Identification and Antifungal Therapy of Candida auris

A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Fungal Pathogens".

Deadline for manuscript submissions: 31 July 2024 | Viewed by 72

Special Issue Editor


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Guest Editor
Medical Microbiology, Clinical Centre, University of Debrecen, Nagyerdei krt. 98, 4032 Debrecen, Hungary
Interests: antifungal susceptibility testing; antifungal pharmacodynamics; epidemiology of Candida species; animal models
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Special Issue Information

Dear Colleagues,

Candida auris is a critical-priority fungi according to the World Health Organization. It was first discovered in a woman's ear in Japan in 2009, but within 10 years, it has spread quickly across the globe. C. auris can be misidentified as other types of fungi unless specialized laboratory technology is used. This misidentification might lead to a patient getting the wrong treatment. C. auris spreads easily in hospitals and nursing homes among people who are already sick, have lines, tubes and drains entering their body and previously received antibiotics or antifungals.

C. auris isolates found across the globe have been genetically grouped into six clades. Clades are important because the susceptibility of C. auris isolates to antifungal drugs is variable and can depend on the clade. The resistant rate to fluconazole is high, and to amphotericin B it is lower. Currently, echinocandins are the recommended initial therapy for the treatment of invasive C. auris infections. The clade-specific mortality is still high, especially among patients with COVID-19-associated infections where a mortality rate of 66% was noticed  in the South American clade.

Prof. Dr. László Majoros
Guest Editor

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Keywords

  • epidemiology
  • clade-specific virulence
  • clinical outcome
  • new therapeutic strategies

Published Papers

This special issue is now open for submission.
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