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Effect of Lifestyle and Diet for Older Persons' Health

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Geriatric Nutrition".

Deadline for manuscript submissions: closed (20 May 2023) | Viewed by 66133

Special Issue Editors

1. Department of Preventive Medicine and Public Health, University of Granada, 18011 Granada, Spain
2. CIBER Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain
3. Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), 18012 Granada, Spain
Interests: women’s health; lifestyle intervention; patient safety
Special Issues, Collections and Topics in MDPI journals
1. Department of Preventive Medicine and Public Health, University of Granada, 18011 Granada, Spain
2. CIBER Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain
3. Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), 18012 Granada, Spain
Interests: systematic reviews; meta-analysis; nutritional epidemiology; public health
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Despite the outbreak of the COVID-19 pandemic, non-communicable diseases continue to be the leading causes of illness and death worldwide. Their prevalence increases both with age and with successive generations, in parallel with body weight. The progressive westernization of lifestyles—sedentariness, tobacco and alcohol consumption, and the abandonment of traditional eating patterns—form a causal net in which the various risk factors are interrelated and reinforce each other.  

The secondary prevention strategies for the diagnosis and treatment of arterial hypertension, hyperlipidaemia, or type 2 diabetes represent a partial, costly, and inappropriate intervention. There is an urgent need for a comprehensive approach, acting on the fundamental causes that sustain lifestyles that are harmful to health. Aged people are a particularly appropriate target population for intervention strategies. They show the highest risk of disease and the biggest interest in health. They are also particularly susceptible to nutritional deficits and are therefore one of the main groups at high nutritional risk.

This Special Issue of Nutrients is dedicated to bringing together the current state of knowledge on nutritional epidemiology through original articles or reviews on a wide range of public health issues related to the effect of lifestyle and diet on the health of older people.

Dr. Aurora Bueno-Cavanillas
Dr. Naomi Cano-Ibáñez
Guest Editors

Manuscript Submission Information

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Keywords

  • diet
  • lifestyle
  • older persons
  • nutritional epidemiology

Published Papers (19 papers)

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Editorial

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6 pages, 222 KiB  
Editorial
Lifestyle Interventions in an Aged Population: Challenges and Opportunities from a Public Health Perspective
by Naomi Cano-Ibáñez and Aurora Bueno-Cavanillas
Nutrients 2024, 16(1), 173; https://doi.org/10.3390/nu16010173 - 04 Jan 2024
Viewed by 883
Abstract
In recent decades, the prevalence of non-communicable diseases (NCDs) such as obesity, type 2 diabetes mellitus, cancer and cardiovascular disease has increased worldwide [...] Full article
(This article belongs to the Special Issue Effect of Lifestyle and Diet for Older Persons' Health)

