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Nutrients
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Marine Nutraceuticals and Human Health
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Marine Nutraceuticals and Human Health

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Public Health".

Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 10268

Special Issue Editors

Dr. Paola Nieri

E-Mail Website
Guest Editor
Department of Pharmacy, University of Pisa, 56126 Pisa, Italy
Interests: natural compounds; microRNAs; anticancer; marine compounds; mediterranean diet; anti-inflammatory compounds; nutrigenomics
Special Issues, Collections and Topics in MDPI journals
Dr. Valerio Zupo

E-Mail Website
Guest Editor
Department of Ecosustainable Marine Biotechnology, Stazione Zoologica Anton Dohrn, Naples, Italy
Interests: chemical ecology; drug discovery; biotechnology; marine invertebrates; microalgae; diatoms; sexual biology; invertebrate physiology; ecological modelling; aquaculture
Special Issues, Collections and Topics in MDPI journals
Dr. Maria Costantini

E-Mail Website
Guest Editor
Department of Marine Biotechnology, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Napoli, Italy
Interests: genomic/transcriptomic; marine biotechnology; metabolites in microalgae; nutraceuticals in fish; acquaculture
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Seas represent a huge source of biodiversity that can sustainably provide natural compounds useful for human health. Many types of marine chemicals (polyphenols, carotenoids, polysaccharides, PUFAs, sterols, and others) with relevance for human wellbeing have already been discovered. New foods derived from the sea or from aquaculture are an excellent opportunity to provide new functional foods and food supplements for industry. This is particularly interesting when we consider the urgent need for alternative food sources, since future increases in the world population, particularly those over sixty, will need appropriate care for preventing and combating chronic diseases.

In this context, although many marine natural products have been already characterized, many more are yet to be discovered, because the huge biodiversity of marine ecosystems is still largely unexplored.

The present Special Issue aims at collecting contributions describing new functional compounds with possible effects on human health obtained from marine organisms. Further, contributions investigating the mechanisms of action or the pharmacokinetics of known marine molecules are welcome. Clinical studies on the beneficial effects of marine molecules in the prevention or treatment of diseases are also encouraged. Both original studies and up-to date reviews are welcome.

Prof. Dr. Paola Nieri
Dr. Valerio Zupo
Dr. Maria Costantini
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Marine
  • Seafood
  • Macroalga or seaweed
  • Microalga
  • Sponge
  • Shellfish
  • Jellyfish
  • Shrimp
  • Octopus
  • Fish
  • Sea urchin

Published Papers (4 papers)

