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Special Issue "Prospects of Bioinspired and Biomimetic Materials"

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A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: closed (10 April 2023) | Viewed by 12258

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Dr. Touseef Amna

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Department of Biology, College of Science, Albaha University, P.O. Box 1988, Albaha 65799, Saudi Arabia
Interests: design and synthesis of biocompatible composite nanofibrous scaffolds via electrospinning processes; synthesis of hybrid materials, biomimetic materials and nanoparticles; physicochemical characterization of biomaterials or materials; diverse biological applications such as cell culture, tissue engineering and biomedical and antimicrobial synthesized materials
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Dr. M. Shamshi Hassan
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Department of Chemistry, Albaha University, Albaha, Saudi Arabia
Interests: nanobiotechnology

Special Issue Information

Dear Colleagues,

Bioinspired materials are human-made imitations resembling innate matter in characteristics, organization and purpose. In other words, biomaterial can be engineered to acquire the outline of an entire system or of the component of a system and interact with a living system during a therapeutic and diagnostic process. Representative examples of bioinspired materials are photonic materials mimicking photosynthesis, composites mimicking nacre, etc. This Special Issue focuses on a variety of physical, biological and chemical disciplines which support the synthesis of bioinspired composites or biocomposites, as well their applications. Some of the fields to be covered are synthesis and characterization of biomaterials, nanofibers, nanocomposites, nanoparticles, tissue engineering, antimicrobial activities, biomedical screening and toxicology evaluation of biofabricated materials.

This Special Issue aims to cover the state of the art of biomimetic materials that pursue a planned pattern derivative of the natural world.

The Special Issue is to provide a peer-reviewed forum for the publication of original papers, review articles, opinion papers and short communications. The scope of this Special Issue aims to cover biomedical and toxicology aspects of biofabricated materials. We welcome contributions on the following topics:

Design and synthesis of bionanocomposites.
Synthesis of hybrid materials using various procedures.
Detailed physicochemical characterization of biomaterials and materials.
Diverse biological applications such as cell culture, tissue engineering, biomedical and antimicrobial screening of synthesized materials.
Applications of bioinspired materials in bioremediation.

Prof. Dr. Touseef Amna
Dr. M. Shamshi Hassan
Guest Editor

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Keywords

Nanocomposites
Nanofibers
Biomimetic materials
Tissue engineering
Antimicrobial
Bioremediation
Biomedical
Biofabrication
Characterization

Published Papers (9 papers)

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Research

Open AccessArticle

Green Nanoformulations of Polyvinylpyrrolidone-Capped Metal Nanoparticles: A Study at the Hybrid Interface with Biomimetic Cell Membranes and In Vitro Cell Models

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Nanomaterials 2023, 13(10), 1624; https://doi.org/10.3390/nano13101624 - 12 May 2023

Viewed by 458

Abstract

Noble metal nanoparticles (NP) with intrinsic antiangiogenic, antibacterial, and anti-inflammatory properties have great potential as potent chemotherapeutics, due to their unique features, including plasmonic properties for application in photothermal therapy, and their capability to slow down the migration/invasion speed of cancer cells and then suppress metastasis. In this work, gold (Au), silver (Ag), and palladium (Pd) NP were synthesized by a green redox chemistry method with the reduction of the metal salt precursor with glucose in the presence of polyvinylpyrrolidone (PVP) as stabilizing and capping agent. The physicochemical properties of the PVP-capped NP were investigated by UV-visible (UV-vis) and attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopies, dynamic light scattering (DLS), and atomic force microscopy (AFM), to scrutinize the optical features and the interface between the metal surface and the capping polymer, the hydrodynamic size, and the morphology, respectively. Biophysical studies with model cell membranes were carried out by using laser scanning confocal microscopy (LSM) with fluorescence recovery after photobleaching (FRAP) and fluorescence resonance energy transfer (FRET) techniques. To this purpose, artificial cell membranes of supported lipid bilayers (SLBs) made with 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (POPC) dye-labeled with 7-nitro-2-1,3-benzoxadiazol-4-yl (NBD, FRET donor) and/or lissamine rhodamine B sulfonyl (Rh, FRET acceptor) were prepared. Proof-of-work in vitro cellular experiments were carried out with prostate cancer cells (PC-3 line) in terms of cytotoxicity, cell migration (wound scratch assay), NP cellular uptake, and cytoskeleton actin perturbation. Full article

