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Nutrition and Diet Intervention: The Prevention and Early Treatment of Cognitive Dysfunction

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Geriatric Nutrition".

Deadline for manuscript submissions: closed (20 December 2023) | Viewed by 4645

Special Issue Editors

McKnight Brain Institute and Department of Neuroscience, University of Florida, Gainesville, FL, USA
Interests: cognitive aging; neurophysiology; imaging; diet interventions
Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL, USA
Interests: diet interventions; cognitive aging; Alzheimer’s disease; gut microbiome

Special Issue Information

Dear Colleagues,

We are organizing a Special Issue to collect recent research and ideas on nutritional strategies for preventing or treating cognitive dysfunction. By the year 2050, one quarter of the global population will be older than 65 years of age, and a large proportion of these individuals will suffer cognitive decline that threatens independence, quality of life, and imposes a massive financial burden on both family and health care systems. Thus, developing new strategies for improving late-life cognition is vital. Diet is a modifiable lifestyle factor that can be leveraged as an accessible intervention for the rapidly expanding population of older adults. Recently, there has been an emergence of empirical data that evaluate the potential health benefits of various diet inventions, including therapeutic ketosis, intermittent fasting, the Mediterranean diet, antioxidant-promoting diets, and others. While much of this research was initially conducted in the context of chronic disease management and lifespan studies, there is both theoretical and empirical support for the notion that diet interventions can improve cognition or stall decline.

In this special of issue of Nutrients, we welcome original research articles, animal and clinical studies, as well as review articles on the current state of research that examines diet interventions for preventing or treating cognitive dysfunction associated with advancing age or diseases of the nervous system.

Dr. Sara N. Burke
Dr. Abbi R. Hernandez
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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Research

16 pages, 2737 KiB  
Article
Twelve Months of Time-Restricted Feeding Improves Cognition and Alters Microbiome Composition Independent of Macronutrient Composition
by Abbi R. Hernandez, Cory Watson, Quinten P. Federico, Rachel Fletcher, Armen Brotgandel, Thomas W. Buford, Christy S. Carter and Sara N. Burke
Nutrients 2022, 14(19), 3977; https://doi.org/10.3390/nu14193977 - 24 Sep 2022
Cited by 14 | Viewed by 3829
Abstract
Declining health, gut dysbiosis, and cognitive impairments are hallmarks of advanced age. While caloric restriction is known to robustly extend the healthspan and alter gut microbiome composition, it is difficult maintain. Time-restricted feeding or changes in dietary macronutrient composition could be feasible alternatives [...] Read more.
Declining health, gut dysbiosis, and cognitive impairments are hallmarks of advanced age. While caloric restriction is known to robustly extend the healthspan and alter gut microbiome composition, it is difficult maintain. Time-restricted feeding or changes in dietary macronutrient composition could be feasible alternatives for enhancing late life cognitive and physical health that are easier to comply with for extended periods of time. To investigate this possibility, 8-month-old rats were placed on time-restricted feeding with a ketogenic or micronutrient- and calorically matched control diet for 13 months. A third group of rats was permitted to eat standard chow ad libitum during this time. At 22 months, all rats were tested on a biconditional association task and fecal samples were collected for microbiome composition analysis. Regardless of dietary composition, time-restricted-fed rats had better cognitive performance than ad libitum-fed rats. This observation could not be accounted for by differences in motivation, procedural or sensorimotor impairments. Additionally, there were significant differences in gut microbiome diversity and composition between all diet conditions. Allobaculum abundance was associated with cognitive task performance, indicating a link between gut health and cognitive outcomes in aged subjects. Overall, time restricted feeding had the largest influence on cognitive performance in aged rats. Full article
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