Research

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11 pages, 295 KiB  
Article
Sarcopenic Dysphagia Revisited: A Cross-Sectional Study in Hospitalized Geriatric Patients
by Marcel Calles, Rainer Wirth, Bendix Labeit, Paul Muhle, Sonja Suntrup-Krueger, Rainer Dziewas, Gero Lueg and Ulrike Sonja Trampisch
Nutrients 2023, 15(12), 2662; https://doi.org/10.3390/nu15122662 - 07 Jun 2023
Cited by 1 | Viewed by 1771
Abstract
Oropharyngeal dysphagia (OD) is a frequent finding in older patients with potentially lethal complications such as aspiration pneumonia, malnutrition, and dehydration. Recent studies describe sarcopenia as a causative factor for OD, which is occasionally referred to as “sarcopenic dysphagia” in the absence of [...] Read more.
Oropharyngeal dysphagia (OD) is a frequent finding in older patients with potentially lethal complications such as aspiration pneumonia, malnutrition, and dehydration. Recent studies describe sarcopenia as a causative factor for OD, which is occasionally referred to as “sarcopenic dysphagia” in the absence of a neurogenic etiology. In most of the previous studies on sarcopenic dysphagia, the diagnosis was based only on clinical assessment. In this study, flexible endoscopic evaluation of swallowing (FEES) was used as an objective method to evaluate the presence of OD, its association with sarcopenia, and the presence of pure sarcopenic dysphagia. In this retrospective cross-sectional study, 109 acute care geriatric hospital patients with suspected OD received FEES examination and bioimpedance analysis (BIA) in clinical routine. 95% of patients had at least one neurological disease, 70% fulfilled the criteria for sarcopenia, and 45% displayed moderate or severe OD. Although the prevalence of sarcopenia and OD was high, there was no significant association between OD and sarcopenia. Considering these results, both the association between sarcopenia and OD and pure sarcopenic dysphagia appear questionable. Further prospective studies are needed to elucidate if sarcopenia is merely an epiphenomenon of severe disease or whether it plays a causative role in the development of OD. Full article
(This article belongs to the Special Issue Effect of Lifestyle and Diet for Older Persons' Health)
14 pages, 653 KiB  
Article
Urinary Hydration Biomarkers and Water Sources in Older Adults with Neurocognitive Disorder
by Cátia Queirós, Flávia Borges Machado, Duarte Barros, Joana Sampaio, Arnaldina Sampaio, Renata Barros, Pedro Moreira, Óscar Ribeiro, Joana Carvalho and Patrícia Padrão
Nutrients 2023, 15(3), 548; https://doi.org/10.3390/nu15030548 - 20 Jan 2023
Viewed by 1652
Abstract
The risk of dehydration in older adults with neurocognitive disorder (NCD) is controversial. The purpose of this study was to assess hydration status, its determinants, and water intake sources in older adults with NCD. A sample of 30 participants (≥60 years) was included. [...] Read more.
The risk of dehydration in older adults with neurocognitive disorder (NCD) is controversial. The purpose of this study was to assess hydration status, its determinants, and water intake sources in older adults with NCD. A sample of 30 participants (≥60 years) was included. Sociodemographic, clinical data and one 24-h urine sample were collected. Urinary osmolality, sodium, potassium, volume, and creatinine were quantified. Inadequate hydration status corresponded to urine osmolality > 500 mOsm/Kg, or a negative Free Water Reserve (FWR). Two 24-h food recalls were used to assess dietary intake and water sources. The adequacy of total water intake (TWI) was estimated according to EFSA. The contribution of food and beverages to TWI was calculated, and their associations with the urinary osmolality median were tested. Of the total number of participants, 30% were classified as having inadequate hydration status, with no differences between sexes. Regarding TWI, 68.4% of women and 77.8% of men did not reach the reference values. Water (23%), followed by soup (17%), contributed the most to TWI, while vegetables (2%) and alcoholic/other beverages (3%) contributed the least. According to the median urinary osmolality, there was no significant difference in sociodemographic/clinical characteristics. It is critical not to overlook hydration in this vulnerable population. Full article
(This article belongs to the Special Issue Effect of Lifestyle and Diet for Older Persons' Health)
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13 pages, 751 KiB  
Article
Low Sodium Intake, Low Protein Intake, and Excess Mortality in an Older Dutch General Population Cohort: Findings in the Prospective Lifelines-MINUTHE Study
by Niek R. Hessels, Yinjie Zhu, Stephan J. L. Bakker, Martin H. de Borst, Gerjan J. Navis and Ineke J. Riphagen
Nutrients 2023, 15(2), 428; https://doi.org/10.3390/nu15020428 - 13 Jan 2023
Cited by 2 | Viewed by 2492
Abstract
Background: Several studies have found a U-shaped association between sodium intake and mortality. The increased mortality risk of low sodium intake has raised debates and hampers widespread acceptance of public health campaigns and dietary guidelines on reducing sodium intake. Whether the excess risk [...] Read more.
Background: Several studies have found a U-shaped association between sodium intake and mortality. The increased mortality risk of low sodium intake has raised debates and hampers widespread acceptance of public health campaigns and dietary guidelines on reducing sodium intake. Whether the excess risk can be attributed to low sodium intake alone or concomitant inadequate intake of other relevant nutrients is unknown. Objective: We investigated whether concomitant low protein intake could explain the lower part of the U-shaped association of sodium intake with all-cause mortality. Methods: We included 1603 individuals aged between 60 and 75 years old from the gender- and socioeconomic status-balanced prospective Lifelines-MINUTHE cohort study. Using multivariable Cox regression analyses, we investigated the association of sodium intake (24 h urinary sodium excretion) with all-cause mortality, including the interaction with protein intake calculated from the Maroni formula. Results: Mean intakes of sodium and protein were 3.9 ± 1.6 g/day and 1.1 ± 0.3 