Nanomaterials for Bioapplications: Chemical Stability and Biosafety

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 949

Special Issue Editors

Department of Biology, CESAM—Centre for Environmental and Marine Studies, University of Aveiro, 3810-193 Aveiro, Portugal
Interests: cytotoxicity; genotoxicity; nanoparticles for biological applications; nanotoxicity; drug delivery
Special Issues, Collections and Topics in MDPI journals
Centre for Environmental and Marine Studies, Department of Biology, University of Aveiro, 3810-193 Aveiro, Portugal
Interests: in vitro cell culture; cytotoxicity; genotoxicity; cancer therapy; nanobiomedicine; nanotoxicology; human health; environmental toxicology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Engineered nanomaterials are being investigated due to their increasing biological applications, including drug and gene delivery, biosensors, cancer treatment, and diagnostic tools. In this context, the stability and biosafety of nanomaterials are important aspects that need to be monitored for their successful biomedical application. Nanoparticles interact with biologic systems leading to their distribution, elimination, metabolism, and aggregation. Therefore, the stability of the nanoparticles is also a main topic of concern in their bioapplications.

The present Special Issue of Nanomaterials aims to present the current state-of-the-art developments of the use of nanomaterial for biomedical applications including therapy (e.g., drug delivery, gene delivery, phototherapies, and immunotherapy), imaging, diagnosis, theranostics, biosensing, and tissue engineering. The relationship between nanoparticle stability and physical/chemical properties will be discussed, as will the mechanisms of promoting nanoparticle stability. Moreover, we also expect to provide new insights into the understanding of the contribution of surface chemistry to the stability, dissolution behavior, cytotoxicity, biodistribution, and biodegradation.

We invite authors to contribute original research articles, reviews, and short communications covering current progress in the use of nanomaterials for bioapplications.

Dr. Helena Oliveira
Dr. Verónica Bastos
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • inorganic and organic nanoparticles
  • synthesis of nanomaterials
  • functionalization and surface modification
  • thermal therapies
  • phototherapies
  • biomedical applications
  • hybrid nanomaterials
  • multifunctional nanoparticles
  • targeted nanomaterials as delivery systems

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:


13 pages, 3580 KiB  
A New Promising Material for Biological Applications: Multilevel Physical Modification of AgNP-Decorated PEEK
Nanomaterials 2023, 13(24), 3079; - 05 Dec 2023
Viewed by 685
In the case of polymer medical devices, the surface design plays a crucial role in the contact with human tissue. The use of AgNPs as antibacterial agents is well known; however, there is still more to be investigated about their anchoring into the [...] Read more.
In the case of polymer medical devices, the surface design plays a crucial role in the contact with human tissue. The use of AgNPs as antibacterial agents is well known; however, there is still more to be investigated about their anchoring into the polymer surface. This study describes the changes in the surface morphology and behaviour in the biological environment of polyetheretherketone (PEEK) with immobilised AgNPs after different surface modifications. The initial composites were prepared by immobilising silver nanoparticles from a colloid solution in the upper surface layers of polyetheretherketone (PEEK). The prepared samples (Ag/PEEK) had a planar morphology and were further modified with a KrF laser, a GaN laser, and an Ar plasma. The samples were studied using the AFM method to visualise changes in surface morphology and obtain information on the height of the structures and other surface parameters. A comparative analysis of the nanoparticles and polymers was performed using FEG-SEM. The chemical composition of the surface of the samples and optical activity were studied using XPS and UV-Vis spectroscopy. Finally, drop plate antibacterial and cytotoxicity tests were performed to determine the role of Ag nanoparticles after modification and suitability of the surface, which are important for the use of the resulting composite in biomedical applications. Full article
(This article belongs to the Special Issue Nanomaterials for Bioapplications: Chemical Stability and Biosafety)
Show Figures

Figure 1

Back to TopTop