Advances in the Research on Porphyromonas gingivalis Infection
A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Bacterial Pathogens".
Deadline for manuscript submissions: closed (31 January 2024) | Viewed by 1567
Special Issue Editors
Interests: periodontal disease; gingivitis
Interests: Porphyromonas gingivalis; periodontal disease; two-component regulatory system; fimbriae
Special Issue Information
Dear Colleagues,
Periodontitis is a prevalent, chronic inflammatory disease associated with a dysbiotic subgingival plaque that causes periodontal tissue destruction, often leading to tooth loss. Porphyromonas gingivalis, a keystone pathogen implicated in severe forms of periodontitis, expresses various virulence factors, including fimbriae, cysteine proteinases, hemagglutinins, and lipopolysaccharides, that together support its pathogenicity and biofilm formation. P. gingivalis invades periodontal tissues by colonizing the gingival sulcus and proliferating in the subgingival plaque by regulating a panel of virulence factors. It evades the host defense mechanisms by deregulating innate immune and inflammatory responses. In addition, bacterial cells and their products can enter blood circulation and contribute to the development and severity of systemic diseases, such as diabetes, rheumatoid arthritis, cardiovascular diseases, and preterm delivery.
In this Special Issue, we invite all submissions (original research article, review article, or short communication) related to the pathogenesis of P. gingivalis, including not only the microbiological and cellular aspects of P. gingivalis infections but also its clinical, immunological, and methodological aspects.
Prof. Dr. Yoshiaki Hasegawa
Dr. Kiyoshi Nishikawa
Guest Editors
Manuscript Submission Information
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Keywords
- Porphyromonas gingivalis
- periodontitis
- periodontal pathogens
- virulence factor
- periodontal disease