Advances in the Research on Porphyromonas gingivalis Infection

A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Bacterial Pathogens".

Deadline for manuscript submissions: closed (31 January 2024) | Viewed by 1567

Special Issue Editors

Department of Microbiology, School of Dentistry, Aichi Gakuin University, Nagoya 470-0131, Japan
Interests: periodontal disease; gingivitis
Department of Microbiology, School of Dentistry, Aichi Gakuin University, Nagoya 470-0131, Japan
Interests: Porphyromonas gingivalis; periodontal disease; two-component regulatory system; fimbriae

Special Issue Information

Dear Colleagues,

Periodontitis is a prevalent, chronic inflammatory disease associated with a dysbiotic subgingival plaque that causes periodontal tissue destruction, often leading to tooth loss. Porphyromonas gingivalis, a keystone pathogen implicated in severe forms of periodontitis, expresses various virulence factors, including fimbriae, cysteine proteinases, hemagglutinins, and lipopolysaccharides, that together support its pathogenicity and biofilm formation. P. gingivalis invades periodontal tissues by colonizing the gingival sulcus and proliferating in the subgingival plaque by regulating a panel of virulence factors. It evades the host defense mechanisms by deregulating innate immune and inflammatory responses. In addition, bacterial cells and their products can enter blood circulation and contribute to the development and severity of systemic diseases, such as diabetes, rheumatoid arthritis, cardiovascular diseases, and preterm delivery.

In this Special Issue, we invite all submissions (original research article, review article, or short communication) related to the pathogenesis of P. gingivalis, including not only the microbiological and cellular aspects of P. gingivalis infections but also its clinical, immunological, and methodological aspects.

Prof. Dr. Yoshiaki Hasegawa
Dr. Kiyoshi Nishikawa
Guest Editors

Manuscript Submission Information

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Keywords

  • Porphyromonas gingivalis
  • periodontitis
  • periodontal pathogens
  • virulence factor
  • periodontal disease

Published Papers (1 paper)

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Review

28 pages, 4272 KiB  
Review
Photoinactivation and Photoablation of Porphyromonas gingivalis
by David M. Harris and John G. Sulewski
Pathogens 2023, 12(9), 1160; https://doi.org/10.3390/pathogens12091160 - 14 Sep 2023
Viewed by 1254
Abstract
Several types of phototherapy target human pathogens and Porphyromonas gingivitis (Pg) in particular. The various approaches can be organized into five different treatment modes sorted by different power densities, interaction times, effective wavelengths and mechanisms of action. Mode 1: antimicrobial ultraviolet [...] Read more.
Several types of phototherapy target human pathogens and Porphyromonas gingivitis (Pg) in particular. The various approaches can be organized into five different treatment modes sorted by different power densities, interaction times, effective wavelengths and mechanisms of action. Mode 1: antimicrobial ultraviolet (aUV); mode 2: antimicrobial blue light (aBL); mode 3: antimicrobial selective photothermolysis (aSP); mode 4: antimicrobial vaporization; mode 5: antimicrobial photodynamic therapy (aPDT). This report reviews the literature to identify for each mode (a) the putative molecular mechanism of action; (b) the effective wavelength range and penetration depth; (c) selectivity; (d) in vitro outcomes; and (e) clinical trial/study outcomes as these elements apply to Porphyromonas gingivalis (Pg). The characteristics of each mode influence how each is translated into the clinic. Full article
(This article belongs to the Special Issue Advances in the Research on Porphyromonas gingivalis Infection)
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