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Nanomaterials
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Advances in Nanoscale Materials in Biomedicine
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Advances in Nanoscale Materials in Biomedicine

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: closed (10 October 2023) | Viewed by 12168

Special Issue Editor

Prof. Dr. Elena I. Ryabchikova

E-Mail Website
Guest Editor
Institute of Chemical Biology and Fundamental Medicine SB RAS, 630090 Novosibirsk, Russia
Interests: nanoparticles; nucleic acid delivery; electron microscopy; viruses; cell structure; spheroid models
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Cancer remains a severe and frightening disease throughout the world, as evidenced by relentless statistics from WHO: in 2020, there were 19.3 million new cases of cancer and almost 10 million deaths. To defeat this scourge, science uses all possible approaches and methods, among which the arsenal of nanomaterials occupies an increasingly significant place. Gold and silver nanoparticles occupy not the last place in this arsenal; numerous articles have been published concerning their use for the treatment and diagnosis of cancer. The special issue "Gold and Silver nanoparticles in the treatment and diagnosis of cancer" can serve as a good platform for collecting and analyzing new data on the use of these nanoparticles for the diagnosis and treatment of cancer.

All types of submission are invited to be presented in a Special Issue of "Advances in Nanoscale Materials in Biomedicine" to show new achievements and experts' views on the state of affairs and prospects for the development of this branch of nanotechnology.

We hope that this Special Issue can serve as a kind of interdisciplinary get-together, allowing to discuss both current news in the field of gold and silver nanoparticles use in the treatment and diagnosis of cancer, and experimental developments aimed at creating new tools and methods for the treatment and diagnosis of cancer using these nanoparticles.

We welcome original research articles and reviews, communications and short letters devoted to medical and experimental research on gold and silver nanoparticles application in cancer treatment and diagnosis. 

Prof. Dr. Elena I. Ryabchikova
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gold nanoparticles
  • cancer treatment and diagnostics
  • silver nanoparticles
  • experimental models to study effect of gold and silver nanoparticles
  • biomedicine

Published Papers (7 papers)

