nutrients-logo

Journal Browser

Journal Browser

Dietary Magnesium for Health and Diseases

A special issue of Nutrients (ISSN 2072-6643).

Deadline for manuscript submissions: closed (20 July 2019) | Viewed by 41514

Special Issue Editors

Department DI.PE.CA, Geriatric Unit, University Hospital AOUP, University of Palermo, 90127 Palermo, Italy
Interests: Mediterranean diet; aging; diabetes; hypertension; dementia; magnesium
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In this Special Issue, Prof. Mario Barbagallo and I would like to explore the importance of dietary magnesium (Mg) on healthy aging in some papers. It is widely known that older people suffer from a wide deficiency in Mg status. Among the most common causes, poor dietary intake is probably among the most important. Older people, in fact, introduce a very limited amount of foods rich in Mg, finally leading to poor Mg status.

Poor Mg intake seems to be associated with a spectrum of diseases common in older people such as diabetes; cardiovascular disease; dementia; and, finally, death. However, increasing research is supporting the concept that Mg could be implied in the pathogenesis of other diseases such as osteoarthritis and osteoporosis.

This Special Issue will therefore offer to the reader the state-of-the-art regarding this important topic in order to better understand the clinical importance of poor Mg intake in older people.

Dr. Nicola Veronese
Prof. Mario Barbagallo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • magnesium
  • older people
  • aging
  • cardiovascular disease
  • dementia
  • frailty

Published Papers (5 papers)

Order results
Result details
Select all
Export citation of selected articles as:

Research

10 pages, 249 KiB  
Article
Differences in Serum Magnesium Levels in Diabetic and Non-Diabetic Patients Following One-Anastomosis Gastric Bypass
by Eva Winzer, Igor Grabovac, Bernhard Ludvik, Renate Kruschitz, Karin Schindler, Gerhard Prager, Carmen Klammer, Lee Smith, Friedrich Hoppichler, Rodrig Marculescu and Maria Wakolbinger
Nutrients 2019, 11(9), 1984; https://doi.org/10.3390/nu11091984 - 22 Aug 2019
Cited by 5 | Viewed by 2667
Abstract
Patients with obesity and type 2 diabetes mellitus (T2DM) are regarded to have reduced serum magnesium (Mg) concentrations. We aimed to assess the changes in serum Mg concentrations at 12-month follow-up in patients, with and without T2DM, who underwent one anastomosis gastric bypass [...] Read more.
Patients with obesity and type 2 diabetes mellitus (T2DM) are regarded to have reduced serum magnesium (Mg) concentrations. We aimed to assess the changes in serum Mg concentrations at 12-month follow-up in patients, with and without T2DM, who underwent one anastomosis gastric bypass surgery. Overall, 50 patients (80% female, age 42.2 (12.5) years) with morbid obesity (mean baseline BMI 43.8 (4.3) kg/m2) were included in the analysis. Half of the included patients had T2DM diagnosed at baseline, and these patients showed lower serum Mg concentration (0.78 (0.07)) vs. 0.83 (0.05) mmol/L; p = 0.006), higher blood glucose levels (129.9 (41.3) vs. 87.6 (8.1) mg/dL; p < 0.001) as well as HbA1c concentrations (6.7 (1.4) vs. 5.3 (0.5)%; p < 0.001). During follow-up, BMI and glucose levels showed a decrease; however, serum Mg levels remained stable. At baseline 42% of patients were found to be Mg deficient, which was reduced to 33% at six months and to 30% at 12 months follow-up. Moreover, patients with T2DM had an odds ratio of 9.5 (95% CI = 3.0–29.7; p < 0.001) for magnesium deficiency when compared to patients without T2DM. Further research into the role of Mg and its role in T2DM and other obesity-related comorbidities are needed. Full article
(This article belongs to the Special Issue Dietary Magnesium for Health and Diseases)
12 pages, 641 KiB  
Article
Impact of Magnesium Supplementation in Muscle Damage of Professional Cyclists Competing in a Stage Race
by Alfredo Córdova, Juan Mielgo-Ayuso, Enrique Roche, Alberto Caballero-García and Diego Fernandez-Lázaro
Nutrients 2019, 11(8), 1927; https://doi.org/10.3390/nu11081927 - 16 Aug 2019
Cited by 12 | Viewed by 13427
Abstract
Magnesium is a cofactor of different enzymatic reactions involved in anabolic and catabolic processes that affect muscular performance during exercise. In addition, it has been suggested that magnesium could participate in maintaining muscle integrity during demanding effort. The main purpose of this study [...] Read more.
Magnesium is a cofactor of different enzymatic reactions involved in anabolic and catabolic processes that affect muscular performance during exercise. In addition, it has been suggested that magnesium could participate in maintaining muscle integrity during demanding effort. The main purpose of this study was to analyze the effects of magnesium supplementation in preventing muscle damage in professional cyclists taking part in a 21-day cycling stage race. Eighteen male professional cyclists (n = 18) from two teams were recruited to participate in the research. They were divided into 2 groups: the control group (n = 9) and the magnesium-supplemented group (n = 9). The supplementation consisted of an intake of 400 mg/day of magnesium during the 3 weeks of competition. Blood samples were collected according to World Anti-Doping Agency rules at three specific moments during competition: immediately before the race; mid competition; and before the last stage. Levels of serum and erythrocyte magnesium, lactate dehydrogenase, creatinine kinase, aspartate transaminase, alanine transaminase, myoglobin, aldolase, total proteins, cortisol and creatinine were determined. Serum and erythrocyte magnesium levels decreased during the race. Circulating tissue markers increased at the end of the race in both groups. However, myoglobin increase was mitigated in the supplemented group compared with the controls. We conclude that magnesium supplementation seems to exert a protective effect on muscle damage. Full article
(This article belongs to the Special Issue Dietary Magnesium for Health and Diseases)
Show Figures

