Special Issue "Plasticity in the Visual and Other Systems: Energy Metabolism, Neurochemical and Physiological Bases—Honorary Special Issue Commemorating the Work of Prof. Margaret Wong-Riley"

A special issue of NeuroSci (ISSN 2673-4087).

Deadline for manuscript submissions: 31 October 2023 | Viewed by 210

Special Issue Editor

Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Interests: neuroscience; cancer; epigenetics; mitochondria; energy metabolism; neuronal activity; visual system; respiratory system; cytochrome c oxidase
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Special Issue Information

Dear Colleagues,

The forthcoming year of 2023 marks the 40-year anniversary of the acceptance of a manuscript by Prof. Emeritus Margaret Wong-Riley, titled “Effect of impulse blockage on cytochrome oxidase activity in monkey visual system” (Nature, 1984, 307 (5948), 262–264), which opened up a new field within the topic of visual systems. Starting from visual system and its metabolic biomarker cytochrome c oxidase, Prof Wong-Riley’s research interests expanded into the regulation of energy metabolism in neurons and in the coupling of neuronal activity and energy metabolism at the cellular and molecular levels. Her laboratory uncovered a transcriptional coupling in neurons, whereby the same sets of transcription factors regulate mediators of energy metabolism (cytochrome c oxidase) and of synaptic transmission (glutamatergic receptors). Her laboratory also uncovered a critical period of respiratory development in rats, during which abrupt neurochemical, ventilatory, and electrophysiological changes occur and animals are least responsive to respiratory insults, such as hypoxia, during that time. Recently, her laboratory discovered that during the critical period of the rat’s visual cortex, there is also a distinct synaptic imbalance with heightened inhibition and suppressed excitation and a reduced expression of brain-derived neurotrophic factor (BDNF). These changes are parallel to those in the brain stem respiratory system, though differ in time and duration, indicating that synaptic imbalance during the critical period is a general but necessary transitional phenomenon among systems.

Her research interests include the molecular mechanisms of the bigenomic regulation of cytochrome c oxidase in neurons; adult plasticity in the visual system; metabolic, neurochemical, and physiological bases of a critical period of respiratory development; therapeutic effect of near-infrared light on visual cortical neurons exposed to toxins; and tight coupling of energy metabolism and neuronal activity at the transcriptional level. Her research has been funded by NIH since 1976, and she has published over 138 peer-reviewed articles, including book chapters and invited reviews.

You may choose our Joint Special Issue in Biomolecules.

Dr. Shilpa Dhar
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. NeuroSci is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • visual system
  • energy metabolism
  • neuronal activity
  • respiratory system
  • transcription
  • molecular neuroscience

Published Papers

This special issue is now open for submission.
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