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The Effect of Dietary Bioactive Compounds on Cancer Prevention

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Phytochemicals and Human Health".

Deadline for manuscript submissions: closed (25 January 2024) | Viewed by 8167

Special Issue Editors

State Key Laboratory for Quality Research in Chinese Medicines, Macau University of Science and Technology, Macao 999078, China
Interests: mass spectrometry based multiomics, including foodomics
School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China
Interests: hepatocellular carcinoma; pancreatic cancer; drug resistance; tumour microenvironment; immunotherapy
Special Issues, Collections and Topics in MDPI journals
Singapore Institute of Food and Biotechnology Innovation (SIFBI), Agency for Science Technology and Research (A*STAR), 30 Medical Drive, Singapore 117609, Singapore
Interests: probiotics; gut microbiota; phytochemicals; bioactivities; analytical chemistry
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Cancer is a leading cause of death worldwide, accounting for nearly 10 million deaths or nearly one in six deaths in 2020. The cancer burden continues to grow globally, exerting tremendous physical, emotional and financial strain on individuals, families, communities and health systems. Though the diagnostic and prognostic approaches of cancer showed great improvement, effective preventive methods remain lacking. Moreover, the treatment via surgery, chemotherapy, or radiotherapy was expensive and had high recurrence rate. Thus, it is urgent to develop a safe, effective, and inexpensive anticancer therapeutic or preventive method. Dietary bioactive compounds are nutritional constituents that widely exist in foods. It was reported that they could effectively inhibit the development of cancer, and could induce the apoptosis of cancer cells. Additionally, it is still a common knowledge that some foods are benefit for human health. Most researchers focused on the food components to try to state the mechanism of foods on human health, as well as their relationships. As we know, the bioactive compounds, such as polysaccharides, flavonoids, phenolic acids, ginsenosides, vitamin, terpenoids, amino acids, and carboxylic acids, widely exist in many foods, e.g. tea,  herbs, fruits, fish, vegetables. Most importantly, development of medicinal foods, which are beneficial for human health, has become the most popular topic in recent years. Thus, the current issue will be focused on the mechanism and the effect of dietary bioactive compounds on cancer prevention.

Dr. Jianlin Wu
Dr. Ning Wang
Dr. Ren-You Gan
Guest Editor

Manuscript Submission Information

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Keywords

  • dietary bioactive compounds
  • polysaccharides
  • ginsenosides
  • phenolic acids
  • flavonoids
  • carboxylic acids
  • colorectal cancer
  • liver cancer
  • inflammation
  • cancer prevention
  • cancer therapy

Published Papers (4 papers)

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Research

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16 pages, 4517 KiB  
Article
Sulforaphane Inhibits Adhesion and Migration of Cisplatin- and Gemcitabine-Resistant Bladder Cancer Cells In Vitro
by Hui Xie, Jochen Rutz, Sebastian Maxeiner, Timothy Grein, Anita Thomas, Eva Juengel, Felix K.-H. Chun, Jindrich Cinatl, Axel Haferkamp, Igor Tsaur and Roman A. Blaheta
Nutrients 2024, 16(5), 623; https://doi.org/10.3390/nu16050623 - 23 Feb 2024
Viewed by 516
Abstract
Only 20% of patients with muscle-invasive bladder carcinoma respond to cisplatin-based chemotherapy. Since the natural phytochemical sulforaphane (SFN) exhibits antitumor properties, its influence on the adhesive and migratory properties of cisplatin- and gemcitabine-sensitive and cisplatin- and gemcitabine-resistant RT4, RT112, T24, and TCCSUP bladder [...] Read more.
Only 20% of patients with muscle-invasive bladder carcinoma respond to cisplatin-based chemotherapy. Since the natural phytochemical sulforaphane (SFN) exhibits antitumor properties, its influence on the adhesive and migratory properties of cisplatin- and gemcitabine-sensitive and cisplatin- and gemcitabine-resistant RT4, RT112, T24, and TCCSUP bladder cancer cells was evaluated. Mechanisms behind the SFN influence were explored by assessing levels of the integrin adhesion receptors β1 (total and activated) and β4 and their functional relevance. To evaluate cell differentiation processes, E- and N-cadherin, vimentin and cytokeratin (CK) 8/18 expression were examined. SFN down-regulated bladder cancer cell adhesion with cell line and resistance-specific differences. Different responses to SFN were reflected in integrin expression that depended on the cell line and presence of resistance. Chemotactic movement of RT112, T24, and TCCSUP (RT4 did not migrate) was markedly blocked by SFN in both chemo-sensitive and chemo-resistant cells. Integrin-blocking studies indicated β1 and β4 as chemotaxis regulators. N-cadherin was diminished by SFN, particularly in sensitive and resistant T24 and RT112 cells, whereas E-cadherin was increased in RT112 cells (not detectable in RT4 and TCCSup cells). Alterations in vimentin and CK8/18 were also apparent, though not the same in all cell lines. SFN exposure resulted in translocation of E-cadherin (RT112), N-cadherin (RT112, T24), and vimentin (T24). SFN down-regulated adhesion and migration in chemo-sensitive and chemo-resistant bladder cancer cells by acting on integrin β1 and β4 expression and inducing the mesenchymal–epithelial translocation of cadherins and vimentin. SFN does, therefore, possess potential to improve bladder cancer therapy. Full article
(This article belongs to the Special Issue The Effect of Dietary Bioactive Compounds on Cancer Prevention)
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Review

