Antimicrobial Nano Coatings

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: closed (30 November 2022) | Viewed by 25042

Special Issue Editors


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Guest Editor
Institute of Molecular and Cell Biology, University of Tartu, Riia 23, 51010 Tartu, Estonia
Interests: antimicrobial materials and surfaces; efficacy testing of materials and surfaces; antibiotic resistance; safety testing of materials

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Guest Editor
Faculty of Technology and WANDER Nordic Water and Materials Institute, Satakunta University of Applied Sciences, 26101 Rauma, Finland
Interests: antimicrobial materials; surfaces; antimicrobial resistance; efficacy testing in real life settings

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Guest Editor
Institute of Pharmacy, Faculty of Medicine, University of Tartu, Nooruse 1, 50411 Tartu, Estonia
Interests: electrospinning; nanofibers/microfibers; antimicrobial drugs; delivery systems; wound healing; wound infection; antimicrobial agents; action mechanisms; in vitro/in vivo infection models; solid state characterization; process analytical technology
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Special Issue Information

Dear Colleagues,

You are cordially invited to submit your work on nanomaterial-based antimicrobial coatings and surfaces, including work on their preparation, characterization, and antimicrobial testing, to this Special Issue of Nanomaterials.

Surfaces are one of the most significant sources involved in the spread of microbial infections. The highest level of microbial transmission via surfaces occurs in healthcare, food preparation, and sanitary facilities but also in public space via frequently touched (i.e., high-touch) surfaces. Beside planktonic forms, microbial biofilms easily attach onto and colonize various surfaces. Considering the speed of transmission of microbes via surfaces, the fast elimination of contagious microbes from surfaces is key to combating microbial infections. Antimicrobial surfaces have already been used to reduce microbial pathogens on various surfaces. Silver- and copper-based microbicidal surfaces have the longest history and the widest use, but the popularity of nanomaterials and nanostructures in antimicrobial surfaces is on the rise.

This Special Issue aims to highlight current advances in the field of nanomaterial-based or nanostructured antimicrobial coatings and surfaces. We look forward to receiving your manuscripts reporting the preparation, characterization, and evaluation of antimicrobial activity, as well as mechanisms of action. Both research papers and review papers are more than welcome.

Prof. Angela Ivask
Dr. Merja Ahonen
Dr. Karin Kogermann
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antimicrobial surfaces
  • antimicrobial coatings
  • nanoparticles
  • nanomaterials
  • nanocoatings
  • biofilms
  • device-related infections
  • antimicrobial resistance

Published Papers (8 papers)

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Editorial

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4 pages, 577 KiB  
Editorial
Antimicrobial Nano Coatings
by Angela Ivask, Merja Ahonen and Karin Kogermann
Nanomaterials 2022, 12(23), 4338; https://doi.org/10.3390/nano12234338 - 06 Dec 2022
Viewed by 1104
Abstract
History has demonstrated that the uncontrolled fast thriving of potentially pathogenic microorganisms may lead to serious consequences and, thus, the approaches helping to control the microbial numbers in infectional hot-spots are necessary [...] Full article
(This article belongs to the Special Issue Antimicrobial Nano Coatings)
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Research