Figure 1

17 pages, 1821 KiB  
Article
Predicting and Testing Bioavailability of Magnesium Supplements
by Laura Blancquaert, Chris Vervaet and Wim Derave
Nutrients 2019, 11(7), 1663; https://doi.org/10.3390/nu11071663 - 20 Jul 2019
Cited by 23 | Viewed by 16866
Abstract
Despite the presumption of the beneficial effects of magnesium supplementation, little is known about the pharmacokinetics of different magnesium formulations. We aimed to investigate the value of two in vitro approaches to predict bioavailability of magnesium and to validate this in subsequent in [...] Read more.
Despite the presumption of the beneficial effects of magnesium supplementation, little is known about the pharmacokinetics of different magnesium formulations. We aimed to investigate the value of two in vitro approaches to predict bioavailability of magnesium and to validate this in subsequent in vivo testing. In vitro assessment of 15 commercially available magnesium formulations was performed by means of a Simulator of the Human Intestinal Microbial Ecosystem (SHIME®) and by dissolution tests. Two magnesium formulations with contrasting bioavailability prediction from both in vitro tests (best vs. worst) were selected for in vivo testing in 30 subjects. In vivo bioavailability was compared following one acute ingestion by monitoring blood magnesium concentrations up to 6 h following intake. The in vitro tests showed a very wide variation in absorption and dissolution of the 15 magnesium products. In the in vivo testing, a significant different serum magnesium absorption profile was found up to 4 h following supplement ingestion for the two supplements with opposing in vitro test results. Moreover, maximal serum magnesium increase and total area under the curve were significantly different for both supplements (+6.2% vs. +4.6% and 6.87 vs. 0.31 mM.min, respectively). Collectively, poor bioaccessibility and bioavailability in the SHIME model clearly translated into poor dissolution and poor bioavailability in vivo. This provides a valid methodology for the prediction of in vivo bioavailability and effectiveness of micronutrients by specific in vitro approaches. Full article
(This article belongs to the Special Issue Dietary Magnesium for Health and Diseases)
Show Figures

