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Organoids
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Organoids Mimicking Articular Tissue
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Organoids Mimicking Articular Tissue

A special issue of Organoids (ISSN 2674-1172).

Deadline for manuscript submissions: closed (15 August 2022) | Viewed by 7656

Special Issue Editors

Prof. Dr. Christian Jorgensen

E-Mail Website
Guest Editor
Centre Hospitalier Universitaire de Montpellier, Montpellier, France
Interests: MSC; immunotherapies; Treg; EV; biotherapies; 3D bioprinting
Special Issues, Collections and Topics in MDPI journals
Dr. Farida Djouad

E-Mail Website
Guest Editor
IRMB, University of Montpellier, INSERM, 34295 Montpellier, France
Interests: models for osteoarthritis; autoimmune arthritis

Special Issue Information

Dear Colleagues,

The current Special Issue invites contributions from researchers working in the field of tissue engineering and organoids, with a focus on musculoskeletal diseases, to publish their research on organoids mimicking joint tissue organization. These models can combine various cell types participating in joint pathophysiology. Moreover, different strategies may be applied, including the use of microfluid systems or specifically designed microwells. Furthermore, submissions for research in the fields of imaging analysis and biomechanical studies are highly encouraged.

We look forward to receiving your contributions, which highlight and emphasize the research in the field of organoids.

Prof. Dr. Christian Jorgensen
Dr. Farida Djouad
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Organoids is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • organoids
  • micromass
  • 3D printing
  • cartilage engineering

Published Papers (2 papers)

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Research

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14 pages, 5301 KiB  
Article
Articular Tissue-Mimicking Organoids Derived from Mesenchymal Stem Cells and Induced Pluripotent Stem Cells
by Zhong Alan Li, Jiangyinzi Shang, Shiqi Xiang, Eileen N. Li, Haruyo Yagi, Kanyakorn Riewruja, Hang Lin and Rocky S. Tuan
Organoids 2022, 1(2), 135-148; https://doi.org/10.3390/organoids1020011 - 14 Nov 2022
Cited by 6 | Viewed by 2647
Abstract
Organoids offer a promising strategy for articular tissue regeneration, joint disease modeling, and development of precision medicine. In this study, two types of human stem cells—primary mesenchymal stem cells (MSCs) and induced pluripotent stem cells (iPSCs)—were employed to engineer organoids that mimicked bone, [...] Read more.
Organoids offer a promising strategy for articular tissue regeneration, joint disease modeling, and development of precision medicine. In this study, two types of human stem cells—primary mesenchymal stem cells (MSCs) and induced pluripotent stem cells (iPSCs)—were employed to engineer organoids that mimicked bone, cartilage and adipose tissue, three key tissue components in articular joints. Prior to organoidogenesis, the iPSCs were first induced into mesenchymal progenitor cells (iMPCs). After characterizing the MSCs and iMPCs, they were used to generate cell-embedded extracellular matrix (ECM) constructs, which then underwent self-aggregation and lineage-specific differentiation in different induction media. Hydroxyapatite nanorods, an osteoinductive bioceramic, were leveraged to generate bone and osteochondral organoids, which effectively enhanced mineralization. The phenotypes of the generated organoids were confirmed on the basis of gene expression profiling and histology. Our findings demonstrate the feasibility and potential of generating articular tissue-recapitulating organoids from MSCs and iPSCs. Full article
(This article belongs to the Special Issue Organoids Mimicking Articular Tissue)
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Review

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19 pages, 1597 KiB  
Review
Meniscus Repair: From In Vitro Research to Patients
by Hélène Vignes, Guillaume Conzatti, Guoqiang Hua and Nadia Benkirane-Jessel
Organoids 2022, 1(2), 116-134; https://doi.org/10.3390/organoids1020010 - 02 Nov 2022
Cited by 2 | Viewed by 4514
Abstract
Walking, running, jumping, or even just standing up are habits that we all have to perform in our everyday lives. However, defects in tissues composing the knee joint can drastically alter our ability to complete those simple actions. The knee joint is made [...] Read more.
Walking, running, jumping, or even just standing up are habits that we all have to perform in our everyday lives. However, defects in tissues composing the knee joint can drastically alter our ability to complete those simple actions. The knee joint is made up of the interaction between bones (femur, tibia, and patella), tendons, ligaments, and the two menisci (lateral and medial) in order to ensure smooth body movements. The meniscus corresponds to a crescent-shaped fibrocartilaginous tissue, which is found in the knee joint between the femoral condyles and the tibial plateau. It plays a key role in the stability of the knee joint. However, it is quite vulnerable and therefore tears can occur within this tissue and compromise the proper function of the knee. Recently, numerous efforts have been made in order to find solutions to repair and regenerate the meniscus, supported by both bioengineering researchers and orthopedic surgeons. However, due to its poor healing capacity and its complex structure, the reconstruction of the meniscus remains particularly challenging. In this review, the current treatment options will be explained and the possibility of using organoids as building blocks for implant formation or as an in vitro three-dimensional model will be highlighted. Full article
(This article belongs to the Special Issue Organoids Mimicking Articular Tissue)
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