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Gut Microbiota and Malnutrition

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Prebiotics and Probiotics".

Deadline for manuscript submissions: closed (15 December 2019) | Viewed by 30486

Special Issue Editors

1. Department of Health Sciences, Università di Milano, 20122 Milan, Italy
2. Department of Pediatrics, Vittore Buzzi Children’s Hospital, 20154 Milan, Italy
Interests: enteral and parenteral nutrition; neurologically impaired children; childhood obesity; metabolic syndrome; gut microbiota
Special Issues, Collections and Topics in MDPI journals
Microbiologia e Microbiologia Clinica, Università degli Studi di Milano, Milan, Italy
Interests: microbiology and clinical microbiology

Special Issue Information

Dear Colleagues,

The gut microbiota is involved in the regulation of multiple host pathways and participates in metabolic and immune‐inflammatory axes connecting the gut with the liver, muscle, and brain. The gut microbiota co‐develops with its host from birth and is subjected to a complex interplay that is influenced by host genome, nutrition, and lifestyle. The adult human gastrointestinal tract microbiota has been extensively studied in relation to its role in gut homeostasis and in different diseases.

Malnutrition includes undernutrition and overnutrition and is caused by eating a diet in which nutrients are either not enough or too much, thus causing health problems. Undernutrition can result in underweight, while overnutrition can lead to overweight and obesity.

Alterations in the gut microbiome have been associated with the development of obesity, both in children and in adults. In recent years, the prevalence of childhood obesity has increased substantially worldwide. Recent scientific advances implicate the gut microbiota as a contributor to overnutrition.

On the other hand, eating disorders are increasing too, especially in developed countries, and are an important cause of underweight in children and adolescents.

Some studies have demonstrated a different microbial composition in obese and normal-weight subjects, but very little research on this topic has been carried out in patients affected by eating disorders.

In this context, investigating the possible relationship between nutritional status and the microbiota–gut–brain axis could pave the way to develop alternative approaches to modulate the intestinal microbiota (e.g., probiotics, prebiotics), affecting those physiological pathways that are known to be altered in overweight and underweight conditions.

Dr. Elvira Verduci
Dr. Elisa Borghi
Guest Editors

Manuscript Submission Information

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  • gut microbiota
  • obesity
  • overweight
  • underweight
  • undernutrition
  • overnutrition
  • eating disorders

Published Papers (1 paper)

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27 pages, 333 KiB  
Gut Microbiota and Obesity: A Role for Probiotics
Nutrients 2019, 11(11), 2690; - 07 Nov 2019
Cited by 313 | Viewed by 29840
Nowadays, obesity is one of the most prevalent human health problems. Research from the last 30 years has clarified the role of the imbalance between energy intake and expenditure, unhealthy lifestyle, and genetic variability in the development of obesity. More recently, the composition [...] Read more.
Nowadays, obesity is one of the most prevalent human health problems. Research from the last 30 years has clarified the role of the imbalance between energy intake and expenditure, unhealthy lifestyle, and genetic variability in the development of obesity. More recently, the composition and metabolic functions of gut microbiota have been proposed as being able to affect obesity development. Here, we will report the current knowledge on the definition, composition, and functions of intestinal microbiota. We have performed an extensive review of the literature, searching for the following keywords: metabolism, gut microbiota, dysbiosis, obesity. There is evidence for the association between gut bacteria and obesity both in infancy and in adults. There are several genetic, metabolic, and inflammatory pathophysiological mechanisms involved in the interplay between gut microbes and obesity. Microbial changes in the human gut can be considered a factor involved in obesity development in humans. The modulation of the bacterial strains in the digestive tract can help to reshape the metabolic profile in the human obese host as suggested by several data from animal and human studies. Thus, a deep revision of the evidence pertaining to the use probiotics, prebiotics, and antibiotics in obese patients is conceivable Full article
(This article belongs to the Special Issue Gut Microbiota and Malnutrition)
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