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Research

Jump to: Review

20 pages, 6104 KiB  
Article
Monocyte (THP-1) Response to Silver Nanoparticles Synthesized with Rumex hymenosepalus Root Extract
by Francisco Javier Alvarez-Cirerol, José Manuel Galván-Moroyoqui, Ericka Rodríguez-León, Carmen Candía-Plata, César Rodríguez-Beas, Luis Fernando López-Soto, Blanca Esthela Rodríguez-Vázquez, José Bustos-Arriaga, Adriana Soto-Guzmán, Eduardo Larios-Rodríguez, Juan M. Martínez-Soto, Aaron Martinez-Higuera and Ramón A. Iñiguez-Palomares
Nanomaterials 2024, 14(1), 106; https://doi.org/10.3390/nano14010106 - 02 Jan 2024
Viewed by 1366
Abstract
The study, synthesis, and application of nanomaterials in medicine have grown exponentially in recent years. An example of this is the understanding of how nanomaterials activate or regulate the immune system, particularly macrophages. In this work, nanoparticles were synthesized using Rumex hymenosepalus as [...] Read more.
The study, synthesis, and application of nanomaterials in medicine have grown exponentially in recent years. An example of this is the understanding of how nanomaterials activate or regulate the immune system, particularly macrophages. In this work, nanoparticles were synthesized using Rumex hymenosepalus as a reducing agent (AgRhNPs). According to thermogravimetric analysis, the metal content of nanoparticles is 55.5% by weight. The size of the particles ranges from 5–26 nm, with an average of 11 nm, and they possess an fcc crystalline structure. The presence of extract molecules on the nanomaterial was confirmed by UV-Vis and FTIR. It was found by UPLC-qTOF that the most abundant compounds in Rh extract are flavonols, flavones, isoflavones, chalcones, and anthocyanidins. The viability and apoptosis of the THP-1 cell line were evaluated for AgRhNPs, commercial nanoparticles (AgCNPs), and Rh extract. The results indicate a minimal cytotoxic and apoptotic effect at a concentration of 12.5 μg/mL for both nanoparticles and 25 μg/mL for Rh extract. The interaction of the THP-1 cell line and treatments was used to evaluate the polarization of monocyte subsets in conjunction with an evaluation of CCR2, Tie-2, and Arg-1 expression. The AgRhNPs nanoparticles and Rh extract neither exhibited cytotoxicity in the THP-1 monocyte cell line. Additionally, the treatments mentioned above exhibited anti-inflammatory effects by maintaining the classical monocyte phenotype CD14++CD16, reducing pro-inflammatory interleukin IL-6 production, and increasing IL-4 production. Full article
(This article belongs to the Special Issue Advances in Nanoscale Materials in Biomedicine)
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15 pages, 4047 KiB  
Article
Targeting of Tomato Bushy Stunt Virus with a Genetically Fused C-End Rule Peptide
by Luca Marchetti, Lorena Simon-Gracia, Chiara Lico, Mariateresa Mancuso, Selene Baschieri, Luca Santi and Tambet Teesalu
Nanomaterials 2023, 13(8), 1428; https://doi.org/10.3390/nano13081428 - 21 Apr 2023
Cited by 1 | Viewed by 1664
Abstract
Homing peptides are widely used to improve the delivery of drugs, imaging agents, and nanoparticles (NPs) to their target sites. Plant virus-based particles represent an emerging class of structurally diverse nanocarriers that are biocompatible, biodegradable, safe, and cost-effective. Similar to synthetic NPs, these [...] Read more.
Homing peptides are widely used to improve the delivery of drugs, imaging agents, and nanoparticles (NPs) to their target sites. Plant virus-based particles represent an emerging class of structurally diverse nanocarriers that are biocompatible, biodegradable, safe, and cost-effective. Similar to synthetic NPs, these particles can be loaded with imaging agents and/or drugs and functionalized with affinity ligands for targeted delivery. Here we report the development of a peptide-guided Tomato Bushy Stunt Virus (TBSV)-based nanocarrier platform for affinity targeting with the C-terminal C-end rule (CendR) peptide, RPARPAR (RPAR). Flow cytometry and confocal microscopy demonstrated that the TBSV-RPAR NPs bind specifically to and internalize in cells positive for the peptide receptor neuropilin-1 (NRP-1). TBSV-RPAR particles loaded with a widely used anticancer anthracycline, doxorubicin, showed selective cytotoxicity on NRP-1-expressing cells. Following systemic administration in mice, RPAR functionalization conferred TBSV particles the ability to accumulate in the lung tissue. Collectively, these studies show the feasibility of the CendR-targeted TBSV platform for the precision delivery of payloads. Full article
(This article belongs to the Special Issue Advances in Nanoscale Materials in Biomedicine)
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19 pages, 4012 KiB  
Article
One-Shot Laser-Pulse Modification of Bare and Silica-Coated Gold Nanoparticles of Various Morphologies
by Vitaly A. Khanadeev, Andrey V. Simonenko, Oleg V. Grishin and Nikolai G. Khlebtsov
Nanomaterials 2023, 13(8), 1312; https://doi.org/10.3390/nano13081312 - 08 Apr 2023
Cited by 2 | Viewed by 1292
Abstract
Gold nanoparticles are widely used in laser biomedical applications due to their favorable properties, mainly localized plasmon resonance. However, laser radiation can cause a change in the shape and size of plasmonic nanoparticles, thus resulting in an unwanted reduction of their photothermal and [...] Read more.
Gold nanoparticles are widely used in laser biomedical applications due to their favorable properties, mainly localized plasmon resonance. However, laser radiation can cause a change in the shape and size of plasmonic nanoparticles, thus resulting in an unwanted reduction of their photothermal and photodynamic efficiency due to a drastic alteration of optical properties. Most previously reported experiments were carried out with bulk colloids where different particles were irradiated by different numbers of laser pulses, thus making it difficult to accurately evaluate the laser power photomodification (PM) threshold. Here, we examine the one-shot nanosecond laser-pulse PM of bare and silica-coated gold nanoparticles moving in a capillary flow. Four types of gold nanoparticles, including nanostars, nanoantennas, nanorods, and SiO2@Au nanoshells, were fabricated for PM experiments. To evaluate the changes in the particle morphology under laser irradiation, we combine measurements of extinction spectra with electron microscopy. A quantitative spectral approach is developed to characterize the laser power PM threshold in terms of normalized extinction parameters. The experimentally determined PM threshold increases in series were as follows: nanorods, nanoantennas, nanoshells, and nanostars. An important observation is that even a thin silica shell significantly increases the photostability of gold nanorods. The developed methods and reported findings can be useful for the optimal design of plasmonic particles and laser irradiation parameters in various biomedical applications of functionalized hybrid nanostructures. Full article
