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Pathogens
Special Issues
Antigen Presenting Cells in Disease Pathogenesis
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Special Issue "Antigen Presenting Cells in Disease Pathogenesis"

A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Immunological Responses and Immune Defense Mechanisms".

Deadline for manuscript submissions: 31 January 2024 | Viewed by 1842

Special Issue Editors

Dr. Shisong Jiang

E-Mail Website
Guest Editor
Department of Oncology, University of Oxford, Oxford OX3 7DQ, UK
Interests: understanding mechanisms of antigen presentation to the immune system; biomarker discovery and the development of new vaccines, including therapeutic vaccines with a particular emphasis on translating discoveries into new treatments for cancer patients
Prof. Dr. Hinh Ly

E-Mail Website
Guest Editor
Department of Veterinary & Biomedical Sciences, University of Minnesota, Twin Cities, MN, USA
Interests: hemorrhagic fever viruses; arenaviruses; lassa fever; host-virus interactions; innate immunity; viral pathogenesis and host defense
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Antigen-presenting cells (APCs) such as dendritic cells (DCs) and macrophages are key in bridging innate immunity to adaptive immunity and activating specific immune responses to clear invaded pathogens and malignancies. However, under certain situations, these cells may play a pathogenic role leading to diseases which can be lethal. Understanding the mechanisms of APCs pathogenesis may help to develop diagnosis and therapeutics for these diseases.

In this Special Issue, we encourage researchers to submit a manuscript (original research articles, reviewers, opinions, short communications) that focuses on the role of APCs in disease pathogenesis and/or targets APCs as diagnosis and therapeutics. 

Dr. Shisong Jiang
Prof. Dr. Hinh Ly
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pathogens is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antigen presenting cells
  • pathogenesis
  • autoimmune diseases
  • infectious diseases
  • cancer

Published Papers (1 paper)

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Review

12 pages, 907 KiB  
Review
Roles of FcRn in Antigen-Presenting Cells during Autoimmunity and a Clinical Evaluation of Efgartigimod as an FcRn Blocker
by
Yihan Zhou
and
Shisong Jiang
Pathogens 2023, 12(6), 817; https://doi.org/10.3390/pathogens12060817 - 08 Jun 2023
Viewed by 1568
Abstract
The immune system is a complex network of multiple cells, tissues, and organs that protects the body against foreign pathogenic invaders. However, the immune system may mistakenly attack healthy cells and tissues due to the cross-reactivity of anti-pathogen immunity, leading to autoimmunity by [...] Read more.
The immune system is a complex network of multiple cells, tissues, and organs that protects the body against foreign pathogenic invaders. However, the immune system may mistakenly attack healthy cells and tissues due to the cross-reactivity of anti-pathogen immunity, leading to autoimmunity by autoreactive T cells and/or autoantibody-secreting B cells. Autoantibodies can accumulate, resulting in tissue or organ damage. The neonatal crystallizable fragment receptor (FcRn) is an important factor in immune regulation through controlling the trafficking and recycling of immunoglobulin G (IgG) molecules, the most abundant antibody in humoral immunity. In addition to its role in IgG trafficking and recycling, FcRn is also involved in antigen presentation, which is a crucial step in the activation of the adaptive immune response via directing the internalization and trafficking of antigen-bound IgG immune complexes into compartments of degradation and presentation in antigen-presenting cells. Efgartigimod, an FcRn inhibitor, has shown promise in reducing the levels of autoantibodies and alleviating the autoimmune severity of myasthenia gravis, primary immune thrombocytopenia, and pemphigus vulgaris/foliaceus. This article aims to provide an overview of the importance of FcRn in antigen-presenting cells and its potential as a therapeutic target in autoimmune diseases, using efgartigimod as an example. Full article
(This article belongs to the Special Issue Antigen Presenting Cells in Disease Pathogenesis)
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