g/kg/day, respectively. After a median follow-up of 8.9 years, 125 individuals (7.8%) had died. The proportion of participants with insufficient protein intake (<0.8 g/kg/day) was inversely related to sodium intake (i.e., 23.3% in Q1 versus 2.8% in Q4, p < 0.001). We found an increased risk for mortality in both the highest quartile (Q4, >4.7 g/day; hazard ratio (HR) 1.74 (95% confidence interval (CI) 1.03–2.95)) and the lowest two quartiles of sodium intake (Q1, 0.7–2.8 g/day; 2.05 (1.16–3.62); p = 0.01 and Q2, 2.8–3.6 g/day; 1.85 (1.08–3.20); p = 0.03), compared with the third quartile of sodium intake (Q3, 3.6–4.7 g/day). This U-shaped association was significantly modified by protein intake (Pinteraction = 0.006), with the increased mortality risk of low sodium intake being reversed to the lowest mortality risk with concomitant high protein intake. In contrast, the increased mortality risk of low sodium intake was magnified by concomitant low protein intake. Conclusions: We found that a higher protein intake counteracts the increased mortality risk observed in subjects with a low sodium intake. In contrast, a joint low intake of sodium and protein is associated with an increased mortality risk, allegedly due to poor nutritional status. These findings support the guidelines that advocate a lower sodium intake, while highlighting the importance of recognizing overall nutritional status among older adults. Full article
(This article belongs to the Special Issue Effect of Lifestyle and Diet for Older Persons' Health)
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12 pages, 694 KiB  
Article
The Association of Adherence to the Mediterranean Diet with Depression in Older Adults Longitudinally Taking into Account Cognitive Status: Results from the HELIAD Study
by Eirini Mamalaki, Eva Ntanasi, Alexandros Hatzimanolis, Maria Basta, Mary H. Kosmidis, Efthimios Dardiotis, Giorgos M. Hadjigeorgiou, Paraskevi Sakka, Nikolaos Scarmeas and Mary Yannakoulia
Nutrients 2023, 15(2), 359; https://doi.org/10.3390/nu15020359 - 11 Jan 2023
Cited by 10 | Viewed by 2331
Abstract
Although research has generally shown a negative association between depression and adherence to the Mediterranean diet (MeDi), the literature related to older adults is controversial, perhaps partially due to the fact that cognitive status has not been considered. The aim of the current [...] Read more.
Although research has generally shown a negative association between depression and adherence to the Mediterranean diet (MeDi), the literature related to older adults is controversial, perhaps partially due to the fact that cognitive status has not been considered. The aim of the current work was to investigate the association between MeDi and incident depression in a representative cohort of people, taking into account their cognitive status in multiple ways. The sample was drawn from the HELIAD study, a longitudinal study including a follow-up of 3 years after the baseline assessment. In total, 879 participants without depression at baseline were included (55.4% women, mean age ± Standard Deviation: 73.3 ± 5.0 years). Depression was determined as a score in the Geriatric depression scale ≥6 and/or antidepressant medication and/or clinical diagnosis of depression. Cox proportional hazard models adjusted for age, sex and education were employed. In the basic model, adherence to the MeDi was negatively associated with depression. In the most conservative model, excluding participants with dementia and Mild Cognitive Impairment, and after controlling for the baseline Cognitive Status, each unit (range 0–55) increase in MeDi was associated with a 6.2% decrease in the risk for depression (p < 0.001). These findings indicate that MeDi is negatively associated with depression longitudinally in older adults, above and beyond cognitive status. Full article
(This article belongs to the Special Issue Effect of Lifestyle and Diet for Older Persons' Health)
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14 pages, 1740 KiB  
Article
Osteosarcopenic Adiposity and Nutritional Status in Older Nursing Home Residents during the COVID-19 Pandemic
by Selma Cvijetić, Irena Keser, Dario Boschiero and Jasminka Z. Ilich
Nutrients 2023, 15(1), 227; https://doi.org/10.3390/nu15010227 - 01 Jan 2023
Cited by 3 | Viewed by 2367
Abstract
The aim was to evaluate body composition and prevalence of osteosarcopenic adiposity (OSA) in nursing home residents (NHR) and to assess their nutritional status. This research builds on our pilot study (conducted prior COVID-19 pandemic) that revealed high OSA prevalence and poor nutritional [...] Read more.
The aim was to evaluate body composition and prevalence of osteosarcopenic adiposity (OSA) in nursing home residents (NHR) and to assess their nutritional status. This research builds on our pilot study (conducted prior COVID-19 pandemic) that revealed high OSA prevalence and poor nutritional status in NHR. The current study included newly recruited n = 365 NHR; 296 women, 69 men, aged 84.3 ± 5.6 and 83.1 ± 7.3 years, respectively. Body composition was measured by bioelectrical impedance BIA-ACC®, yielding total bone mass along with all components of lean and adipose tissues. The Mini Nutritional Assessment-Short Form (MNA-SF) was used to assess nutritional status. Participants reported about their present/past diseases, including COVID-19. Mean duration of stay in nursing homes was 46.3 ± 47.0 months. Approximately 30% of participants had COVID-19 prior (median 6.7 months) to entering the study. OSA was diagnosed in 70.8% women and 47.8% men (p < 0.001). Malnourishment was detected in 5.8% women and 6.2% men while the risk of malnourishment was found in 30.8% women and 30.0% men. No significant differences in age, body composition parameters, prevalence of OSA, malnutrition/risk for malnutrition were found in participants who had COVID-19 compared to those who did not. Regression analysis showed that intramuscular adipose tissue (%) was significantly positively, while bone mass was significantly negatively associated with OSA. In this population, the high prevalence of OSA coincided with the high prevalence of malnutrition/risk of malnutrition. Such unfavorable body composition status is more likely a consequence of potentially poor diet quality in nursing homes, rather than of health hazards caused by COVID-19. Full article
