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Interactions between Bioactive Phytochemicals and Gut Microbiota, and Their Influence on Metabolic Health

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Phytochemicals and Human Health".

Deadline for manuscript submissions: closed (5 May 2024) | Viewed by 302

Special Issue Editors

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Guest Editor
Department of Food Science and Nutrition, The Hong Kong Polytechnic University, Hong Kong 999077, China
Interests: polyphenol; phytochemical; functional gut bacteria; probiotics; phytochemical–gut microbiota interaction; metabolic disease; mass spectrometry-based metabolomics
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Food Science and Technology, National University of Singapore, Singapore 117542, Singapore
Interests: polyphenols; phytochemical bioavailability and metabolism; phytochemical–gut microbiota interaction; metabolic disorders; metabolomics; precision nutrition

Special Issue Information

Dear Colleagues,

Phytochemicals are naturally occurring secondary metabolites ubiquitously present in foods of plant origin and medicinal herbs. They have been arousing sustained research interest due to their multifarious bioactivities and cost-effectiveness. Despite having tremendous medicinal values, many of them, e.g., polyphenols and terpenoids, show extremely poor intestinal absorptivity and bioavailability. In consequence, the majority of the orally ingested phytochemicals enter the colon where they encounter the gut microbiota and are bio-transformed into bioactive and bioavailable metabolites. On top of this, the precursor phytochemicals together with their microbial metabolites exert great impacts on the residential microbial community. Such complex and intriguing phytochemical–microbiota interactions concertedly exert profound impacts on multiple health domains of the host, especially the metabolic systems.

For this Special Issue, we invite the submission of research articles and reviews that focus on, but are not limited to, the following topics:

  • The metabolic pathways of bioactive phytochemicals in vivo (particularly gut microbiota catabolic activities).
  • The keystone/functional strains of gut microbiota responsible for the biotransformation of phytochemicals into bioactive metabolites.
  • The interplay between bioactive phytochemicals and gut microbiota, and the associated effects on metabolic health.
  • The causal relationship between gut microbiota and the bio-efficacy of phytochemicals in altering metabolic conditions and the underlying mechanisms.
  • Dietary intervention strategies incorporating bioactive phytochemicals for improving metabolic health conditions.
  • Translational applications of bioactive phytochemicals for enhancing resilience towards metabolic disorders via targeting the gut microbiota.
  • Advanced omics techniques (metabolomics, proteomics, metagenomics, and transcriptomics) that help to dissect the phytochemical–microbiota interactions.
  • Novel in vitro systems developed for exploring the phytochemical–microbiota interactions.

Dr. Danyue Zhao
Dr. Quancai Sun
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • phytochemical
  • gut microbiota
  • metabolism
  • microbial metabolite
  • bio-efficacy
  • metabolic health
  • multi-omics

Published Papers

There is no accepted submissions to this special issue at this moment.
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