Jump to: Editorial

17 pages, 2237 KiB  
Article
Synthesis of ZnO/Au Nanocomposite for Antibacterial Applications
by Violeta Dediu, Mariana Busila, Vasilica Tucureanu, Florentina Ionela Bucur, Florina Silvia Iliescu, Oana Brincoveanu and Ciprian Iliescu
Nanomaterials 2022, 12(21), 3832; https://doi.org/10.3390/nano12213832 - 30 Oct 2022
Cited by 13 | Viewed by 2076
Abstract
Annually, antimicrobial-resistant infections-related mortality worldwide accelerates due to the increased use of antibiotics during the coronavirus pandemic and the antimicrobial resistance, which grows exponentially, and disproportionately to the current rate of development of new antibiotics. Nanoparticles can be an alternative to the current [...] Read more.
Annually, antimicrobial-resistant infections-related mortality worldwide accelerates due to the increased use of antibiotics during the coronavirus pandemic and the antimicrobial resistance, which grows exponentially, and disproportionately to the current rate of development of new antibiotics. Nanoparticles can be an alternative to the current therapeutic approach against multi-drug resistance microorganisms caused infections. The motivation behind this work was to find a superior antibacterial nanomaterial, which can be efficient, biocompatible, and stable in time. This study evaluated the antibacterial activity of ZnO-based nanomaterials with different morphologies, synthesized through the solvothermal method and further modified with Au nanoparticles through wet chemical reduction. The structure, crystallinity, and morphology of ZnO and ZnO/Au nanomaterials have been investigated with XRD, SEM, TEM, DLS, and FTIR spectroscopy. The antibacterial effect of unmodified ZnO and ZnO/Au nanomaterials against Escherichia coli and Staphylococcus aureus was investigated through disc diffusion and tetrazolium/formazan (TTC) assays. The results showed that the proposed nanomaterials exhibited significant antibacterial effects on the Gram-positive and Gram-negative bacteria. Furthermore, ZnO nanorods with diameters smaller than 50 nm showed better antibacterial activity than ZnO nanorods with larger dimensions. The antibacterial efficiency against Escherichia coli and Staphylococcus aureus improved considerably by adding 0.2% (w/w) Au to ZnO nanorods. The results indicated the new materials’ potential for antibacterial applications. Full article
(This article belongs to the Special Issue Antimicrobial Nano Coatings)
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18 pages, 3096 KiB  
Article
In Situ Transformation of Electrospun Nanofibers into Nanofiber-Reinforced Hydrogels
by Alma Martin, Jenny Natalie Nyman, Rikke Reinholdt, Jun Cai, Anna-Lena Schaedel, Mariena J. A. van der Plas, Martin Malmsten, Thomas Rades and Andrea Heinz
Nanomaterials 2022, 12(14), 2437; https://doi.org/10.3390/nano12142437 - 16 Jul 2022
Cited by 4 | Viewed by 2224
Abstract
Nanofiber-reinforced hydrogels have recently gained attention in biomedical engineering. Such three-dimensional scaffolds show the mechanical strength and toughness of fibers while benefiting from the cooling and absorbing properties of hydrogels as well as a large pore size, potentially aiding cell migration. While many [...] Read more.
Nanofiber-reinforced hydrogels have recently gained attention in biomedical engineering. Such three-dimensional scaffolds show the mechanical strength and toughness of fibers while benefiting from the cooling and absorbing properties of hydrogels as well as a large pore size, potentially aiding cell migration. While many of such systems are prepared by complicated processes where fibers are produced separately to later be embedded in a hydrogel, we here provide proof of concept for a one-step solution. In more detail, we produced core-shell nanofibers from the natural proteins zein and gelatin by coaxial electrospinning. Upon hydration, the nanofibers were capable of directly transforming into a nanofiber-reinforced hydrogel, where the nanofibrous structure was retained by the zein core, while the gelatin-based shell turned into a hydrogel matrix. Our nanofiber-hydrogel composite showed swelling to ~800% of its original volume and water uptake of up to ~2500% in weight. The physical integrity of the nanofiber-reinforced hydrogel was found to be significantly improved in comparison to a hydrogel system without nanofibers. Additionally, tetracycline hydrochloride was incorporated into the fibers as an antimicrobial agent, and antimicrobial activity against Staphylococcus aureus and Escherichia coli was confirmed. Full article
(This article belongs to the Special Issue Antimicrobial Nano Coatings)
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19 pages, 3617 KiB  
Article
Enhancement of Biofunctionalization by Loading Manuka Oil on TiO2 Nanotubes
by Seo-Young Kim, Yu-Kyoung Kim, Yong-Seok Jang and Min-Ho Lee
Nanomaterials 2022, 12(3), 569; https://doi.org/10.3390/nano12030569 - 07 Feb 2022
Cited by 4 | Viewed by 1788
Abstract
Metallic implants (mesh) for guided bone regeneration can result in foreign body reactions with surrounding tissues, infection, and inflammatory reactions caused by micro-organisms in the oral cavity after implantation. This study aimed to reduce the possibility of surgical failure caused by microbial infection [...] Read more.