(This article belongs to the Special Issue Prospects of Bioinspired and Biomimetic Materials)

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Open AccessArticle

Nanotextured CeO₂−SnO₂ Composite: Efficient Photocatalytic, Antibacterial, and Energy Storage Fibers

Mohsen A. M. Alhamami

Amal F. Seliem

M. Faisal

and

H. Y. Kim

Nanomaterials 2023, 13(6), 1001; https://doi.org/10.3390/nano13061001 - 10 Mar 2023

Cited by 1 | Viewed by 794

Abstract

Bacterial infections remain a serious and pervasive threat to human health. Bacterial antibiotic resistance, in particular, lowers treatment efficacy and increases mortality. The development of nanomaterials has made it possible to address issues in the biomedical, energy storage, and environmental fields. This paper reports the successful synthesis of CeO₂−SnO₂ composite nanofibers via an electrospinning method using polyacrylonitrile polymer. Scanning and transmission electron microscopy assessments showed that the average diameter of CeO₂−SnO₂ nanofibers was 170 nm. The result of photocatalytic degradation for methylene blue dye displayed enhanced efficiency of the CeO₂−SnO₂ composite. The addition of SnO₂ to CeO₂ resulted in the enhancement of the light absorption property and enriched charge transmission of photoinduced electron–hole duos, which conspicuously contributed to momentous photoactivity augmentation. Composite nanofibers exhibited higher specific capacitance which may be accredited to the synergism between CeO₂ and SnO₂ particles in nanofibers. Furthermore, antibacterial activity was screened against Escherichia coli and CeO₂−SnO₂ composite nanofibers depicted excellent activity. The findings of this work point to new possibilities as an electrode material in energy storage systems and as a visible-light-active photocatalyst for the purification of chemical and biological contaminants, which would substantially benefit environmental remediation processes. Full article

(This article belongs to the Special Issue Prospects of Bioinspired and Biomimetic Materials)

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Open AccessArticle

Chitosan-Functionalized Hydroxyapatite-Cerium Oxide Heterostructure: An Efficient Adsorbent for Dyes Removal and Antimicrobial Agent

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Nanomaterials 2022, 12(15), 2713; https://doi.org/10.3390/nano12152713 - 07 Aug 2022

Cited by 8 | Viewed by 1134

Abstract

The current research intended to employ a facile and economical process, which is also ecofriendly to transform camel waste bones into novel heterostructure for cleansing of diverse waste waters. The bones of camel were utilized for preparation of hydroxyapatite by hydrothermal method. The prepared hydroxyapatite was applied to the synthesis of cerium oxide-hydroxyapatite coated with natural polymer chitosan (CS-HAP-CeO₂) heterostructure. Being abundant natural polymer polysaccharide, chitosan possesses exceptional assets such as accessibility, economic price, hydrophilicity, biocompatibility as well as biodegradability, therefore style it as an outstanding adsorbent for removing colorant and other waste molecules form water. This heterostructure was characterized by various physicochemical processes such as XRD, SEM-EDX, TEM, and FT-IR. The CS-HAP-CeO₂ was screened for adsorption of various industrially important dyes, viz., Brilliant blue (BB), Congo red (CR), Crystal violet (CV), Methylene blue (MB), Methyl orange (MO), and Rhodamine B (RB) which are collective pollutants of industrial waste waters. The CS-HAP-CeO₂ demonstrated exceptional adsorption against CR dye. The adsorption/or removal efficiency ranges are BB (11.22%), CR (96%), CV (28.22%), MB (47.74%), MO (2.43%), and RB (58.89%) dyes. Moreover, this heterostructure showed excellent bacteriostatic potential for E. coli, that is liable for serious waterborne diseases. Interestingly, this work revealed that the incorporation of cerium oxide and chitosan into hydroxyapatite substantially strengthened antimicrobial and adsorption capabilities than those observed in virgin hydroxyapatite. Herein, we recycled the unwanted camel bones into a novel heterostructure, which assists to reduce water pollution, mainly caused by the dye industries. Full article