(This article belongs to the Special Issue Effect of Lifestyle and Diet for Older Persons' Health)
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15 pages, 616 KiB  
Article
Low Serum Vitamin D Status Is Associated with Incident Alzheimer’s Dementia in the Oldest Old
by Debora Melo van Lent, Sarah Egert, Steffen Wolfsgruber, Luca Kleineidam, Leonie Weinhold, Holger Wagner-Thelen, Birgit Stoffel-Wagner, Horst Bickel, Birgitt Wiese, Siegfried Weyerer, Michael Pentzek, Frank Jessen, Matthias Schmid, Wolfgang Maier, Martin Scherer, Steffi G. Riedel-Heller, Alfredo Ramirez and Michael Wagner
Nutrients 2023, 15(1), 61; https://doi.org/10.3390/nu15010061 - 23 Dec 2022
Cited by 6 | Viewed by 3786
Abstract
Background. Vitamins A, D and E and beta-carotene may have a protective function for cognitive health, due to their antioxidant capacities. Methods. We analyzed data from 1334 non-demented participants (mean age 84 years) from the AgeCoDe study, a prospective multicenter-cohort of elderly general-practitioner [...] Read more.
Background. Vitamins A, D and E and beta-carotene may have a protective function for cognitive health, due to their antioxidant capacities. Methods. We analyzed data from 1334 non-demented participants (mean age 84 years) from the AgeCoDe study, a prospective multicenter-cohort of elderly general-practitioner patients in Germany, of whom n = 250 developed all-cause dementia and n = 209 developed Alzheimer’s dementia (AD) during 7 years of follow-up. We examined whether concentrations of vitamins A (retinol), D (25-hydroxycholecalciferol) and E (alpha-tocopherol) and beta-carotene, would be associated with incident (AD) dementia. Results. In our sample, 33.7% had optimum vitamin D concentrations (≥50 nmol/L). Higher concentrations of vitamin D were associated with lower incidence of all-cause dementia and AD (HR 0.99 (95%CI 0.98; 0.99); HR0.99 (95%CI 0.98; 0.99), respectively). In particular, subjects with vitamin D deficiency (25.3%, <25 nmol/L) were at increased risk for all-cause dementia and AD (HR1.91 (95%CI 1.30; 2.81); HR2.28 (95%CI 1.47; 3.53), respectively). Vitamins A and E and beta-carotene were unrelated to (AD) dementia. Conclusions. Vitamin D deficiency increased the risk to develop (AD) dementia. Our study supports the advice for monitoring vitamin D status in the elderly and vitamin D supplementation in those with vitamin D deficiency. We observed no relationships between the other vitamins with incident (AD) dementia, which is in line with previous observational studies. Full article
(This article belongs to the Special Issue Effect of Lifestyle and Diet for Older Persons' Health)
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18 pages, 1693 KiB  
Article
Peripheral Amino Acid Appearance Is Lower Following Plant Protein Fibre Products, Compared to Whey Protein and Fibre Ingestion, in Healthy Older Adults despite Optimised Amino Acid Profile
by Elena de Marco Castro, Giacomo Valli, Caroline Buffière, Christelle Guillet, Brian Mullen, Jedd Pratt, Katy Horner, Susanne Naumann-Gola, Stephanie Bader-Mittermaier, Matteo Paganini, Giuseppe De Vito, Helen M. Roche and Dominique Dardevet
Nutrients 2023, 15(1), 35; https://doi.org/10.3390/nu15010035 - 21 Dec 2022
Cited by 1 | Viewed by 3052
Abstract
Plant-based proteins are generally characterised by lower Indispensable Amino Acid (IAA) content, digestibility, and anabolic properties, compared to animal-based proteins. However, they are environmentally friendlier, and wider consumption is advocated. Older adults have higher dietary protein needs to prevent sarcopenia, a disease marked [...] Read more.
Plant-based proteins are generally characterised by lower Indispensable Amino Acid (IAA) content, digestibility, and anabolic properties, compared to animal-based proteins. However, they are environmentally friendlier, and wider consumption is advocated. Older adults have higher dietary protein needs to prevent sarcopenia, a disease marked by an accelerated loss of muscle mass and function. Given the lower environmental footprint of plant-based proteins and the importance of optimising dietary protein quality among older adults, this paper aims to assess the net peripheral Amino Acid (AA) appearance after ingestion of three different plant protein and fibre (PPF) products, compared to whey protein with added fibre (WPF), in healthy older adults. In a randomised, single-blind, crossover design, nine healthy men and women aged ≥65 years consumed four test meals balanced in AA according to the FAO reference protein for humans, matched for leucine, to optimally stimulate muscle protein synthesis in older adults. A fasted blood sample was drawn at each visit before consuming the test meal, followed by postprandial arterialise blood sampling every 30 min for 3 h. The test meal was composed of a soup containing either WPF or PPF 1–3. The PPF blends comprised pea proteins with varying additional rice, pumpkin, soy, oat, and/or almond protein. PPF product ingestion resulted in a lower maximal increase of postprandial leucine concentration and the sum of branched-chain AA (BCAA) and IAA concentrations, compared to WPF, with no effect on their incremental area under the curve. Plasma methionine and cysteine, and to a lesser extent threonine, appearance were limited after consuming the PPF products, but not WPF. Despite equal leucine doses, the WPF induced greater postprandial insulin concentrations than the PPF products. In conclusion, the postprandial appearance of AA is highly dependent on the protein source in older adults, despite providing equivalent IAA levels and dietary fibre. Coupled with lower insulin concentrations, this could imply less anabolic potential. Further investigation is required to understand the applicability of plant-based proteins in healthy older adults. Full article
(This article belongs to the Special Issue Effect of Lifestyle and Diet for Older Persons' Health)
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12 pages, 635 KiB  
Article
Mediterranean Alcohol-Drinking Patterns and All-Cause Mortality in Women More Than 55 Years Old and Men More Than 50 Years Old in the “Seguimiento Universidad de Navarra” (SUN) Cohort
