Nutraceuticals and Their Anti-inflammatory Effects

A special issue of Nutraceuticals (ISSN 1661-3821).

Deadline for manuscript submissions: 31 May 2024 | Viewed by 3180

Special Issue Editors


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Guest Editor
1. Drugs Research Laboratory, Federal University of Amapá, Macapá 68902-280, Brazil
2. University Hospital of the Federal University of Amapá, Macapá 68902-280, Brazil
Interests: nutraceutical from the Amazonian; dyslipidemie; anti-inflammatory; anxiolytic; antidepressant; alternative methods
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Guest Editor
Department of Biological and Health Sciences, Federal University of Amapá, Campus Marco Zero, Macapá, 68903-419, Brazil
Interests: phytopharmaceutical nanobiotechnology; nano-emulsions; nanodispersions; essential oils; amazon oils; terpenes
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The potential therapeutic benefits of nutraceuticals, especially their anti-inflammatory effects, have garnered significant attention in recent years. Inflammation plays a central role in numerous chronic diseases, and nutraceuticals present a natural approach to combating this pervasive issue. In this issue of the Journal Nutraceuticals "Nutraceuticals and Their Anti-inflammatory Effects", we will be accepting manuscripts that describe neutraceuticas that possess anti-inflammatory properties, the mechanisms through which they operate, and their implications for health and disease prevention, in addition to the following related topics:

  1. Active raw materials from the Amazon for application as anti-inflammatory nutraceuticals;
  2. Modulation of inflammatory diseases by the use of nutraceuticals;
  3. Modulatory mechanisms of action of nutraceuticals on skin disorders;
  4. In silico studies on the safety and efficacy of anti-inflammatory nutraceuticals;
  5. Application of nutraceuticals in the modulation of dynapenia and sarcopenia;
  6. Perspectives on the use of nutraceuticals in inflammatory metabolic syndromes;
  7. Non-clinical pharmacotoxicological validation of anti-inflammatory nutraceuticals;
  8. Regulatory processes for registration of nutraceuticals.

These are just some broad sub-topics within the theme of "Nutraceuticals and Their Anti-inflammatory Effects". Each of these can be explored in depth, with specific studies, research findings, and expert opinions to provide a comprehensive view on the topic.

Prof. Dr. José Carlos Tavares Carvalho
Dr. Caio Pinho Fernandes
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutraceuticals is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (3 papers)