Metallic implants (mesh) for guided bone regeneration can result in foreign body reactions with surrounding tissues, infection, and inflammatory reactions caused by micro-organisms in the oral cavity after implantation. This study aimed to reduce the possibility of surgical failure caused by microbial infection by loading antibacterial manuka oil in a biocompatible nanostructure surface on Ti and to induce stable bone regeneration in the bone defect. The manuka oil from New Zealand consisted of a rich β-triketone chemotype, leptospermone, which showed strong inhibitory effects against several bacteria, even at very low oil concentrations. The TiO2 nanotubular layer formed by anodization effectively enhanced the surface hydrophilicity, bioactivity, and fast initial bone regeneration. A concentration of manuka oil in the range of 0.02% to less than 1% can have a synergistic effect on antibacterial activity and excellent biocompatibility. A manuka oil coating (especially with a concentration of 0.5%) on the TiO2 nanotube layer can be expected not only to prevent stenosis of the connective tissue around the mesh and inflammation by microbial infection but also to be effective in stable and rapid bone regeneration. Full article
(This article belongs to the Special Issue Antimicrobial Nano Coatings)
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19 pages, 3496 KiB  
Article
Preparation and Characterization of Photocatalytically Active Antibacterial Surfaces Covered with Acrylic Matrix Embedded Nano-ZnO and Nano-ZnO/Ag
by Merilin Rosenberg, Meeri Visnapuu, Kristjan Saal, Dmytro Danilian, Rainer Pärna, Angela Ivask and Vambola Kisand
Nanomaterials 2021, 11(12), 3384; https://doi.org/10.3390/nano11123384 - 14 Dec 2021
Cited by 6 | Viewed by 2474
Abstract
In the context of healthcare-acquired infections, microbial cross-contamination and the spread of antibiotic resistance, additional passive measures to prevent pathogen carryover are urgently needed. Antimicrobial high-touch surfaces that kill microbes on contact or prevent their adhesion could be considered to mitigate the spread. [...] Read more.
In the context of healthcare-acquired infections, microbial cross-contamination and the spread of antibiotic resistance, additional passive measures to prevent pathogen carryover are urgently needed. Antimicrobial high-touch surfaces that kill microbes on contact or prevent their adhesion could be considered to mitigate the spread. Here, we demonstrate that photocatalytic nano-ZnO- and nano-ZnO/Ag-based antibacterial surfaces with efficacy of at least a 2.7-log reduction in Escherichia coli and Staphylococcus aureus viability in 2 h can be produced by simple measures using a commercial acrylic topcoat for wood surfaces. We characterize the surfaces taking into account cyclic wear and variable environmental conditions. The light-induced antibacterial and photocatalytic activities of the surfaces are enhanced by short-term cyclic wear, indicating their potential for prolonged effectivity in long-term use. As the produced surfaces are generally more effective at higher relative air humidity and silver-containing surfaces lost their contact-killing properties in dry conditions, it is important to critically evaluate the end-use conditions of materials and surfaces to be tested and select application-appropriate methods for their efficacy assessment. Full article
(This article belongs to the Special Issue Antimicrobial Nano Coatings)
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12 pages, 3178 KiB  
Article
Simultaneous Ultrasound-Assisted Hybrid Polyzwitterion/Antimicrobial Peptide Nanoparticles Synthesis and Deposition on Silicone Urinary Catheters for Prevention of Biofilm-Associated Infections
by Aleksandra Ivanova, Kristina Ivanova and Tzanko Tzanov
Nanomaterials 2021, 11(11), 3143; https://doi.org/10.3390/nano11113143 - 21 Nov 2021
Cited by 6 | Viewed by 2430
Abstract
Nosocomial infections caused by antibiotic-resistant bacteria are constantly growing healthcare threats, as they are the reason for the increased mortality, morbidity, and considerable financial burden due to the poor infection outcomes. Indwelling medical devices, such as urinary catheters, are frequently colonized by bacteria [...] Read more.
Nosocomial infections caused by antibiotic-resistant bacteria are constantly growing healthcare threats, as they are the reason for the increased mortality, morbidity, and considerable financial burden due to the poor infection outcomes. Indwelling medical devices, such as urinary catheters, are frequently colonized by bacteria in the form of biofilms that cause dysfunction of the device and severe chronic infections. The current treatment strategies of such device-associated infections are impaired by the resistant pathogens but also by a risk of prompting the appearance of new antibiotic-resistant bacterial mechanisms. Herein, the one-step sonochemical synthesis of hybrid poly(sulfobetaine) methacrylate/Polymyxin B nanoparticles (pSBMA@PM NPs) coating was employed to engineer novel nanoenabled silicone catheters with improved antifouling, antibacterial, and