Topical Collection "Diet and Multi-Omics"
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Editors
1. Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK
2. Department of Twin Research & Genetic Epidemiology, South Wing St Thomas’, King’s College London, London SE1 7EH, UK
Interests: personalized nutrition; metabolomics; microbiome; nutritional epidemiology; mendelian randomization; non-communicable diseases
Dr. Richard Webb
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Website
Co-Collection Editor
School of Health Sciences, Liverpool Hope University, Liverpool L16 9JD, UK
Interests: cardiometabolic; lipoproteins; lipids; nutrition; atherosclerosis
Topical Collection Information
Dear Colleagues,
With the recent shift in focus from food quantity to quality, consumers’ concerns and choices regarding healthy food have become a matter of prime importance. This has given rise to the concepts of ’personalized’ and ‘precision’ nutrition. Additionally, our understanding of the complex interplay between diet, health and disease as determined using so-called ‘omics’ technologies is growing. This is particularly timely as individuals now often look towards these personalized and precision nutrition approaches for guidance on healthier food choices. Moreover, recent advancements in omics tools and techniques have greatly extended the scope of their application within the nutrition sciences. As a result, a better understanding of the underlying interactions between diet and human physiology can be gained, whilst addressing the key challenges critical for the successful implementation of this science.
Dr. Mohsen Mazidi
Dr. Richard Webb
Collection Editors
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Keywords
- diet
- nutrients
- microbiome
- metabolites
- proteomics
- genomics
- omics
Published Papers (1 paper)
2023
Open AccessArticle
Investigating the Role of Ferroptosis-Related Genes in Ovarian Aging and the Potential for Nutritional Intervention
Viewed by 264
Abstract
With advancing age, women experience irreversible deterioration in the quality of their oocytes, resulting in reduced fertility. To gain a deeper understanding of the influence of ferroptosis-related genes on ovarian aging, we employed a comprehensive approach encompassing spatial transcriptomics, single-cell RNA sequencing, human
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With advancing age, women experience irreversible deterioration in the quality of their oocytes, resulting in reduced fertility. To gain a deeper understanding of the influence of ferroptosis-related genes on ovarian aging, we employed a comprehensive approach encompassing spatial transcriptomics, single-cell RNA sequencing, human ovarian pathology, and clinical biopsy. This investigation revealed the intricate interactions between ferroptosis and cellular energy metabolism in aging germ cells, shedding light on the underlying mechanisms. Our study involved 75 patients with ovarian senescence insufficiency, and we utilized multi-histological predictions of ferroptosis-related genes. Following a two-month supplementation period with DHEA, Ubiquinol CoQ10, and Cleo-20 T3, we examined the changes in hub genes. Our results showed that TFRC, NCOA4, and SLC3A2 were significantly reduced and GPX4 was increased in the supplement group, confirming our prediction based on multi-omic analysis. Our hypothesis is that supplementation would enhance the mitochondrial tricarboxylic acid cycle (TCA) or electron transport chain (ETC), resulting in increased levels of the antioxidant enzyme GPX4, reduced lipid peroxide accumulation, and reduced ferroptosis. Overall, our results suggest that supplementation interventions have a notable positive impact on in vitro fertilization (IVF) outcomes in aging cells by improving metal ion and energy metabolism, thereby enhancing oocyte quality in older women.
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