(This article belongs to the Special Issue Advances in Nanoscale Materials in Biomedicine)
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15 pages, 2939 KiB  
Article
One-Pot Synthesis of Silica-Coated Gold Nanostructures Loaded with Cyanine 5.5 for Cell Imaging by SERS Spectroscopy
by Aleksei N. Smirnov, Simar F. Aslanov, Denis V. Danilov, Olga Yu. Kurapova and Elena V. Solovyeva
Nanomaterials 2023, 13(7), 1267; https://doi.org/10.3390/nano13071267 - 03 Apr 2023
Cited by 3 | Viewed by 1792
Abstract
Anisotropic gold nanoparticles have been recognized as promising agents for medical diagnostics and cancer therapy due to their wide functionality, photothermal effect, and ability for optical signal amplification in the near-infrared range. In this work, a simple and rapid method for the preparation [...] Read more.
Anisotropic gold nanoparticles have been recognized as promising agents for medical diagnostics and cancer therapy due to their wide functionality, photothermal effect, and ability for optical signal amplification in the near-infrared range. In this work, a simple and rapid method for the preparation of bone-shaped gold nanoparticles coated with a dye-impregnated silica shell with an aminated surface is proposed. The possibility of further functionalization the nanostructures with a delivery vector using folic acid as an example is demonstrated. The average size of the resulting tags does not exceed 70 nm, meeting the criteria of cell endocytosis. The prepared tags exhibit surface-enhanced Raman scattering (SERS) spectra at excitation with lasers of 632.8 and 785 nm. Cell imaging is performed on HeLa cells based on the most pronounced SERS bands as a tracking signal. The obtained images, along with scanning electron microscopy of cell samples, revealed the tendency of tags to agglomerate during endocytosis followed by the “hot spots” effect. To evaluate the toxic and proliferative effect of the nanotags, an MTT assay was performed with two HeLa and HEP G2 cell lines. The results revealed higher viability for HEP G2 cells. Full article
(This article belongs to the Special Issue Advances in Nanoscale Materials in Biomedicine)
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14 pages, 2162 KiB  
Article
Chemical Modifications Influence the Number of siRNA Molecules Adsorbed on Gold Nanoparticles and the Efficiency of Downregulation of a Target Protein
by Anna V. Epanchintseva, Julia E. Poletaeva, Anton S. Dome, Ilya S. Dovydenko, Inna A. Pyshnaya and Elena I. Ryabchikova
Nanomaterials 2022, 12(24), 4450; https://doi.org/10.3390/nano12244450 - 14 Dec 2022
Cited by 2 | Viewed by 1121
Abstract
Small interfering RNAs (siRNAs) are a powerful tool for specific suppression of protein synthesis in the cell, and this determines the attractiveness of siRNAs as a drug. Low resistance of siRNA to nucleases and inability to enter into target cells are the most [...] Read more.
Small interfering RNAs (siRNAs) are a powerful tool for specific suppression of protein synthesis in the cell, and this determines the attractiveness of siRNAs as a drug. Low resistance of siRNA to nucleases and inability to enter into target cells are the most crucial issues in developing siRNA-based therapy. To face this challenge, we designed multilayer nanoconstruct (MLNC) with AuNP core bearing chemically modified siRNAs. We applied chemical modifications 2′-OMe and 2′-F substitutions as well as their combinations with phosphoryl guanidine group in the internucleotide phosphate. The effect of modification on the efficiency of siRNA loading into nanocarriers was examined. The introduction of the internucleotide modifications into at least one of the strands raised the efficiency of siRNA adsorption on the surface of gold core. We also tested the stability of modified siRNA adsorbed on gold core in the presence of serum. Based on loading efficiency and stability, MLNCs with the most siRNA effective cargo were selected, and they showed an increase in biological activity compared to control MLNCs. Our study demonstrated the effect of chemical modifications of siRNA on its binding to the AuNP-based carrier, which directly affects the efficiency of target protein expression inhibition. Full article
(This article belongs to the Special Issue Advances in Nanoscale Materials in Biomedicine)
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15 pages, 3685 KiB  
Article
Ion Lithography of Single Ions Irradiation for Spatially Regular Arrays of Pores in Membranes of Polyethylene Terephthalate
by Mariapompea Cutroneo, Vladimir Hnatowicz, Anna Mackova, Petr Malinsky, Romana Miksova, Giovanni Ceccio, Jan Maly, Jiří Smejkal, Marcel Štofik and Vladimir Havranek
Nanomaterials 2022, 12(22), 3927; https://doi.org/10.3390/nano12223927 - 08 Nov 2022
Cited by 5 | Viewed by 1119
Abstract
Routinely, in membrane technology, the decay from radioactive particles or the bombardment of ions with MeV energy per nucleon have been employed for the production of narrow and long pores in membranes. Presently, the ion lithography is proposed to make the fabrication cost [...] Read more.
Routinely, in membrane technology, the decay from radioactive particles or the bombardment of ions with MeV energy per nucleon have been employed for the production of narrow and long pores in membranes. Presently, the ion lithography is proposed to make the fabrication cost more affordable. It is prospective for the use of medium capacity accelerators making more feasible the fabrication of customized membranes. Thin polyethylene terephthalate foils have been patterned using 12 MeV O5+ ions and then processed to obtain good aspect ratio ion track pores in membranes. Pores of micrometric diameter with the following profiles were fabricated in the membranes: truncated cone, double conical, ideal cone, and cylindrical. Monitoring of the shape and size of pores has been attempted with a combination of Scanning Transmission Ion Microscope and a newly designed simulation program. This study is focused on the use of low-energy ions, accomplished in all laboratories, for the fabrication of membranes where the pores are not randomly traced and exhibit higher surface density and negligible overlapping than in membranes commonly manufactured. The good reproducibility and the ordered pore locations can be potentially utilized in applications such as microfluidics and organ-on-chip microsystems, where cells growing over porous substrates are used in simulation of biological barriers and transport processes. Full article
(This article belongs to the Special Issue Advances in Nanoscale Materials in Biomedicine)
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Review