by María Barbería-Latasa, Maira Bes-Rastrollo, Rafael Pérez-Araluce, Miguel Ángel Martínez-González and Alfredo Gea
Nutrients 2022, 14(24), 5310; https://doi.org/10.3390/nu14245310 - 14 Dec 2022
Cited by 4 | Viewed by 20860
Abstract
Background: Most of the available epidemiological evidence on alcohol and chronic disease agrees on recommending alcohol abstention to young people, but some controversy exists about the most appropriate recommendation for alcohol abstention for people of older ages. A growing body of evidence suggests [...] Read more.
Background: Most of the available epidemiological evidence on alcohol and chronic disease agrees on recommending alcohol abstention to young people, but some controversy exists about the most appropriate recommendation for alcohol abstention for people of older ages. A growing body of evidence suggests that the pattern of alcohol consumption is likely to be a strong effect modifier. The Mediterranean Alcohol Drinking Pattern (MADP) represents a score integrating several dimensions of drinking patterns (moderation, preference for red wine, drinking with meals, and avoiding binge drinking). Our aim was to clarify this issue and provide more precise recommendations on alcohol consumption. Methods: We prospectively followed-up 2226 participants (men older than 50 years and women older than 55 years at baseline) in the Seguimiento Universidad de Navarra (SUN) cohort. We classified participants into three categories of adherence to the MADP score (low, moderate, and high), and we added a fourth category for abstainers. Cox regression models estimated multivariable-adjusted hazard ratios (HR) of all-cause death and 95% confidence intervals (CI) using low MADP adherence as the reference category. Results: The strongest reduction in risk of mortality was observed for those with high adherence to the MADP, with an HR of 0.54 (95% CI: 0.37–0.80). The moderate adherence group (HR = 0.65, 95% CI: 0.44–0.96) and the abstention group (HR = 0.60, 95% CI: 0.36–0.98) also exhibited lower risks of mortality than the low MADP adherence group. Conclusions: based on the available evidence, a public health message can be provided to people older than 50 years as follows: among those who drink alcohol, high adherence to the MADP score could substantially reduce their risk of all-cause mortality. Full article
(This article belongs to the Special Issue Effect of Lifestyle and Diet for Older Persons' Health)
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13 pages, 669 KiB  
Article
The Trajectory of Nutritional Status and Physical Activity before and after Transcatheter Aortic Valve Implantation
by Dennis van Erck, Christine D. Dolman, Wilma J. M. Scholte op Reimer, José P. Henriques, Peter J. M. Weijs, Ronak Delewi and Josje D. Schoufour
Nutrients 2022, 14(23), 5137; https://doi.org/10.3390/nu14235137 - 02 Dec 2022
Cited by 1 | Viewed by 1793
Abstract
It is suggested that older patients waiting for an elective surgical procedure have a poor nutritional status and low physical activity level. It is unknown if this hypothesis is true and if these conditions improve after a medical procedure. We aimed to determine [...] Read more.
It is suggested that older patients waiting for an elective surgical procedure have a poor nutritional status and low physical activity level. It is unknown if this hypothesis is true and if these conditions improve after a medical procedure. We aimed to determine the trajectory of both conditions before and after transcatheter aortic valve implantation (TAVI). Included patients (n = 112, age 81 ± 5 years, 58% male) received three home visits (preprocedural, one and six months postprocedural). Nutritional status was determined with the mini nutritional assessment—short form (MNA-SF) and physical activity using an ankle-worn monitor (Stepwatch). The median MNA-SF score was 13 (11–14), and 27% of the patients were at risk of malnutrition before the procedure. Physical activity was 6273 ± 3007 steps/day, and 69% of the patients did not meet the physical activity guidelines (>7100 steps/day). We observed that nutritional status and physical activity did not significantly change after the procedure (β 0.02 [95% CI −0.03, 0.07] points/months on the MNA-SF and β 16 [95% CI −47, 79] steps/month, respectively). To conclude, many preprocedural TAVI patients should improve their nutritional status or activity level. Both conditions do not improve naturally after a cardiac procedure. Full article
(This article belongs to the Special Issue Effect of Lifestyle and Diet for Older Persons' Health)
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14 pages, 606 KiB  
Article
The Impact of Exercise on Improving Body Composition and PSA in High-Risk Prostate Cancer Patients on Androgen-Deprivation Therapy
by Yu-Ching Lin, I-Hung Shao, Yu-Hsiang Juan, Kun-Yun Yeh, Chen-Pang Hou, Chien-Lun Chen, Kai-Jie Yu, Liang-Sien Chen, Chin-Li Lin and Hai-Hua Chuang
Nutrients 2022, 14(23), 5088; https://doi.org/10.3390/nu14235088 - 30 Nov 2022
Cited by 3 | Viewed by 2033
Abstract
This prospective study investigated how exercise impacted chronological changes in anthropometrics, body composition, prostate-specific antigen (PSA) level and prognostic nutrition index (PNI) in high-risk prostate cancer (PCa) patients on androgen deprivation therapy (ADT). The patients were divided into either the usual care or [...] Read more.
This prospective study investigated how exercise impacted chronological changes in anthropometrics, body composition, prostate-specific antigen (PSA) level and prognostic nutrition index (PNI) in high-risk prostate cancer (PCa) patients on androgen deprivation therapy (ADT). The patients were divided into either the usual care or exercise group. All patients received measurements a week before ADT initiation, six- and twelve months after treatment. The exercise group received both aerobic and resistance training. The analysis was conducted using appropriate statistical methods. There were 45 males enrolled (age 67.4 ± 8 years and BMI 25.5 ± 3.6 kg/m2). Profound changes were observed at six months follow-up. The exercise group showed a significant increase in the trunk and leg lean mass, and a lesser loss of total and arm lean mass. A significant decrease in PSA was also observed among the exercise group. PNI and PSA were significantly associated with regional lean mass. Exercise can prevent loss or even increase lean mass in high-risk PCa, especially in the early stage of ADT treatment. Moreover, a strong bond between lean mass and PNI and PSA further underscores the importance of early and continuous exercise interventions. Full article
