Special Issue "The Effect of Dietary Bioactive Compounds on Cancer Prevention"

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Phytochemicals and Human Health".

Deadline for manuscript submissions: 25 January 2024 | Viewed by 5470

Special Issue Editors

State Key Laboratory for Quality Research in Chinese Medicines, Macau University of Science and Technology, Macao 999078, China
Interests: mass spectrometry based multiomics, including foodomics
School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China
Interests: hepatocellular carcinoma; pancreatic cancer; drug resistance; tumour microenvironment; immunotherapy
Special Issues, Collections and Topics in MDPI journals
Singapore Institute of Food and Biotechnology Innovation (SIFBI), Agency for Science Technology and Research (A*STAR), 30 Medical Drive, Singapore 117609, Singapore
Interests: probiotics; gut microbiota; phytochemicals; bioactivities; analytical chemistry
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Cancer is a leading cause of death worldwide, accounting for nearly 10 million deaths or nearly one in six deaths in 2020. The cancer burden continues to grow globally, exerting tremendous physical, emotional and financial strain on individuals, families, communities and health systems. Though the diagnostic and prognostic approaches of cancer showed great improvement, effective preventive methods remain lacking. Moreover, the treatment via surgery, chemotherapy, or radiotherapy was expensive and had high recurrence rate. Thus, it is urgent to develop a safe, effective, and inexpensive anticancer therapeutic or preventive method. Dietary bioactive compounds are nutritional constituents that widely exist in foods. It was reported that they could effectively inhibit the development of cancer, and could induce the apoptosis of cancer cells. Additionally, it is still a common knowledge that some foods are benefit for human health. Most researchers focused on the food components to try to state the mechanism of foods on human health, as well as their relationships. As we know, the bioactive compounds, such as polysaccharides, flavonoids, phenolic acids, ginsenosides, vitamin, terpenoids, amino acids, and carboxylic acids, widely exist in many foods, e.g. tea,  herbs, fruits, fish, vegetables. Most importantly, development of medicinal foods, which are beneficial for human health, has become the most popular topic in recent years. Thus, the current issue will be focused on the mechanism and the effect of dietary bioactive compounds on cancer prevention.

Dr. Jianlin Wu
Dr. Ning Wang
Dr. Ren-You Gan
Guest Editor

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Keywords

  • dietary bioactive compounds
  • polysaccharides
  • ginsenosides
  • phenolic acids
  • flavonoids
  • carboxylic acids
  • colorectal cancer
  • liver cancer
  • inflammation
  • cancer prevention
  • cancer therapy

Published Papers (3 papers)