Figure 1

10 pages, 231 KiB  
Article
The Association between Dietary Magnesium Intake and Magnetic Resonance Parameters for Knee Osteoarthritis
by Nicola Veronese, Luciana La Tegola, Maria Gabriella Caruso, Stefania Maggi and Giuseppe Guglielmi
Nutrients 2019, 11(6), 1387; https://doi.org/10.3390/nu11061387 - 20 Jun 2019
Cited by 10 | Viewed by 4151
Abstract
The aim of the study was to evaluate the relationship between dietary magnesium (Mg) intake and prevalence of knee osteoarthritis (OA), a topic poorly explored in the literature. Overall, 783 people participating in the Osteoarthritis Initiative (59.8% females; mean age: 62.3 years) and [...] Read more.
The aim of the study was to evaluate the relationship between dietary magnesium (Mg) intake and prevalence of knee osteoarthritis (OA), a topic poorly explored in the literature. Overall, 783 people participating in the Osteoarthritis Initiative (59.8% females; mean age: 62.3 years) and having an MRI assessment were enrolled in this cross-sectional study. Mg intake was measured with a semi-quantitative food frequency questionnaire, and its association with knee OA was evaluated for an increased intake of 100 mg/day. Using an adjusted linear regression analysis, a higher Mg intake (i.e., increase of 100 mg/day) corresponded to a significant increase in mean cartilage thickness, cartilage volume at medial tibia, cartilage volume and mean cartilage thickness at central medial femur, and cartilage volume and mean cartilage thickness in the central medial tibiofemoral compartment. In conclusion, an increased Mg dietary intake is associated with a better knee cartilage architecture, also when adjusting for potential confounders, suggesting a potential role of Mg in the prevention and treatment of knee OA. Full article
(This article belongs to the Special Issue Dietary Magnesium for Health and Diseases)
8 pages, 430 KiB  
Article
Ethnic Differences in Magnesium Intake in U.S. Older Adults: Findings from NHANES 2005–2016
by Sarah E. Jackson, Lee Smith, Igor Grabovac, Sandra Haider, Jacopo Demurtas, Guillermo F. López-Sánchez, Pinar Soysal, Sarah Redsell, Ahmet Turan Isik and Lin Yang
Nutrients 2018, 10(12), 1901; https://doi.org/10.3390/nu10121901 - 04 Dec 2018
Cited by 11 | Viewed by 3667
Abstract
Magnesium plays a crucial role in hundreds of bodily processes relevant to aging, but consumption of dietary magnesium intake has been shown to be inadequate in a large proportion of older adults. Identifying groups at risk of low magnesium intake is important for [...] Read more.
Magnesium plays a crucial role in hundreds of bodily processes relevant to aging, but consumption of dietary magnesium intake has been shown to be inadequate in a large proportion of older adults. Identifying groups at risk of low magnesium intake is important for informing targeted advice. Using data from the National Health and Nutrition Examination Survey (NHANES) 2005–2016, we examined the association between ethnicity (Caucasian/African American/Hispanic/other) and magnesium intake in a large representative sample of U.S. older adults (≥65 y, n = 5682, mean (SD) 72.9 (0.10) y). Analyses adjusted for total energy intake and a range of relevant covariates. Overall, 83.3% of participants were not meeting the recommended level of dietary magnesium intake, ranging from 78.1% of other ethnic groups to 90.6% of African Americans. In the fully adjusted model, magnesium intake was lower among African American older adults (−13.0 mg/d, 95% CI: −18.8 to −7.2), and higher among Hispanics (14.0 mg/d, 95% CI: 7.5 to 20.5) and those from other ethnic groups (17.2, 95% CI: 3.8 to 30.5) compared with Caucasian older adults. These results highlight the need for targeted interventions to increase magnesium intake in U.S. older adults, with a focus on African Americans, in order to reduce the burden of morbidity and ethnic inequalities in health in later life. Full article
(This article belongs to the Special Issue Dietary Magnesium for Health and Diseases)
Show Figures

Figure 1

Back to TopTop