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Research

18 pages, 3190 KiB  
Article
Osteoprotective Effect of the Phytonutraceutical Ormona® on Ovariectomy-Induced Osteoporosis in Wistar Rats
by Aline Lopes do Nascimento, Gabriel da Costa Furtado, Vinicius Maciel Vilhena, Helison de Oliveira Carvalho, Priscila Faimann Sales, Alessandra Ohana Nery Barcellos, Kaio Coutinho de Maria, Francinaldo Sarges Braga, Heitor Ribeiro da Silva, Roberto Messias Bezerra and José Carlos Tavares Carvalho
Nutraceuticals 2024, 4(2), 147-164; https://doi.org/10.3390/nutraceuticals4020010 - 22 Mar 2024
Viewed by 612
Abstract
The phytonutraceutical Ormona® is a product composed of purified oil of Bixa orellana Linné, dry extract of Myrciaria dubia McVaugh, dry extract of Trifolium pratense L., and dry extract of Euterpe oleracea Mart. obtained using Evolve® technology. This study evaluated the [...] Read more.
The phytonutraceutical Ormona® is a product composed of purified oil of Bixa orellana Linné, dry extract of Myrciaria dubia McVaugh, dry extract of Trifolium pratense L., and dry extract of Euterpe oleracea Mart. obtained using Evolve® technology. This study evaluated the effects of Ormona® on Wistar rats affected by ovariectomy-induced osteoporosis. Pre-treatment was conducted for 15 days before surgery and continued for a further 45 days after the surgical procedure. The experimental design consisted of five groups (n = 5): OVW: treated with distilled water (1 mL/kg, p.o); ADS: alendronate sodium (4 mg/kg p.o); EST: conjugated estrogen (2 µg/kg, p.o); ORM: Ormona® (20 mg/kg, p.o); ORM + EST: Ormona® (20 mg/kg, p.o) + conjugated estrogen (2 µg/kg, p.o). Biochemical and hormonal parameters of bone histopathology and trabecular and femoral diaphysis size were evaluated through scanning electron microscopy (SEM) and bone calcium quantification by atomic absorption spectrophotometry. The results show that ovariectomy caused bone alterations such as loss of femoral microarchitecture, decreased bone homeostasis parameters, and changes in the lipid profile. Estrogen supplementation reduced parameters such as cholesterol, LDL, and Ca2+ concentration. However, Ormona® showed higher serum estradiol levels (p < 0.01), effects on the lipid profile, including parameters that estrogen replacement and alendronate sodium did not affect, with an increase in HDL, and positive modulation of bone metabolism, increasing osteocytes and the presence of osteoblasts. Ormona®, therefore, produced better results than the groups treated with estrogen and alendronate sodium. Full article
(This article belongs to the Special Issue Nutraceuticals and Their Anti-inflammatory Effects)
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20 pages, 3253 KiB  
Article
Investigation of the In Vitro Immunomodulatory Effects of Extracts from Green-Lipped Mussels (Perna canaliculus)
by Roberta Cardim Lessa, Belgheis Ebrahimi, Hui Li, Xiao Guan, Yan Li and Jun Lu
Nutraceuticals 2024, 4(1), 127-146; https://doi.org/10.3390/nutraceuticals4010009 - 15 Mar 2024
Cited by 1 | Viewed by 851
Abstract
The immune system plays a crucial role in defending the body against foreign invaders, and the balance of various polyunsaturated fatty acids, such as alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), can impact immune cell functions and overall immune responses. [...] Read more.
The immune system plays a crucial role in defending the body against foreign invaders, and the balance of various polyunsaturated fatty acids, such as alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), can impact immune cell functions and overall immune responses. This study aimed to assess the effectiveness of mussel oil extracts in modulating inflammatory responses by analysing their effects on immune cell lines and cytokine expression. Four different mussel oil extracts were obtained using two extraction methods (organic solvent and supercritical CO2 extraction) from two tissue sources (fresh and commercial). These extracts were then tested at various concentrations on T lymphocyte (Jurkat) cells, monocytes, and macrophages (THP-1 and U-937). Cytokine levels were quantified using ELISA. The results showed that the solvent-extracted samples had a dose-dependent effect on tumour necrosis factor alpha (TNF-α) and interleukin-1 beta (IL-1β) cytokine secretion in THP-1 and U937 cells, with the extract from a commercial mussel powder being more efficient than the extract from fresh powder. However, supercritical CO2 samples showed elevated cytokine secretion levels despite their high omega-3 content. Furthermore, 100 ug/mL extract from fresh powder successfully reduced interleukin-2 (IL-2) secretion while maintaining cell viability after stimulation. The study demonstrated that solvent-extracted mussel oil can effectively regulate cytokine secretion, modulate immune cell activation, and alleviate inflammation. These findings offer valuable insights into using mussel oil extracts to treat inflammatory disorders and enhance immune responses. Full article
(This article belongs to the Special Issue Nutraceuticals and Their Anti-inflammatory Effects)
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22 pages, 5408 KiB  
Article
Exploring the In Vitro Protective Effects of Green-Lipped Mussel (GLM) Oil Extract against Biomarkers of Glucose Metabolism and Inflammation in Chondrocyte Cells
by Roberta Cardim Lessa, Belgheis Ebrahimi, Xiao Guan, Yan Li and Jun Lu
Nutraceuticals 2024, 4(1), 1-22; https://doi.org/10.3390/nutraceuticals4010001 - 19 Dec 2023
Cited by 2 | Viewed by 1201
Abstract
Chondrocyte behavior is critical in osteoarthritis (OA) progression and cartilage deterioration. Recent studies have shown that green-lipped mussel (GLM) oil extracts obtained through solvent extraction can regulate cytokine secretion in cell lines, potentially reducing inflammation and immune cell activation. This study investigates the [...] Read more.
Chondrocyte behavior is critical in osteoarthritis (OA) progression and cartilage deterioration. Recent studies have shown that green-lipped mussel (GLM) oil extracts obtained through solvent extraction can regulate cytokine secretion in cell lines, potentially reducing inflammation and immune cell activation. This study investigates the effects of these extracts on human chondrocyte cell lines to understand their impact on osteoarthritis development. Chondrocyte cultures exposed to osteoarthritis-related inflammatory factors were treated with various concentrations of GLM oil. The results revealed that mussel oils, particularly a commercial mussel powder extract (SOLV.COM), enhance glucose uptake and protect chondrocyte cells. SOLV.COM effectively manages the release of inflammatory markers like interleukin-6 (IL-6) and matrix metalloproteinases-3 (MMP-3), showing increased deoxyglucose uptake. This study highlights the significant influence of extract choice on managing interleukin-6 (IL-6) secretion and cellular activation pathways, demonstrating the potential of SOLV.COM in managing osteoarthritis by controlling reactive oxygen production, regulating glucose metabolism, and inflammatory markers. Full article
(This article belongs to the Special Issue Nutraceuticals and Their Anti-inflammatory Effects)
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