(This article belongs to the Special Issue Effect of Lifestyle and Diet for Older Persons' Health)
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14 pages, 438 KiB  
Article
Association between Branched-Chain Amino Acid Intake and Physical Function among Chinese Community-Dwelling Elderly Residents
by Minqi Liao, Yingjun Mu, Xin Su, Lu Zheng, Shiwen Zhang, Hongen Chen, Shan Xu, Junrong Ma, Ruiqing Ouyang, Wanlin Li, Chen Cheng, Jun Cai, Yuming Chen, Changyi Wang and Fangfang Zeng
Nutrients 2022, 14(20), 4367; https://doi.org/10.3390/nu14204367 - 18 Oct 2022
Cited by 1 | Viewed by 1414
Abstract
This study aimed to evaluate the potential associations of dietary BCAAs (isoleucine, leucine, and valine) with physical function in the elderly Chinese population. A validated semiquantitative food frequency questionnaire and anthropometric and physical function measurements were used to collect data. We modeled trends [...] Read more.
This study aimed to evaluate the potential associations of dietary BCAAs (isoleucine, leucine, and valine) with physical function in the elderly Chinese population. A validated semiquantitative food frequency questionnaire and anthropometric and physical function measurements were used to collect data. We modeled trends in physical function indicators for BCAA quartiles using multivariate linear regression models. Among 4336 (43.97% men) participants aged 72.73 ± 5.48 years, a higher dietary intake of BCAAs was positively associated with increased handgrip strength (all p trends < 0.001), shorter times for 4-m fast walking (all p trends < 0.001) and repeated chair rises (all p trends < 0.001). No linear association was found between subtypes of amino acids and any physical functions (all p trends > 0.05). Individuals in the highest quartiles of BCAA intake had a reduced risk of developing low muscle strength, and the multiadjusted odds ratios (ORs) and 95% confidence intervals (95% CIs) for women and men were 0.50 (0.38–0.65) and 0.67 (0.50–0.91), respectively. Similarly, higher BCAA consumption was associated with a lower risk of developing low physical performance (4-m walking speed: OR = 0.68 [0.50–0.93]; repeated chair rises: OR = 0.66 [0.54–0.81]). Higher dietary BCAA intake might be beneficial for physical function in the elderly population. Full article
(This article belongs to the Special Issue Effect of Lifestyle and Diet for Older Persons' Health)
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15 pages, 468 KiB  
Article
The Association of Circulating Amino Acids and Dietary Inflammatory Potential with Muscle Health in Chinese Community-Dwelling Older People
by Yi Su, Amany Elshorbagy, Cheryl Turner, Helga Refsum and Timothy Kwok
Nutrients 2022, 14(12), 2471; https://doi.org/10.3390/nu14122471 - 15 Jun 2022
Cited by 4 | Viewed by 2165
Abstract
Amino acids (AAs) and dietary inflammatory potential play essential roles in muscle health. We examined the associations of dietary inflammatory index (DII) of habitual diet with serum AA profile, and ascertained if the associations between DII and muscle outcomes were mediated by serum [...] Read more.
Amino acids (AAs) and dietary inflammatory potential play essential roles in muscle health. We examined the associations of dietary inflammatory index (DII) of habitual diet with serum AA profile, and ascertained if the associations between DII and muscle outcomes were mediated by serum AAs, in 2994 older Chinese community-dwelling men and women (mean age 72 years) in Hong Kong. Higher serum branched chain AAs (BCAAs), aromatic AAs and total glutathione (tGSH) were generally associated with better muscle status at baseline. A more pro-inflammatory diet, correlating with higher serum total homocysteine and cystathionine, was directly (90.2%) and indirectly (9.8%) through lower tGSH associated with 4-year decline in hand grip strength in men. Higher tGSH was associated with favorable 4-year changes in hand grip strength, gait speed and time needed for 5-time chair stands in men and 4-year change in muscle mass in women. Higher leucine and isoleucine were associated with decreased risk of sarcopenia in men; the associations were abolished after adjustment for BMI. In older men, perturbations in serum sulfur AAs metabolism may be biomarkers of DII related adverse muscle status, while the lower risk of sarcopenia with higher BCAAs may partly be due to preserved BMI. Full article
(This article belongs to the Special Issue Effect of Lifestyle and Diet for Older Persons' Health)
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12 pages, 576 KiB  
Article
Association between Dietary Diversity and All-Cause Mortality: A Multivariable Model in a Mediterranean Population with 18 Years of Follow-Up
by Laura Torres-Collado, Manuela García-de la Hera, Naomi Cano-Ibañez, Aurora Bueno-Cavanillas and Jesús Vioque
Nutrients 2022, 14(8), 1583; https://doi.org/10.3390/nu14081583 - 11 Apr 2022
Cited by 5 | Viewed by 2164
Abstract
We evaluated the relationship between the dietary diversity score (DDS) and all-cause, CVD and cancer mortality in an adult Mediterranean population. We analyzed the data of 1540 participants from the Valencia Nutrition Survey. The DDS was estimated using a validated food frequency questionnaire [...] Read more.