antibiofilm efficiencies. The synergistic mode of action of nanohybridized zwitterionic polymer and antimicrobial peptide led to complete inhibition of the nonspecific protein adsorption and up to 97% reduction in Pseudomonas aeruginosa biofilm formation, in comparison with the pristine silicone. Additionally, the bactericidal activity in the hybrid coating reduced the free-floating and surface-attached bacterial growth by 8 logs, minimizing the probability for further P. aeruginosa spreading and host invasion. This coating was stable for up to 7 days under conditions simulating the real scenario of catheter usage and inhibited by 80% P. aeruginosa biofilms. For the same time of use, the pSBMA@PM NPs coating did not affect the metabolic activity and morphology of mammalian cells, demonstrating their capacity to control antibiotic-resistant biofilm-associated bacterial infections. Full article
(This article belongs to the Special Issue Antimicrobial Nano Coatings)
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17 pages, 2433 KiB  
Article
Chelidoniummajus L. Incorporated Emulsion Electrospun PCL/PVA_PEC Nanofibrous Meshes for Antibacterial Wound Dressing Applications
by Cláudia Mouro, Ana P. Gomes, Merja Ahonen, Raul Fangueiro and Isabel C. Gouveia
Nanomaterials 2021, 11(7), 1785; https://doi.org/10.3390/nano11071785 - 09 Jul 2021
Cited by 32 | Viewed by 2950
Abstract
Presently, there are many different types of wound dressings available on the market. Nonetheless, there is still a great interest to improve the performance and efficiency of these materials. Concerning that, new dressing materials containing natural products, such as medicinal plants that protect [...] Read more.
Presently, there are many different types of wound dressings available on the market. Nonetheless, there is still a great interest to improve the performance and efficiency of these materials. Concerning that, new dressing materials containing natural products, such as medicinal plants that protect the wound from infections but also enhance skin regeneration have been or are being developed. Herein, we used for the first time a needleless emulsion electrospinning technique for incorporating Chelidoniummajus L. (C. majus), a medicinal plant widely known for its traditional therapeutic properties, in Polycaprolactone (PCL)/Polyvinyl Alcohol (PVA)_Pectin (PEC) nanofibrous meshes. Moreover, the potential use of these electrospun nanofibers as a carrier for C. majus was also explored. The results obtained revealed that the produced PCL/PVA_PEC nanofibrous meshes containing C. majus extract displayed morphological characteristics similar to the natural extracellular matrix of the skin (ECM). Furthermore, the produced meshes showed beneficial properties to support the healing process. Additionally, the C. majus-loaded PCL/PVA_PEC nanofibrous meshes inhibited Staphylococcus aureus (S. aureus) and Pseudomonas aeruginosa (P. aeruginosa) growth, reaching a 3.82 Log reduction, and showed to be useful for controlled release, without causing any cytotoxic effect on the normal human dermal fibroblasts (NHDF) cells. Hence, these findings suggest the promising suitability of this novel wound dressing material for prevention and treatment of bacterial wound infections. Full article
(This article belongs to the Special Issue Antimicrobial Nano Coatings)
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9 pages, 1501 KiB  
Article
Antiviral Activity of Silver, Copper Oxide and Zinc Oxide Nanoparticle Coatings against SARS-CoV-2
by Padryk Merkl, Siwen Long, Gerald M. McInerney and Georgios A. Sotiriou
Nanomaterials 2021, 11(5), 1312; https://doi.org/10.3390/nano11051312 - 17 May 2021
Cited by 95 | Viewed by 8402
Abstract
SARS-CoV-2 is responsible for several million deaths to date globally, and both fomite transmission from surfaces as well as airborne transmission from aerosols may be largely responsible for the spread of the virus. Here, nanoparticle coatings of three antimicrobial materials (Ag, CuO and [...] Read more.
SARS-CoV-2 is responsible for several million deaths to date globally, and both fomite transmission from surfaces as well as airborne transmission from aerosols may be largely responsible for the spread of the virus. Here, nanoparticle coatings of three antimicrobial materials (Ag, CuO and ZnO) are deposited on both solid flat surfaces as well as porous filter media, and their activity against SARS-CoV-2 viability is compared with a viral plaque assay. These nanocoatings are manufactured by aerosol nanoparticle self-assembly during their flame synthesis. Nanosilver particles as a coating exhibit the strongest antiviral activity of the three studied nanomaterials, while copper oxide exhibits moderate activity, and zinc oxide does not appear to significantly reduce the virus infectivity. Thus, nanosilver and copper oxide show potential as antiviral coatings on solid surfaces and on filter media to minimize transmission and super-spreading events while also providing critical information for the current and any future pandemic mitigation efforts. Full article
(This article belongs to the Special Issue Antimicrobial Nano Coatings)
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