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Review

19 pages, 1792 KiB  
Review
Possible Mechanisms of Dark Tea in Cancer Prevention and Management: A Comprehensive Review
Nutrients 2023, 15(18), 3903; https://doi.org/10.3390/nu15183903 - 07 Sep 2023
Viewed by 1724
Abstract
Tea is one of the most popular drinks in the world. Dark tea is a kind of post-fermented tea with unique sensory characteristics that is produced by the special fermentation of microorganisms. It contains many bioactive substances, such as tea polyphenols, theabrownin, tea [...] Read more.
Tea is one of the most popular drinks in the world. Dark tea is a kind of post-fermented tea with unique sensory characteristics that is produced by the special fermentation of microorganisms. It contains many bioactive substances, such as tea polyphenols, theabrownin, tea polysaccharides, etc., which have been reported to be beneficial to human health. This paper reviewed the latest research on dark tea’s potential in preventing and managing cancer, and the mechanisms mainly involved anti-oxidation, anti-inflammation, inhibiting cancer cell proliferation, inducing cancer cell apoptosis, inhibiting tumor metastasis, and regulating intestinal flora. The purpose of this review is to accumulate evidence on the anti-cancer effects of dark tea, the corresponding mechanisms and limitations of dark tea for cancer prevention and management, the future prospects, and demanding questions about dark tea’s possible contributions as an anti-cancer adjuvant. Full article
(This article belongs to the Special Issue The Effect of Dietary Bioactive Compounds on Cancer Prevention)
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16 pages, 831 KiB  
Review
Dietary Plant Polysaccharides for Cancer Prevention: Role of Immune Cells and Gut Microbiota, Challenges and Perspectives
Nutrients 2023, 15(13), 3019; https://doi.org/10.3390/nu15133019 - 03 Jul 2023
Viewed by 1315
Abstract
Dietary plant polysaccharides, one of the main sources of natural polysaccharides, possess significant cancer prevention activity and potential development value in the food and medicine fields. The anti-tumor mechanisms of plant polysaccharides are mainly elaborated from three perspectives: enhancing immunoregulation, inhibiting tumor cell [...] Read more.
Dietary plant polysaccharides, one of the main sources of natural polysaccharides, possess significant cancer prevention activity and potential development value in the food and medicine fields. The anti-tumor mechanisms of plant polysaccharides are mainly elaborated from three perspectives: enhancing immunoregulation, inhibiting tumor cell growth and inhibiting tumor cell invasion and metastasis. The immune system plays a key role in cancer progression, and immunomodulation is considered a significant pathway for cancer prevention or treatment. Although much progress has been made in revealing the relationship between the cancer prevention activity of polysaccharides and immunoregulation, huge challenges are still met in the research and development of polysaccharides. Results suggest that certain polysaccharide types and glycosidic linkage forms significantly affect the biological activity of polysaccharides in immunoregulation. At present, the in vitro anti-tumor effects and immunoregulation of dietary polysaccharides are widely reported in articles; however, the anti-tumor effects and in vivo immunoregulation of dietary polysaccharides are still deserving of further investigation. In this paper, aspects of the mechanisms behind dietary polysaccharides’ cancer prevention activity achieved through immunoregulation, the role of immune cells in cancer progression, the role of the mediatory relationship between the gut microbiota and dietary polysaccharides in immunoregulation and cancer prevention are systematically summarized, with the aim of encouraging future research on the use of dietary polysaccharides for cancer prevention. Full article
(This article belongs to the Special Issue The Effect of Dietary Bioactive Compounds on Cancer Prevention)
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24 pages, 1352 KiB  
Review
Targeting Wnt/β-Catenin Pathway by Flavonoids: Implication for Cancer Therapeutics
Nutrients 2023, 15(9), 2088; https://doi.org/10.3390/nu15092088 - 26 Apr 2023
Cited by 2 | Viewed by 1890
Abstract
The Wnt pathway has been recognized for its crucial role in human development and homeostasis, but its dysregulation has also been linked to several disorders, including cancer. Wnt signaling is crucial for the development and metastasis of several kinds of cancer. Moreover, members [...] Read more.
The Wnt pathway has been recognized for its crucial role in human development and homeostasis, but its dysregulation has also been linked to several disorders, including cancer. Wnt signaling is crucial for the development and metastasis of several kinds of cancer. Moreover, members of the Wnt pathway have been proven to be effective biomarkers and promising cancer therapeutic targets. Abnormal stimulation of the Wnt signaling pathway has been linked to the initiation and advancement of cancer in both clinical research and in vitro investigations. A reduction in cancer incidence rate and an improvement in survival may result from targeting the Wnt/β-catenin pathway. As a result, blocking this pathway has been the focus of cancer research, and several candidates that can be targeted are currently being developed. Flavonoids derived from plants exhibit growth inhibitory, apoptotic, anti-angiogenic, and anti-migratory effects against various malignancies. Moreover, flavonoids influence different signaling pathways, including Wnt, to exert their anticancer effects. In this review, we comprehensively evaluate the influence of flavonoids on cancer development and metastasis by focusing on the Wnt/β-catenin signaling pathway, and we provide evidence of their impact on a number of molecular targets. Overall, this review will enhance our understanding of these natural products as Wnt pathway modulators. Full article
(This article belongs to the Special Issue The Effect of Dietary Bioactive Compounds on Cancer Prevention)
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