Non-Coding RNA and Intracellular Structures
A special issue of Non-Coding RNA (ISSN 2311-553X).
Deadline for manuscript submissions: closed (31 March 2020) | Viewed by 71429
Interests: lncRNAs; RNP complex; Cell organization by liquid phase separation
Multiple non-coding RNAs (ncRNAs) can be found in various intracellular structures, where they perform regulatory functions by recruiting specific proteins, RNAs, and chromatin loci. Some of these ncRNAs are present in heterochromatins and regulate their formation and/or maintenance by recruiting specific epigenetic regulatory proteins to the site of their accumulation. Other ncRNAs act as structural scaffolds of intracellular bodies without membranes by sequestering a specific set of RNA-binding proteins that contain an intrinsically-disordered domain, which triggers the liquid–liquid phase transition or hydrogel formation under certain conditions. Other ncRNAs have been reported to preferentially interact with a non-classical binding partner, such as membrane-lipids. The accumulating evidence regarding the distribution and interaction partners of ncRNAs suggest that ncRNAs localized in intracellular structures arrange the formation of a specific microenvironment consisting of the ncRNAs and their binding proteins around the respective ncRNA molecules. This Special Issue on non-coding RNAs and intracellular structures aims to unravel the diverse roles of ncRNAs in the formation and regulation of RNA-related intracellular structures, especially focusing on the molecular mechanisms and the physiological consequences.
Prof. Tetsuro Hirose
Prof. Shinichi Nakagawa
Manuscript Submission Information
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- non-coding RNA
- nuclear bodies
- RNP complex
- phase separation
- animal model