals and humans caused by prions, which are infectious, aberrant proteins that can propagate in the absence of genetic material. Along with scrapie, the prion disease of sheep and goats, Chronic Wasting Disease (CWD), which affects numerous species of cervids, stands out for being highly transmissible. CWD is unique among prion diseases since it is the only one found in both wild and domestic animals.
Many aspects of prion diseases remain to be elucidated. These include the specific molecular mechanisms involved in their pathogenesis or which molecules could be used as biomarkers for a preclinical diagnosis or treatment. However, one of the most puzzling features about prions is that, like other pathological agents, exist in a variety of strains that produce different disease phenotypes and have different host ranges. Since prions do not contain genetic material, the biological information of prion strains it is believed to be encoded in, and perpetuated by, their conformation.
This Special Issue welcomes prion researchers who wish to share new developments in CWD and other animal prion diseases. Original research and review articles about animal prion strains, pathogenesis, possible biomarkers for diagnosis and potential therapeutic approaches to prion diseases are especially welcomed.
Dr. Alicia Otero
Dr. Alsu Kuznetsova
Dr. Gerard H. Jansen
Manuscript Submission Information
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- prion diseases
- animal prions
- prion pathogenesis
- prion strains