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19 pages, 1792 KiB  
Review
Possible Mechanisms of Dark Tea in Cancer Prevention and Management: A Comprehensive Review
by Huilin Deng, Jia Liu, Ying Xiao, Jian-Lin Wu and Rui Jiao
Nutrients 2023, 15(18), 3903; https://doi.org/10.3390/nu15183903 - 07 Sep 2023
Cited by 1 | Viewed by 2545
Abstract
Tea is one of the most popular drinks in the world. Dark tea is a kind of post-fermented tea with unique sensory characteristics that is produced by the special fermentation of microorganisms. It contains many bioactive substances, such as tea polyphenols, theabrownin, tea [...] Read more.
Tea is one of the most popular drinks in the world. Dark tea is a kind of post-fermented tea with unique sensory characteristics that is produced by the special fermentation of microorganisms. It contains many bioactive substances, such as tea polyphenols, theabrownin, tea polysaccharides, etc., which have been reported to be beneficial to human health. This paper reviewed the latest research on dark tea’s potential in preventing and managing cancer, and the mechanisms mainly involved anti-oxidation, anti-inflammation, inhibiting cancer cell proliferation, inducing cancer cell apoptosis, inhibiting tumor metastasis, and regulating intestinal flora. The purpose of this review is to accumulate evidence on the anti-cancer effects of dark tea, the corresponding mechanisms and limitations of dark tea for cancer prevention and management, the future prospects, and demanding questions about dark tea’s possible contributions as an anti-cancer adjuvant. Full article
(This article belongs to the Special Issue The Effect of Dietary Bioactive Compounds on Cancer Prevention)
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16 pages, 831 KiB  
Review
Dietary Plant Polysaccharides for Cancer Prevention: Role of Immune Cells and Gut Microbiota, Challenges and Perspectives
by Anqi Wang, Ying Liu, Shan Zeng, Yuanyuan Liu, Wei Li, Dingtao Wu, Xu Wu, Liang Zou and Huijuan Chen
Nutrients 2023, 15(13), 3019; https://doi.org/10.3390/nu15133019 - 03 Jul 2023
Cited by 3 | Viewed by 1843
Abstract
Dietary plant polysaccharides, one of the main sources of natural polysaccharides, possess significant cancer prevention activity and potential development value in the food and medicine fields. The anti-tumor mechanisms of plant polysaccharides are mainly elaborated from three perspectives: enhancing immunoregulation, inhibiting tumor cell [...] Read more.
Dietary plant polysaccharides, one of the main sources of natural polysaccharides, possess significant cancer prevention activity and potential development value in the food and medicine fields. The anti-tumor mechanisms of plant polysaccharides are mainly elaborated from three perspectives: enhancing immunoregulation, inhibiting tumor cell growth and inhibiting tumor cell invasion and metastasis. The immune system plays a key role in cancer progression, and immunomodulation is considered a significant pathway for cancer prevention or treatment. Although much progress has been made in revealing the relationship between the cancer prevention activity of polysaccharides and immunoregulation, huge challenges are still met in the research and development of polysaccharides. Results suggest that certain polysaccharide types and glycosidic linkage forms significantly affect the biological activity of polysaccharides in immunoregulation. At present, the in vitro anti-tumor effects and immunoregulation of dietary polysaccharides are widely reported in articles; however, the anti-tumor effects and in vivo immunoregulation of dietary polysaccharides are still deserving of further investigation. In this paper, aspects of the mechanisms behind dietary polysaccharides’ cancer prevention activity achieved through immunoregulation, the role of immune cells in cancer progression, the role of the mediatory relationship between the gut microbiota and dietary polysaccharides in immunoregulation and cancer prevention are systematically summarized, with the aim of encouraging future research on the use of dietary polysaccharides for cancer prevention. Full article
(This article belongs to the Special Issue The Effect of Dietary Bioactive Compounds on Cancer Prevention)
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24 pages, 1352 KiB  
Review
Targeting Wnt/β-Catenin Pathway by Flavonoids: Implication for Cancer Therapeutics
by Pratibha Pandey, Fahad Khan, Sara A. Seifeldin, Khalid Alshaghdali, Samra Siddiqui, Mohamed Elfatih Abdelwadoud, Manish Vyas, Mohd Saeed, Avijit Mazumder and Amir Saeed
Nutrients 2023, 15(9), 2088; https://doi.org/10.3390/nu15092088 - 26 Apr 2023
Cited by 4 | Viewed by 2498
Abstract
The Wnt pathway has been recognized for its crucial role in human development and homeostasis, but its dysregulation has also been linked to several disorders, including cancer. Wnt signaling is crucial for the development and metastasis of several kinds of cancer. Moreover, members [...] Read more.
The Wnt pathway has been recognized for its crucial role in human development and homeostasis, but its dysregulation has also been linked to several disorders, including cancer. Wnt signaling is crucial for the development and metastasis of several kinds of cancer. Moreover, members of the Wnt pathway have been proven to be effective biomarkers and promising cancer therapeutic targets. Abnormal stimulation of the Wnt signaling pathway has been linked to the initiation and advancement of cancer in both clinical research and in vitro investigations. A reduction in cancer incidence rate and an improvement in survival may result from targeting the Wnt/β-catenin pathway. As a result, blocking this pathway has been the focus of cancer research, and several candidates that can be targeted are currently being developed. Flavonoids derived from plants exhibit growth inhibitory, apoptotic, anti-angiogenic, and anti-migratory effects against various malignancies. Moreover, flavonoids influence different signaling pathways, including Wnt, to exert their anticancer effects. In this review, we comprehensively evaluate the influence of flavonoids on cancer development and metastasis by focusing on the Wnt/β-catenin signaling pathway, and we provide evidence of their impact on a number of molecular targets. Overall, this review will enhance our understanding of these natural products as Wnt pathway modulators. Full article
(This article belongs to the Special Issue The Effect of Dietary Bioactive Compounds on Cancer Prevention)
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