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27 pages, 6098 KiB  
Review
Multifunctional Layered Double Hydroxides for Drug Delivery and Imaging
by Seungjin Yu, Goeun Choi and Jin-Ho Choy
Nanomaterials 2023, 13(6), 1102; https://doi.org/10.3390/nano13061102 - 19 Mar 2023
Cited by 9 | Viewed by 2964
Abstract
Two-dimensional nanomaterials, particularly layered double hydroxides (LDHs), have been widely applied in the biomedical field owing to their biocompatibility, biodegradability, controllable drug release/loading ability, and enhanced cellular permeability. Since the first study analyzing intercalative LDHs in 1999, numerous studies have investigated their biomedical [...] Read more.
Two-dimensional nanomaterials, particularly layered double hydroxides (LDHs), have been widely applied in the biomedical field owing to their biocompatibility, biodegradability, controllable drug release/loading ability, and enhanced cellular permeability. Since the first study analyzing intercalative LDHs in 1999, numerous studies have investigated their biomedical applications, including drug delivery and imaging; recent research has focused on the design and development of multifunctional LDHs. This review summarizes the synthetic strategies and in-vivo and in-vitro therapeutic actions and targeting properties of single-function LDH-based nanohybrids and recently reported (from 2019 to 2023) multifunctional systems developed for drug delivery and/or bio-imaging. Full article
(This article belongs to the Special Issue Advances in Nanoscale Materials in Biomedicine)
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