Dear Colleagues,

Anti-aging therapies aim to delay (or even reverse) the cellular aging process, in order to increase not only lifespan, but especially the age at which the first chronic diseases appear. The key objectives of anti-aging therapies are as follows: reducing the level of free radicals, fighting inflammation, detoxifying the body, strengthening immunity, eliminating senescent cells, and improving cellular functions (mitochondrial respiration, metabolism, etc.). Unfortunately, increasing the lifespan in the context of a problematic lifestyle has not brought more happiness—the result has been quite the opposite. The appearance of chronic disease at an early age leads to a decrease in the quality of life and to disabilities that can make life a continuous struggle with the disease. In this context, the goal of anti-aging interventions is to delay preclinical aging (i.e., cellular aging), so that the disease is as short as possible in a person's life, until the time when his biological clock stops.

Nutrition is an essential element in maintaining optimal health, and is also a factor that can significantly influence the aging process. Anti-aging therapy emphasizes the use of an adequate diet that counteracts the effect of free radicals, ensures optimal detoxification of the body, reduces inflammatory processes, strengthens the immune system, provides essential nutrients for stimulating regenerative processes, and prevents caloric excess.

Modern nutritional theories are based on nutritional genetics, which studies the molecular genetic mechanisms through which diet predisposes to chronic diseases and premature aging through its two branches: nutrigenetics and nutrigenomics.

Nutrigenetics focuses on the study of how individual genetic characteristics affect the response to nutrients (the relationship between genes and nutrition, individual metabolism, living environment and individual predispositions), thus having an important role in determining the personalized nutritional regime.

Nutrigenomics studies the effect of food and food constituents on gene expression, establishing the correlation between gene expression and the absorption, metabolism, elimination and biological effects of nutrients, having an important role in establishing personalized nutrition according to genotype.

This Special Issue will also focus on the structure–property relationships of food constituents are necessary to establish a correlation between nutrition, foods, or supplements and life quality.

In this Special Issue, theoretical and experimental contributions in the form of full-length original research articles, literature reviews, and short communications are kindly welcome.

We welcome and look forward to your submissions.

Dr. Magdalena Mititelu
Prof. Dr. Doina Drǎgǎnescu
Dr. Adina Magdalena Musuc
Guest Editors

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• antioxidants
• functional foods
• cellular regeneration
• immunoprotection
• anti-inflammatory nutrition
• alkalizing nutrition
• neuroprotective
• combating oxidative stress
• detoxifying food
• nutrigenetics
• nutrigenomics
• healthy lifespan extension
• natural products
• antiaging agents
• bioactive compounds
• physico-chemical characterization