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Research

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15 pages, 1759 KiB  
Article
In Vitro Anti-Inflammatory and Vasculoprotective Effects of Red Cell Extract from the Black Sea Urchin Arbacia lixula
by Stefano Quarta, Egeria Scoditti, Vincenzo Zonno, Luisa Siculella, Fabrizio Damiano, Maria Annunziata Carluccio and Patrizia Pagliara
Nutrients 2023, 15(7), 1672; https://doi.org/10.3390/nu15071672 - 29 Mar 2023
Viewed by 1803
Abstract
Sea urchins have emerged as an important source of bioactive compounds with anti-inflammatory and antioxidant properties relevant to human health. Since inflammation is a crucial pathogenic process in the development and progression of atherosclerosis, we here assessed the potential anti-inflammatory and vasculoprotective effects [...] Read more.
Sea urchins have emerged as an important source of bioactive compounds with anti-inflammatory and antioxidant properties relevant to human health. Since inflammation is a crucial pathogenic process in the development and progression of atherosclerosis, we here assessed the potential anti-inflammatory and vasculoprotective effects of coelomic red-cell methanolic extract of the black sea urchin Arbacia lixula in an in vitro model of endothelial cell dysfunction. Human microvascular endothelial cells (HMEC-1) were pretreated with A. lixula red-cell extract (10 and 100 μg/mL) before exposure to the pro-inflammatory cytokine tumor necrosis factor (TNF)-α. The extract was non-toxic after 24 h cell treatment and was characterized by antioxidant power and phenol content. The TNF-α-stimulated expression of adhesion molecules (VCAM-1, ICAM-1) and cytokines/chemokines (MCP-1, CCL-5, IL-6, IL-8, M-CSF) was significantly attenuated by A. lixula red-cell extract. This was functionally accompanied by a reduction in monocyte adhesion and chemotaxis towards activated endothelial cells. At the molecular level, the tested extract significantly counteracted the TNF-α-stimulated activation of the pro-inflammatory transcription factor NF-κB. These results provide evidence of potential anti-atherosclerotic properties of A. lixula red-cell extract, and open avenues in the discovery and development of dietary supplements and/or drugs for the prevention or treatment of cardiovascular diseases. Full article
(This article belongs to the Special Issue Marine Nutraceuticals and Human Health)
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20 pages, 2033 KiB  
Article
Saponin and Fatty Acid Profiling of the Sea Cucumber Holothuria atra, α-Glucosidase Inhibitory Activity and the Identification of a Novel Triterpene Glycoside
by Yunita Eka Puspitasari, Emmy Tuenter, Kenn Foubert, Herawati Herawati, Anik Martinah Hariati, Aulanni’am Aulanni’am, Luc Pieters, Tess De Bruyne and Nina Hermans
Nutrients 2023, 15(4), 1033; https://doi.org/10.3390/nu15041033 - 19 Feb 2023
Cited by 2 | Viewed by 2353
Abstract
Saponin-rich sea cucumber extracts have shown antidiabetic effects in a few reports. Although the triterpene glycosides of sea cucumbers are commonly isolated from their Cuvierian tubules, these are absent in Holothuria atra Jaeger. Therefore, this study intended to investigate the saponin profile in [...] Read more.
Saponin-rich sea cucumber extracts have shown antidiabetic effects in a few reports. Although the triterpene glycosides of sea cucumbers are commonly isolated from their Cuvierian tubules, these are absent in Holothuria atra Jaeger. Therefore, this study intended to investigate the saponin profile in the body wall of H. atra, as well as to assess the α-glucosidase inhibitory activity of the H. atra extracts. The chemical profiling of sea cucumber extracts was conducted by UPLC-HRMS analysis. This resulted in the tentative identification of 11 compounds, 7 of which have not been reported in the H. Atra body wall before. Additionally, two triterpene glycosides were purified and their structures were elucidated based on HRMS and NMR data: desholothurin B (1), and a novel epimer, 12-epi-desholothurin B (2). Moreover, the fatty acid profile of the H. atra body wall was investigated by GC-MS. It was found that the Me90 fraction of the H. atra body wall showed the strongest α-glucosidase inhibitory activity (IC50 value 0.158 ± 0.002 mg/mL), thus making it more potent than acarbose (IC50 value 2.340 ± 0.044 mg/mL). Full article
(This article belongs to the Special Issue Marine Nutraceuticals and Human Health)
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10 pages, 1870 KiB  
Communication
Omega-3 PUFAs as a Dietary Supplement in Senile Systemic Amyloidosis
by Lidia Ciccone, Susanna Nencetti, Armando Rossello, Lucia Barlettani, Nicolò Tonali, Paola Nieri and Elisabetta Orlandini
Nutrients 2023, 15(3), 749; https://doi.org/10.3390/nu15030749 - 01 Feb 2023
Cited by 1 | Viewed by 1816
Abstract
Eicosapentaenoic acid (EPA; 20:5) and docosahexaenoic acid (DHA; 22:6), two omega-3 poly-unsaturated fatty acids (PUFAs), are the main components in oil derived from fish and other marine organisms. EPA and DHA are commercially available as dietary supplements and are considered to be very [...] Read more.
Eicosapentaenoic acid (EPA; 20:5) and docosahexaenoic acid (DHA; 22:6), two omega-3 poly-unsaturated fatty acids (PUFAs), are the main components in oil derived from fish and other marine organisms. EPA and DHA are commercially available as dietary supplements and are considered to be very safe and contribute to guaranteeing human health. Studies report that PUFAs have a role in contrasting neurodegenerative processes related to amyloidogenic proteins, such as β-amyloid for AD, α-synuclein in PD, and transthyretin (TTR) in TTR amyloidosis. In this context, we investigated if EPA and DHA can interact directly with TTR, binding inside the thyroxin-binding pockets (T4BP) that contribute to the tetramer stabilization. The data obtained showed that EPA and DHA can contribute to stabilizing the TTR tetramer through interactions with T4BP. Full article
(This article belongs to the Special Issue Marine Nutraceuticals and Human Health)
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Review

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23 pages, 1110 KiB  
Review
Bioactive Molecules from Marine Diatoms and Their Value for the Nutraceutical Industry
by Paola Nieri, Sara Carpi, Roberta Esposito, Maria Costantini and Valerio Zupo
Nutrients 2023, 15(2), 464; https://doi.org/10.3390/nu15020464 - 16 Jan 2023
Cited by 12 | Viewed by 3353
Abstract
The search for novel sources of nutrients is among the basic goals for achievement of sustainable progress. In this context, microalgae are relevant organisms, being rich in high-value compounds and able to grow in open ponds or photobioreactors, thus enabling profitable exploitation of [...] Read more.
The search for novel sources of nutrients is among the basic goals for achievement of sustainable progress. In this context, microalgae are relevant organisms, being rich in high-value compounds and able to grow in open ponds or photobioreactors, thus enabling profitable exploitation of aquatic resources. Microalgae, a huge taxon containing photosynthetic microorganisms living in freshwater, as well as in brackish and marine waters, typically unicellular and eukaryotic, include green algae (Chlorophyceae), red algae (Rhodophyceae), brown algae (Phaeophyceae) and diatoms (Bacillariophyceae). In recent decades, diatoms have been considered the most sustainable sources of nutrients for humans with respect to other microalgae. This review focuses on studies exploring their bio-pharmacological activities when relevant for human disease prevention and/or treatment. In addition, we considered diatoms and their extracts (or purified compounds) when relevant for specific nutraceutical applications. Full article
(This article belongs to the Special Issue Marine Nutraceuticals and Human Health)
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