We evaluated the relationship between the dietary diversity score (DDS) and all-cause, CVD and cancer mortality in an adult Mediterranean population. We analyzed the data of 1540 participants from the Valencia Nutrition Survey. The DDS was estimated using a validated food frequency questionnaire and was categorized into quartiles (Q), where the first quartile indicates the lowest dietary diversity. Deaths were ascertained during an 18-year follow-up period. Cox regression models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI). There were 403 deaths during the follow-up period (40% due to CVD). An inverse association was observed between the DDS and all-cause and CVD mortality. Compared with participants in the lowest DDS quartile (Q1), participants in the highest DDS quartile (Q4) showed 32% and 45% less risk of death for all-cause and CVD mortality, in sex- and age-adjusted models, respectively. Regarding the food groups in the DDS, an inverse association was identified between total vegetable consumption diversity and all-cause and CVD mortality in the highest quartiles, (Q3 vs. Q1, HR: 0.70; 95% CI: 0.50, 0.99) and (Q4 vs. Q1, HR: 0.52; 95% CI: 0.30, 0.91), respectively. This study suggests that a higher diversity in food intake, particularly in vegetables, may be associated with a lower risk of all-cause and CVD mortality. This association should be further investigated in other wider populations. Full article
(This article belongs to the Special Issue Effect of Lifestyle and Diet for Older Persons' Health)
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13 pages, 279 KiB  
Article
Protein Intake among Community-Dwelling Older Adults: The Influence of (Pre-) Motivational Determinants
by Marije H. Verwijs, Annemien Haveman-Nies, Jos W. Borkent, Joost O. Linschooten, Annet J. C. Roodenburg, Lisette C. P. G. M. de Groot and Marian A. E. de van der Schueren
Nutrients 2022, 14(2), 293; https://doi.org/10.3390/nu14020293 - 11 Jan 2022
Cited by 2 | Viewed by 1942
Abstract
An adequate protein intake is important for healthy ageing, yet nearly 50% of Dutch community-dwelling older adults do not meet protein recommendations. This study explores protein intake in relation to eight behavioral determinants (I-Change model) among Dutch community-dwelling older adults. Data were collected [...] Read more.
An adequate protein intake is important for healthy ageing, yet nearly 50% of Dutch community-dwelling older adults do not meet protein recommendations. This study explores protein intake in relation to eight behavioral determinants (I-Change model) among Dutch community-dwelling older adults. Data were collected through an online questionnaire from October 2019–October 2020. Protein intake was assessed by the Protein Screener 55+, indicating a high/low chance of a low protein intake (<1.0 g/kg body weight/day). The behavioral determinants of cognizance, knowledge, risk perception, perceived cues, attitude, social support, self-efficacy and intention were assessed by evaluating statements on a 7-point Likert scale. A total of 824 Dutch community-dwelling older adults were included, recruited via online newsletters, newspapers and by personal approach. Poisson regression was performed to calculate quartile-based prevalence ratios (PRs). Almost 40% of 824 respondents had a high chance of a low protein intake. Univariate analyses indicated that lower scores for all different behavioral determinants were associated with a higher chance of a low protein intake. Independent associations were observed for knowledge (Q4 OR = 0.71) and social support (Q4 OR = 0.71). Results of this study can be used in future interventions aiming to increase protein intake in which focus should lie on increasing knowledge and social support. Full article
(This article belongs to the Special Issue Effect of Lifestyle and Diet for Older Persons' Health)
17 pages, 338 KiB  
Article
Food Insecurity Is Associated with the Quality of Diet of Non-Institutionalized Older Adults from a Southern Chilean Commune: A Cross-Sectional Study
by Orietta Segura-Badilla, Ashuin Kammar-García, Addí Rhode Navarro-Cruz, Jacqueline Araneda-Flores, Javier Mancilla-Galindo, Obdulia Vera-López, Martin Lazcano-Hernández and Gladys Quezada-Figueroa
Nutrients 2022, 14(1), 36; https://doi.org/10.3390/nu14010036 - 23 Dec 2021
Cited by 1 | Viewed by 3189
Abstract
As the population ages, greater attention to age-related health problems related to diet and lifestyles is needed. Here, we sought to evaluate the associations between demographic and clinical characteristics and food insecurity with the quality of diet of non-institutionalized elderly from a southern [...] Read more.
As the population ages, greater attention to age-related health problems related to diet and lifestyles is needed. Here, we sought to evaluate the associations between demographic and clinical characteristics and food insecurity with the quality of diet of non-institutionalized elderly from a southern Chilean commune. We performed an analytical cross-sectional study in a sample of 376 older adults. Nutritional status was evaluated through anthropometric measurements. Quality of diet was determined by the healthy eating index (HEI), obtained through the frequency of consumption questionnaire. Socioeconomic, demographic, and lifestyle variables were also collected. Ordinal logistic and Poisson regression models were applied to study associations with quality of diet. The sample consisted of more women (81.6%) than men (18.4%). Most older adults were found to live in a situation of vulnerability or poverty (82.4%), with most having food security (65.7%). According to the HEI, only 14.1% had a good quality of diet, 83.8% had diet in need of improvement, and 2.1% had an unhealthy diet. There was an association of food insecurity and cardiovascular risk (according to waist circumference) with lower quality of diet categories. However, an association with the unhealthy quality of diet category was not confirmed with Poisson regression analysis, which was possibly due to the low number of subjects in that category (n = 8, 2.1%). Other modifiable factors like physical activity, hours of sleep, and polypharmacy were not associated with lower quality of diet categories. Socioeconomic status, which is a structural health determinant, was not associated with decreased quality of diet. Since this was a cross-sectional study performed on a small sample from a Chilean commune, directionality of associations cannot be discerned, and future longitudinal studies could aim to better characterize these associations in larger samples of elderly patients. Full article
(This article belongs to the Special Issue Effect of Lifestyle and Diet for Older Persons' Health)
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Review