(This article belongs to the Special Issue Prospects of Bioinspired and Biomimetic Materials)

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Open AccessEditor’s ChoiceArticle

Bactericidal and Antiviral Bionic Metalized Nanocoatings

Mikhail Kryuchkov

Jozef Adamcik

and

Vladimir L. Katanaev

Nanomaterials 2022, 12(11), 1868; https://doi.org/10.3390/nano12111868 - 30 May 2022

Cited by 2 | Viewed by 1439

Abstract

In diverse living organisms, bionanocoatings provide multiple functionalities, to the surfaces they cover. We have, previously, identified the molecular mechanisms of Turing-based self-assembly of insect corneal nanocoatings and developed forward-engineering approaches to construct multifunctional soft bionic nanocoatings, encompassing the Drosophila protein Retinin. Here, we expand the versatility of the bionic nanocoatings, by identifying and using diverse Retinin-like proteins and different methods of their metallization, using nickel, silver, and copper ions. Comparative assessment, of the resulting bactericidal, antiviral, and cytotoxic properties, identifies the best protocols, to construct safe and anti-infective metalized bionic nanocoatings. Upscaled application of these protocols, to various public surfaces, may represent a safe and economic approach to limit hazardous infections. Full article

(This article belongs to the Special Issue Prospects of Bioinspired and Biomimetic Materials)

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Open AccessArticle

Manganese Ferrite–Hydroxyapatite Nanocomposite Synthesis: Biogenic Waste Remodeling for Water Decontamination

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Nanomaterials 2022, 12(10), 1631; https://doi.org/10.3390/nano12101631 - 11 May 2022

Cited by 4 | Viewed by 1460

Abstract

Environmental pollution, especially water pollution caused by dyes, heavy metal ions and biological pathogens, is a root cause of various lethal diseases in human-beings and animals. Water purification materials and treatment methods are overpriced. Consequently, there is an imperative outlook observance for cheap materials for the purification of wastewaters. In order to fill up the projected demand for clean water, the present study aimed to make use of cost-effective and environmentally friendly methods to convert bone-waste from animals such as cows into novel composites for the decontamination of water. The bone-waste of slaughtered cows from the Najran region of Saudi Arabia was collected and used for the synthesis of hydroxyapatite based on the thermal method. The synthesized hydroxyapatite (Ca₁₀(PO₄)₆(OH)₂) was utilized to prepare a manganese ferrite/hydroxyapatite composite. The nanocomposite was categorized by diverse sophisticated procedures, for instance XRD, FE-SEM, EDX, TEM, UV, PL and FT-IR. This composite possesses outstanding photocatalytic activity against methylene blue dye, which is a common pollutant from industrial wastes. Moreover, the synthesised composite revealed exceptional bacteriostatic commotion towards E. coli and S. aureus bacteria, which are accountable for acute waterborne infections. The outcome of this study demonstrated that the integration of manganese ferrite into hydroxyapatite significantly intensified both antimicrobial and photocatalytic actions when compared to the virgin hydroxyapatite. Full article

(This article belongs to the Special Issue Prospects of Bioinspired and Biomimetic Materials)

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Open AccessArticle

ZnO Nanocomposites of Juniperus procera and Dodonaea viscosa Extracts as Antiproliferative and Antimicrobial Agents

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Nanomaterials 2022, 12(4), 664; https://doi.org/10.3390/nano12040664 - 16 Feb 2022

