Organoids in Organ-on-Chip Approach

A special issue of Organoids (ISSN 2674-1172).

Deadline for manuscript submissions: closed (15 December 2022) | Viewed by 5944

Special Issue Editors

Faculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, 00-664 Warsaw, Poland
Interests: lab-on-chip; polymer microfabrication technologies; integrated microchips with optical and electrochemical detection; point of care tools; organ-on-chip; tools for drug screening; toxicology research; nanomaterials
Faculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, 00-664 Warszawa, Poland
Interests: cell-on-chip; organ-on-a-chip; tumor micro-environment; multi-organ-on-chip; cancer research; metastasis; cellular response to cancer therapy; nanomaterials in anticancer studies; liver toxicology

Special Issue Information

Dear Colleagues,

Organ-on-Chip (OoC) models present new possibilities in reproducing the physiological and pathological states of the human body. Models of this type show great potential in better summarizing the main characteristics of real human organs in terms of organ-specific cell types, tissue architecture and function. Moreover, OoC models are an alternative to conventional monolayer cell culture and animal models in biomedical research, while filling the gap between a single cell and an organism in model systems of human physiological and pathological states. In addition, the combination of OoC techniques with organoids can serve as personalized disease models in precision medicine, e.g., in revealing disease mechanisms, testing personalized clinical therapies and in evaluating drug candidates.

The aim of this Special Issue of Organoids is to present new reports that advance knowledge regarding the use of organoids in Organ-on-Chip systems. We welcome the submission of scientific articles and reviews that focus on aspects of organ modeling, disease modeling or drug screening examples using these two approaches.

Prof. Dr. Zbigniew Brzozka
Dr. Agnieszka Żuchowska
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Organoids is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • organoid
  • organ-on-chip
  • drug screening
  • organ in vitro
  • 3D cell culture
  • microfluidic
  • organ modeling

Published Papers (1 paper)

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Review

16 pages, 1441 KiB  
Review
Why Can Organoids Improve Current Organ-on-Chip Platforms?
by Patrycja Sokolowska, Agnieszka Zuchowska and Zbigniew Brzozka
Organoids 2022, 1(1), 69-84; https://doi.org/10.3390/organoids1010007 - 24 May 2022
Cited by 3 | Viewed by 5087
Abstract
Preclinical studies are the first stage of introducing a new potential drug to the pharmaceutical market. Many of the compounds with promising results approved in the preclinical stage show poor prognosis during the first stage of clinical studies, which is connected with inadequate [...] Read more.
Preclinical studies are the first stage of introducing a new potential drug to the pharmaceutical market. Many of the compounds with promising results approved in the preclinical stage show poor prognosis during the first stage of clinical studies, which is connected with inadequate in vitro and in vivo models used in this stage. Both basic in vitro models, and in vivo animal models do not represent the human conditions. Therefore, scientists work on creating an appropriate model that will highly reproduce the characteristics of the human body. The solution could be an organoids model: a laboratory-produced human miniature organ, grown in a specially designed Organ-on-Chip microfluidic tools. This review focuses on characterizing the 3D cell culture types, focusing mainly on organoids, the Organ-on-Chip approach, and presenting the latest reports about the application of their combination in biological research, including toxicological studies. Full article
(This article belongs to the Special Issue Organoids in Organ-on-Chip Approach)
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