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23 pages, 1030 KiB  
Review
Effects of Diet and Lifestyle on Audio-Vestibular Dysfunction in the Elderly: A Literature Review
by Hsin-Lin Chen, Ching-Ting Tan, Chen-Chi Wu and Tien-Chen Liu
Nutrients 2022, 14(22), 4720; https://doi.org/10.3390/nu14224720 - 08 Nov 2022
Cited by 3 | Viewed by 2615
Abstract
Background: The world’s age-related health concerns continue to rise. Audio-vestibular disorders, such as hearing loss, tinnitus, and vertigo, are common complaints in the elderly and are associated with social and public health burdens. Various preventative measures can ease their impact, including healthy food [...] Read more.
Background: The world’s age-related health concerns continue to rise. Audio-vestibular disorders, such as hearing loss, tinnitus, and vertigo, are common complaints in the elderly and are associated with social and public health burdens. Various preventative measures can ease their impact, including healthy food consumption, nutritional supplementation, and lifestyle modification. We aim to provide a comprehensive summary of current possible strategies for preventing the age-related audio-vestibular dysfunction. Methods: A PubMed, Embase, and Cochrane review databases search was conducted to identify the relationship between diet, lifestyle, and audio-vestibular dysfunction. “Diet”, “nutritional supplement”, “lifestyle”, “exercise”, “physical activity”, “tinnitus”, “vertigo” and “age-related hearing loss” were used as keywords. Results: Audio-vestibular dysfunction develops and progresses as a result of age-related inflammation and oxidative stress. Diets with anti-inflammatory and antioxidant effects have been proposed to alleviate this illness. A high-fat diet may induce oxidative stress and low protein intake is associated with hearing discomfort in the elderly. Increased carbohydrate and sugar intake positively correlate with the incidence of audio-vestibular dysfunction, whereas a Mediterranean-style diet can protect against the disease. Antioxidants in the form of vitamins A, C, and E; physical activity; good sleep quality; smoking cessation; moderate alcohol consumption; and avoiding noise exposure are also beneficial. Conclusions: Adequate diet or nutritional interventions with lifestyle modification may protect against developing audio-vestibular dysfunction in elderly individuals. Full article
(This article belongs to the Special Issue Effect of Lifestyle and Diet for Older Persons' Health)
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11 pages, 648 KiB  
Review
Malnutrition in Older Adults—Effect on Falls and Fractures: A Narrative Review
by Malgorzata Kupisz-Urbanska and Ewa Marcinowska-Suchowierska
Nutrients 2022, 14(15), 3123; https://doi.org/10.3390/nu14153123 - 29 Jul 2022
Cited by 7 | Viewed by 3206
Abstract
Malnutrition in older adults impacts health status, increased mortality, and morbidity. Malnutrition may increase the development of geriatric syndromes and contribute to a higher prevalence of falls and osteoporotic fractures that lead to loss of independence and an increased rate of institutionalization. The [...] Read more.
Malnutrition in older adults impacts health status, increased mortality, and morbidity. Malnutrition may increase the development of geriatric syndromes and contribute to a higher prevalence of falls and osteoporotic fractures that lead to loss of independence and an increased rate of institutionalization. The role of malnutrition in the pathogenesis of other geriatric syndromes seems to be well established. However, the data concerning nutritional interventions are confounding. Moreover, long-term undernutrition seems to be one of the factors that strongly influences the efficacy of interventions. This review outlines the current literature on this topic, and aims to guide physicians to make proper decisions to prevent the vicious cycle of falls, fractures, and their negative outcomes in patients with malnutrition. Full article
(This article belongs to the Special Issue Effect of Lifestyle and Diet for Older Persons' Health)
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21 pages, 4421 KiB  
Systematic Review
n-3 PUFA Improve Emotion and Cognition during Menopause: A Systematic Review
by Davide Decandia, Eugenia Landolfo, Stefano Sacchetti, Francesca Gelfo, Laura Petrosini and Debora Cutuli
Nutrients 2022, 14(9), 1982; https://doi.org/10.3390/nu14091982 - 09 May 2022
Cited by 3 | Viewed by 4485
Abstract
Women show an increased risk of cognitive impairment and emotional disorders, such as anxiety and depression, when approaching menopause. Data on risk and protection factors have yielded robust evidence on the effects of lifestyle factors, such as diet, in preserving emotional and cognitive [...] Read more.
Women show an increased risk of cognitive impairment and emotional disorders, such as anxiety and depression, when approaching menopause. Data on risk and protection factors have yielded robust evidence on the effects of lifestyle factors, such as diet, in preserving emotional and cognitive functioning. This review focused on the effects of omega-3 polyunsaturated fatty acids (n-3 PUFA) on anxiety, depression, and cognition during the menopausal transition. This systematic review considered all articles published until 31 December 2021, and the search was performed on two databases, PubMed and Scopus. The fields of interest were “menopause”, “n-3 PUFA” and “emotional and cognitive aspects”. Out of the 361 articles found on PubMed and 283 on Scopus, 17 met inclusion criteria. They encompassed 11 human and 6 animal studies. Most studies reported relieved depressive symptoms in relation to n-3 PUFA intake. While controversial results were found on anxiety and cognition in humans, n-3 PUFA consistently reduced anxiety symptoms and improved cognition in animal studies. Taken together, n-3 PUFA intake shows beneficial effects on emotional and cognitive behaviours during menopause transition. However, further investigations could increase knowledge about the effectiveness of n-3 PUFA on psychological well-being in this delicate period of feminine life. Full article
(This article belongs to the Special Issue Effect of Lifestyle and Diet for Older Persons' Health)
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