Special Issue "The Use of Insect Organisms to Study Human Pathogenic Fungi"
Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 129
Interests: insect immunity; antimicrobial peptides; Galleria mellonella; host–pathogen interaction
Pathogenic fungi pose a threat to human health and life, especially immunocompromised patients, including those after transplants and cancer patients. Therefore, a number of studies are carried out to understand host–fungal pathogen interactions, elucidate the course of infection, and determine the virulence factors of fungi. The search for novel antifungal compounds is also an important area. Often, in vitro tests are insufficient as they do not coincide with the results obtained in vivo. Due to high costs and logistical and ethical problems, research using small mammals, such as mice and rats, is limited.
Therefore, insects such as Galleria mellonella (Lepidoptera), Drosophila melanogaster (Diptera), Bombyx mori (Lepidoptera), or the mosquito Culex quinquefasciatus (Diptera) have been widely used as alternative non-mammalian models for the study of fungal virulence and pathogenesis. Importantly, G. mellonella caterpillars can be kept at 37 ºC, which is physiological for the human body.
Research with the use of insect model organisms allows observing the development of infection in a living organism and determining the lethal doses of a given pathogen. Moreover, it enables testing the efficacy of conventional and novel antifungal drugs and determination of their dosage. It also provides information on the safety profile of novel antimycotics.
We would like to invite colleagues who study insect host–fungal pathogen interactions and virulence factors of fungi that are pathogenic for humans, as well as testing new antimycotics on insect model organisms, to submit their manuscripts for this Special Issue in the form of original research and reviews.
Dr. Sylwia Stączek
Dr. Agnieszka Zdybicka-Barabas
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pathogens is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- insect model organism
- fungal infections
- animal model
- Galleria mellonella
- fungal pathogens
- innate immunity
- immune response
- antimicrobial peptides
- antifungal peptides