Dear Colleagues,

After damage, neuronal production can be re-established to restore specific functions in the central nervous system (CNS). In adult neurogenesis, neurons are generated and integrated into the circuits system in the vertebrate brain. Adult neurogenesis not only supports learning and memory but also regenerates neurons lost to disease or injury in some species. Therefore, understanding the mechanism(s) and role of neuroglia involved in neuronal regeneration can bring fundamental insight into cell plasticity, reprogramming and stem cell fate in the physiological condition, thus providing a context for the therapeutic repair of lesions and reversal of degenerative events.

In most mammals, adult neurogenesis is confined to the major neurogenic niches of two different brain regions. Specifically, newborn neurons are generated in the subventricular (SV) zone of the lateral ventricle before they migrate to the olfactory bulb. Adult neurogenesis is also confined to the subgranular (SG) zone of the hippocampal dentate gyrus. Outside of these zones, integration of newborn neurons is essentially absent. Indeed, except for the SV and SG zones, regions outside these areas display low potential for the integration and survival of newborn neurons, even after injury-induced neuronal cell death. This limited capability of reprogram neuron integration in most CNS areas represents a significant roadblock against CNS repair in mammals after injury or neurodegeneration.

The purpose of this Special Issue is to receive original research articles and reviews that focus on unraveling (1) the different roles of the neuroglia, which might have different roles and mechanisms involved in reprogram process after spinal cord injury (SCI); (2) a better understanding of mechanisms underlying neurogenesis and neuron integration in order to develop therapeutic strategies at the cellular level. We believe that this Special Issue can provide new insight into the current understanding of neurogenesis and regenerative medicine after SCI.

Dr. Chih-Wei Zeng
Dr. Jan Kaslin
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Neuroglia is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• spinal cord injury
• regenerative medicine
• stem cell fate
• astrocyte