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Optics
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Advances in Biophotonics Using Optical Microscopy Techniques
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Advances in Biophotonics Using Optical Microscopy Techniques

A special issue of Optics (ISSN 2673-3269). This special issue belongs to the section "Biomedical Optics".

Deadline for manuscript submissions: 20 October 2024 | Viewed by 6421

Special Issue Editor

Dr. Ellas Spyratou

E-Mail Website
Guest Editor
1. Physics Department, School of Applied Mathematical and Physical Sciences, National Technical University of Athens, Zografou Campus, 15780 Zografou, Greece
2. 2nd Department of Radiology, Medical School, National and Kapodistrian University of Athens, 15772 Athens, Greece
3. Department of Medicine, Democritus University of Thrace, 68100 Alexandroupolis, Greece
Interests: biophotonics; laser ablation; optical tweezers; nanoparticles; ionizing radiation; atomic force microscopy

Special Issue Information

Dear Colleagues,

Biophotonics is an emerging multidisciplinary research area encompassing all light-based technologies applied to the life sciences and medicine. Biophotonics uses monochromatic laser or laser-like non-ionizing radiation for diagnostic, imaging applications (in vivo and in vitro, at the cellular or molecular level) and therapy or surgery (e.g., biostimulation, tissue removal surgery, photodynamic therapy, cell micromanipulation). Today, modern optical microscopy techniques and instrumentations have driven to a new era of applied biophotonics interventions in biology, medicine, and nanotechnology. Advanced photon-based techniques are highlighted as very promising tools for the understanding of interaction mechanisms in molecular and cellular biology. The miniaturization of biophotonics tools had led to the research and development of novel strategies for prevention, diagnosis, and treatment of diseases at the nanoscale, at the sub-cellular and molecular level.

This Special Issue on “Advances in Biophotonics Using Optical Microscopy Techniques” will be a collection of original articles, short communications, and reviews focusing on recent progress in biophotonics in the field of optical tweezers, fluorescence microscopy, optical spectroscopy, hyperspectral enhanced dark-field microscopy, flow cytometry, optoelectronics, nanotechnology, laser nano-surgery, biosensing, and biochips. The issue is also open to optical microscopy techniques enabling real-time and/or in situ imaging or manipulation of living cells and tissue at high resolution and high contrast.

Dr. Ellas Spyratou
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Optics is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biophotonics
  • optical microscopy
  • optical tweezers
  • optoelectronics
  • biosensing
  • biochips
  • laser nano-surgery

Published Papers (3 papers)

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Research

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11 pages, 4027 KiB  
Article
Advantages of a Photodiode Detector Endoscopy System in Fluorescence-Guided Percutaneous Liver Biopsies
by Asier Marcos-Vidal, Pedram Heidari, Sheng Xu, Bradford J. Wood and Umar Mahmood
Optics 2023, 4(2), 340-350; https://doi.org/10.3390/opt4020025 - 15 May 2023
Viewed by 1076
Abstract
Image-guided liver biopsies can improve their success rate when combined with the optical detection of Indocyanine Green (ICG) fluorescence accumulated in tumors. Previous works used a camera coupled to a thin borescope to capture and quantify images from fluorescence emission during procedures; however, [...] Read more.
Image-guided liver biopsies can improve their success rate when combined with the optical detection of Indocyanine Green (ICG) fluorescence accumulated in tumors. Previous works used a camera coupled to a thin borescope to capture and quantify images from fluorescence emission during procedures; however, light-scattering prevented the formation of sharp images, and the time response for weakly fluorescent tumors was very low. Instead, replacing the camera with a photodiode detector shows an improved temporal resolution in a more compact and lighter device. This work presents the new design in a comparative study between both detection technologies, including an assessment of the temporal response and sensitivity to the presence of background fluorescence. Full article
(This article belongs to the Special Issue Advances in Biophotonics Using Optical Microscopy Techniques)
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11 pages, 2803 KiB  
Article
Advanced Raman Spectroscopy Based on Transfer Learning by Using a Convolutional Neural Network for Personalized Colorectal Cancer Diagnosis
by Dimitris Kalatzis, Ellas Spyratou, Maria Karnachoriti, Maria Anthi Kouri, Spyros Orfanoudakis, Nektarios Koufopoulos, Abraham Pouliakis, Nikolaos Danias, Ioannis Seimenis, Athanassios G. Kontos and Efstathios P. Efstathopoulos
Optics 2023, 4(2), 310-320; https://doi.org/10.3390/opt4020022 - 27 Apr 2023
Cited by 6 | Viewed by 1574
Abstract
Advanced Raman spectroscopy (RS) systems have gained new interest in the field of medicine as an emerging tool for in vivo tissue discrimination. The coupling of RS with artificial intelligence (AI) algorithms has given a boost to RS to analyze spectral data in [...] Read more.
Advanced Raman spectroscopy (RS) systems have gained new interest in the field of medicine as an emerging tool for in vivo tissue discrimination. The coupling of RS with artificial intelligence (AI) algorithms has given a boost to RS to analyze spectral data in real time with high specificity and sensitivity. However, limitations are still encountered due to the large amount of clinical data which are required for the pre-training process of AI algorithms. In this study, human healthy and cancerous colon specimens were surgically resected from different sites of the ascending colon and analyzed by RS. Two transfer learning models, the one-dimensional convolutional neural network (1D-CNN) and the 1D–ResNet transfer learning (1D-ResNet) network, were developed and evaluated using a Raman open database for the pre-training process which consisted of spectra of pathogen bacteria. According to the results, both models achieved high accuracy of 88% for healthy/cancerous tissue discrimination by overcoming the limitation of the collection of a large number of spectra for the pre-training process. This gives a boost to RS as an adjuvant tool for real-time biopsy and surgery guidance. Full article
(This article belongs to the Special Issue Advances in Biophotonics Using Optical Microscopy Techniques)
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Review

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26 pages, 4059 KiB  
Review
Gold Nanoparticles as Contrast Agents in Ophthalmic Imaging
by Alexandra Kavalaraki, Ellas Spyratou, Maria Anthi Kouri and Efstathios P. Efstathopoulos
Optics 2023, 4(1), 74-99; https://doi.org/10.3390/opt4010007 - 18 Jan 2023
Cited by 6 | Viewed by 2434
Abstract
Over the past few years, tremendous research concerning the possibilities of gold nanoparticles in medicine has been conducted. Gold nanoparticles (AuNPs) are considered to be unique nanostructures due to their extraordinary chemical and physical properties. This review article aims to bring into light [...] Read more.
Over the past few years, tremendous research concerning the possibilities of gold nanoparticles in medicine has been conducted. Gold nanoparticles (AuNPs) are considered to be unique nanostructures due to their extraordinary chemical and physical properties. This review article aims to bring into light the potential applications of gold nanoparticles for diagnostic purposes in ophthalmology. More specifically, attention will be drawn to the utilization of AuNPs as contrast agents (CAs) in optical coherence tomography (OCT) and photoacoustic imaging (PAI), which are two novel imaging modalities for the visualization of the eye. None of these techniques requires the use of an imaging adjuvant to function; however, the addition of a contrast agent has been proposed for image improvement, and AuNPs are attractive candidates for this purpose. The in vitro, ex vivo, and in vivo studies investigating and supporting this concept will be presented thoroughly to elucidate whether AuNPs are eligible for imaging enhancement owing to their optical characteristics. Full article
(This article belongs to the Special Issue Advances in Biophotonics Using Optical Microscopy Techniques)
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