Special Issue "Recent Advances in Brain Aging and Dementia"

A special issue of NeuroSci (ISSN 2673-4087).

Deadline for manuscript submissions: closed (30 April 2023) | Viewed by 2250

Special Issue Editor

International Center for Neuroscience Research, 0179 Tbilisi, Georgia
Interests: adolescent development; animal cognition and behavior; behavioral pharmacology; stress and the brain; learning and memory; neurophysiology; neurodegenerative disorders

Special Issue Information

Dear Colleagues,

One of the biggest challenges associated with the aging population is dementia. The World Alzheimer reported that the number of people living with dementia could triple to 132 million worldwide by 2050. Dementia, particularly Alzheimer’s disease (AD), is a growing pandemic that presents profound challenges to healthcare systems, families, and societies worldwide. Brain aging is associated with patterns of functional and structural changes. To reduce the risk of dementia in the future, there is an immediate need for interventions that target the disease process from its earliest stages. Research programs are increasingly focusing on midlife as a critical period for the beginning of AD-related pathology. However, early disease process indicators in asymptomatic individuals are still poorly understood. In this Special Issue, we welcome reviews, short communications, and original research articles highlighting the molecular and cellular mechanisms and therapeutic strategies for brain aging and dementia. All articles submitted to this Issue should be original, never previously published in any journal, or presented at a conference. Submitted papers should meet the internationally accepted criteria and manuscripts should follow the journal style for both reviewing and editing.

Dr. Nasrollah Moradikor
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. NeuroSci is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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Research

Article
Investigation of the Neuroprotective Action of Japanese Sake Yeast on Dementia Type of Alzheimer Disease in Rats: Behavioral and Neurobiochemical Assessment
NeuroSci 2023, 4(1), 45-53; https://doi.org/10.3390/neurosci4010006 - 19 Jan 2023
Cited by 1 | Viewed by 1817
Abstract
Dementia involves several factors, and it is required to administer an agent with several efficiencies for its treatment. Sake is known to have antioxidant and anti-inflammatory properties and improves the serum concentration of BDNF. This study aimed to evaluate the neuroprotective action of [...] Read more.
Dementia involves several factors, and it is required to administer an agent with several efficiencies for its treatment. Sake is known to have antioxidant and anti-inflammatory properties and improves the serum concentration of BDNF. This study aimed to evaluate the neuroprotective action of Japanese sake yeast on dementia of the Alzheimer disease type in rats by behavioral evaluation and neurobiochemical assessment. The rats were grouped as non-Alzheimer rats (control rats) and Alzheimer rats administrated with 0 (AD), 10 (10-AD), 20 (20-AD), 30 (30-AD), and 40 mg/kg (40-AD) of sake. Anxiety-like and depression-like behaviors, the concentrations of brain-derived neurotrophic factor (BDNF), malondialdehyde (MDA), and ferric reducing ability of plasma (FRAP) were evaluated. The expressions of IL-1β, TNF-α, and IL-6 were assessed. The results showed that Alzheimer disease caused anxiety-like and depression-like behaviors (p = 0.000), decreased the concentrations of BDNF (p = 0.000) and FRAP (p = 0.000), increased the concentration of MDA (p = 0.000), and increased the expressions of IL-1β (p = 0.000), TNF-α (p = 0.000), and IL-6 (p = 0.000). The results showed that oral gavage of sake in higher doses decreased anxiety-like and depression-like behaviors (p = 0.000), increased the concentrations of BDNF (p = 0.000) and FRAP (p = 0.000), and reduced the concentration of MDA (p = 0.000) and the expressions of IL-1β (p = 0.000), TNF-α (p = 0.000), and IL-6 (p = 0.000). In sum, Japanese sake yeast can have roles in treating dementia of the Alzheimer disease type, but its mechanisms must be assessed in future studies. Full article
(This article belongs to the Special Issue Recent Advances in Brain Aging and Dementia)
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