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Obesities
Special Issues
Novel Therapeutic Strategies for Obesity and Cardiometabolic Diseases
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Special Issue "Novel Therapeutic Strategies for Obesity and Cardiometabolic Diseases"

A special issue of Obesities (ISSN 2673-4168). This special issue belongs to the section "Novel Therapeutic Strategies".

Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 4080

Special Issue Editor

Dr. Bruno Guigas

E-Mail Website1 Website2
Guest Editor
Leiden University Medical Center-LUMC, Leiden, The Netherlands
Interests: type 2 diabetes; immunometabolism; macrophages

Special Issue Information

Dear Colleagues,

The dramatic worldwide rise in obesity and related cardiometabolic diseases, such as type 2 diabetes, atherosclerosis, and chronic renal failure, is reaching epidemic proportions and poses a serious global threat to human health. While different types of lifestyle interventions and various drug treatments are currently available, new discoveries are still needed to better understand the pathophysiology of the cardiometabolic diseases and expand the therapeutic arsenal and/or strategies for improving patient’s health.

In the framework of this Special Issue, submission of both original research manuscripts and review articles will be encouraged on any relevant subjects linked to the development of novel therapeutic strategies for obesity and cardiometabolic diseases.

Dr. Bruno Guigas
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Obesities is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • obesity
  • insulin resistance
  • metaflammation
  • NASH
  • type 2 diabetes
  • cardiovascular diseases
  • drug targets
  • innovative therapies
  • lifestyle intervention

Published Papers (1 paper)

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Research

16 pages, 1570 KiB  
Article
Acute and Chronic Effects of Low-Volume High-Intensity Interval Training Compared to Moderate-Intensity Continuous Training on Glycemic Control and Body Composition in Older Women with Type 2 Diabetes
by
Alexis Marcotte-Chénard
,
Dominic Tremblay
,
Marie-Michelle Mony
,
Pierre Boulay
,
Martin Brochu
,
José A. Morais
,
Isabelle J. Dionne
,
Marie-France Langlois
,
Warner M. Mampuya
,
Daniel M. Tessier
,
Normand G. Boulé
and
Eléonor Riesco
Obesities 2021, 1(2), 72-87; https://doi.org/10.3390/Obesities1020007 - 22 Jun 2021
Cited by 3 | Viewed by 3418
Abstract
Objective: To compare the acute and chronic effects of low-volume high-intensity interval training (HIIT) to moderate-intensity continuous training (MICT) on glycemic control, body composition and continuous glucose monitoring (CGM) in older women with type 2 diabetes (T2D). Methods: Thirty older women (68 ± [...] Read more.
Objective: To compare the acute and chronic effects of low-volume high-intensity interval training (HIIT) to moderate-intensity continuous training (MICT) on glycemic control, body composition and continuous glucose monitoring (CGM) in older women with type 2 diabetes (T2D). Methods: Thirty older women (68 ± 5 years) with T2D were randomized in two groups—HIIT (75 min/week) or MICT (150 min/week). Glucose homeostasis (A1c, glucose, insulin, HOMA-IR2) and body composition (iDXA) were measured before and after the 12-week exercise intervention. During the first and last week of training (24-h before and 48-h after exercise), the following CGM-derived data were measured: 24-h and peak glucose levels, glucose variability and time spent in hypoglycemia as well as severe and mild hyperglycemia. Results: While lean body mass increased (p = 0.035), total and trunk fat mass decreased (p ≤ 0.007), without any difference between groups (p ≥ 0.81). Fasting glucose levels (p = 0.001) and A1c (p = 0.014) significantly improved in MICT only, with a significant difference between groups for fasting glucose (p = 0.02). Neither HIIT nor MICT impacted CGM-derived data at week 1 (p ≥ 0.25). However, 24-h and peak glucose levels, as well as time spent in mild hyperglycemia, decreased in HIIT at week 12 (p ≤ 0.03). Conclusion: These results suggest that 12 weeks of low-volume HIIT is enough to provide similar benefit to MICT for body composition and improve the acute effect of exercise when measured with CGM. Full article
(This article belongs to the Special Issue Novel Therapeutic Strategies for Obesity and Cardiometabolic Diseases)
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