Cited by 5 | Viewed by 1459

Abstract

Cancer and microbial infections constitute a major burden and leading cause of death globally. The development of therapeutic compounds from natural products is considered a cornerstone in drug discovery. Therefore, in the present study, the ethanolic extract and the fractions of Dodonaea viscosa and Juniperus procera were evaluated for anticancer and antimicrobial activities. It was found that two fractions, JM and DC, exhibited promising anticancer and antimicrobial activities. The JM and DC fractions were further modified into ZnO nanocomposites, which were characterized by SEM, XRD, TGA, and EDX. It was noted that the synthesized nanocomposites displayed remarkable enhancement in cytotoxicity as well as antibacterial activity. Nanocomposite DC–ZnO NRs exhibited cytotoxicity with IC₅₀ values of 16.4 ± 4 (HepG2) and 29.07 ± 2.7 μg/mL (HCT-116) and JM–ZnO NRs with IC₅₀ values of 12.2 ± 10.27 (HepG2) and 24.1 ± 3.0 μg/mL (HCT-116). In addition, nanocomposites of DC (i.e., DC–ZnO NRs) and JM (i.e., JM–ZnO NRs) displayed excellent antimicrobial activity against Staphylococcus aureus with MICs of 2.5 and 1.25 μg/mL, respectively. Moreover, these fractions and nanocomposites were tested for cytotoxicity against normal fibroblasts and were found to be non-toxic. GC-MS analysis of the active fractions were also carried out to discover the possible phytochemicals that are responsible for these activities. Full article

(This article belongs to the Special Issue Prospects of Bioinspired and Biomimetic Materials)

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Open AccessFeature PaperArticle

Successful Dendrimer and Liposome-Based Strategies to Solubilize an Antiproliferative Pyrazole Otherwise Not Clinically Applicable

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Nanomaterials 2022, 12(2), 233; https://doi.org/10.3390/nano12020233 - 11 Jan 2022

Cited by 14 | Viewed by 1298

Abstract

Water-soluble formulations of the pyrazole derivative 3-(4-chlorophenyl)-5-(4-nitrophenylamino)-1H-pyrazole-4-carbonitrile (CR232), which were proven to have in vitro antiproliferative effects on different cancer cell lines, were prepared by two diverse nanotechnological approaches. Importantly, without using harmful organic solvents or additives potentially toxic to humans, CR232 was firstly entrapped in a biodegradable fifth-generation dendrimer containing lysine (G5K). CR232-G5K nanoparticles (CR232-G5K NPs) were obtained with high loading (DL%) and encapsulation efficiency (EE%), which showed a complex but quantitative release profile governed by Weibull kinetics. Secondly, starting from hydrogenated soy phosphatidylcholine and cholesterol, we prepared biocompatible CR232-loaded liposomes (CR232-SUVs), which displayed DL% and EE% values increasing with the increase in the lipids/CR232 ratio initially adopted and showed a constant prolonged release profile ruled by zero-order kinetics. When relevant, attenuated total reflectance Fourier transformed infrared spectroscopy (ATR-FTIR) and nuclear magnetic resonance (NMR) spectroscopy, scanning electron microscopy (SEM) and dynamic light scattering (DLS) experiments, as well as potentiometric titrations completed the characterization of the prepared NPs. CR232-G5K NPs were 2311-fold more water-soluble than the pristine CR232, and the CR232-SUVs with the highest DL% were 1764-fold more soluble than the untreated CR232, thus establishing the success of both our strategies. Full article

(This article belongs to the Special Issue Prospects of Bioinspired and Biomimetic Materials)

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Open AccessArticle

Biocompatibility Computation of Muscle Cells on Polyhedral Oligomeric Silsesquioxane-Grafted Polyurethane Nanomatrix

Touseef Amna

Mallick Shamshi Hassan

Mohamed H. El-Newehy

Tariq Alghamdi

Meera Moydeen Abdulhameed

and

Myung-Seob Khil

Nanomaterials 2021, 11(11), 2966; https://doi.org/10.3390/nano11112966 - 05 Nov 2021

Cited by 6 | Viewed by 1245

Abstract

This study was performed to appraise the biocompatibility of polyhedral oligomeric silsesquioxane (POSS)-grafted polyurethane (PU) nanocomposites as potential materials for muscle tissue renewal. POSS nanoparticles demonstrate effectual nucleation and cause noteworthy enhancement in mechanical and thermal steadiness as well as biocompatibility of resultant composites. Electrospun, well-aligned, POSS-grafted PU nanofibers were prepared. Physicochemical investigation was conducted using several experimental techniques, including scanning electron microscopy, energy dispersive X-ray spectroscopy, electron probe microanalysis, Fourier transform infrared spectroscopy, and X-ray diffraction pattern. Adding POSS molecules to PU did not influence the processability and morphology of the nanocomposite; however, we observed an obvious mean reduction in fiber diameter, which amplified specific areas of the POSS-grafted PU. Prospective biomedical uses of nanocomposite were also appraised for myoblast cell differentiation in vitro. Little is known about C2C12 cellular responses to PU, and there is no information regarding their interaction with POSS-grafted PU. The antimicrobial potential, anchorage, proliferation, communication, and differentiation of C2C12 on PU and POSS-grafted PU were investigated in this study. In conclusion, preliminary nanocomposites depicted superior cell adhesion due to the elevated free energy of POSS molecules and anti-inflammatory potential. These nanofibers were non-hazardous, and, as such, biomimetic scaffolds show high potential for cellular studies and muscle regeneration. Full article

(This article belongs to the Special Issue Prospects of Bioinspired and Biomimetic Materials)

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Open AccessArticle

Natural Clay as a Low-Cost Adsorbent for Crystal Violet Dye Removal and Antimicrobial Activity

Ali Q. Alorabi

Mallick Shamshi Hassan

Mohammad Mahboob Alam

Sami A. Zabin

Nawaf I. Alsenani

and

Neazar Essam Baghdadi

Nanomaterials 2021, 11(11), 2789; https://doi.org/10.3390/nano11112789 - 21 Oct 2021

Cited by 20 | Viewed by 1706

Abstract

This investigation aimed at evaluating the efficiency of micro and nanoclays as a low-cost material for the removal of crystal violet (CV) dye from an aqueous solution. The impacts of various factors (contact time, pH, adsorbent dosage, temperature, initial dye concentration) on the adsorption process have been taken into consideration. Six micro and nanoclay samples were obtained by treating clay materials collected from different locations in the Albaha region, Saudi Arabia. Out of the six tested micro and nanoclays materials, two (NCQ1 and NCQ3) were selected based on the highest adsorption efficiency for complete experimentation. The morphology and structure of the selected micro and nanoclay adsorbents were characterized by various techniques: SEM-EDX, FTIR, XRF, XRD, and ICP-MS. The XRF showed that the main oxides of both nanoclays were SiO₂, Al₂O₃, Fe₂O₃, K₂O, CaO, and MgO, and the rest were impurities. All the parameters affecting the adsorption of CV dye were optimized in a batch system, and the optimized working conditions were an equilibrium time of 120 min, a dose of 30 mg, a temperature of 25 °C, and an initial CV concentration of 400 mg/L. The equilibrium data were tested using nonlinear isotherm and kinetic models, which showed that the Freundlich isotherm and pseudo-second-order kinetics gave the best fit with the experimental data, indicating a physico-chemical interaction occurred between the CV dye and both selected micro and nanoclay surfaces. The maximum adsorption capacities of NCQ1 and NCQ3 adsorbents were 206.73 and 203.66 mg/g, respectively, at 25 °C. The thermodynamic factors revealed that the CV dye adsorption of both micro and nanoclays was spontaneous and showed an exothermic process. Therefore, the examined natural micro and nanoclays adsorbents are promising effective adsorbents for the elimination of CV dye from an aqueous environment. Full article

(This article belongs to the Special Issue Prospects of Bioinspired and Biomimetic Materials)

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