Advances in Pharmaceutical Applications of Lipid-Based Nanoparticles

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: 31 March 2024 | Viewed by 1853

Special Issue Editor

CNRS UMR 8612 "Institut Galien Paris-Saclay", Paris-Saclay University, F-91400 Orsay, France
Interests: lipid/protein nanoassemblies; liquid crystalline phases; cubosomes; self-assembled nanostructures and nanoparticles with neuroprotective properties; nanomedicine; nanocarriers for macromolecular drug delivery; membrane receptor nanoscale organization; lipids; peptides; proteins; BDNF; cyclodextrin; soft nanomaterials
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Special Issue Information

Dear Colleagues,

Lipid-based nanomaterials and nanoparticles have gained considerable interest in vaccine development, targeted drug delivery, diagnostic imaging, and nanomedicine. They offer possibilities for the encapsulation of both hydrophilic and hydrophobic bioactive guest molecules in nanoscale reservoirs for controlled drug release. Lipid-based nanoparticles represent safe systems for the nanoformulation of mRNA, antimicrobial peptides, protein drugs, anti-viral, anti-inflammatory and anticancer agents, as well as for the delivery of nonviral gene-editing CRISPR-Cas9 complexes.

This Special Issue of Nanomaterials will focus on recent advances and ongoing cutting-edge research in the development of lipid nanoparticles (LNPs), liquid crystalline nanocarriers (cubosomes, spongosomes, hexosomes, and liposomes), nanostructured lipid carriers, solid lipid nanoparticles, and lipid–drug conjugates for potential new applications. The uses of LNPs and lipid-based nanomaterials as mono- and multidrug sustained delivery systems and their therapeutic uses in anti-viral therapies, cardioprotection, regenerative nanomedicine, slowing down of neurodegenerative disorders, and treatment of cancer, inflammation and infection diseases will be highlighted, among other possible applications. The preclinical and clinical status and the future prospects for lipid nanoparticle uses in diagnostics imaging, topical, intranasal, oral, and parenteral drug delivery as well as brain targeting will be considered. Remarkable attention will be given to the role of nanoparticle architectures and surface modifications in their cellular uptake mechanism.

Dr. Angelina Angelova
Guest Editor

Manuscript Submission Information

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Keywords

  • lipid nanoparticles (LNPs)
  • liposomes
  • liquid crystalline nanocarriers
  • nanostructured lipid carriers
  • anti-viral therapeutics
  • mRNA therapeutics
  • siRNA therapeutics
  • protein therapeutics
  • peptide therapeutics
  • CRISPR-Cas9 delivery
  • controlled drug release
  • drug–lipid conjugates
  • lipids in therapy
  • intranasal delivery

Published Papers (1 paper)

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Review

30 pages, 10706 KiB  
Review
Recent Uses of Lipid Nanoparticles, Cell-Penetrating and Bioactive Peptides for the Development of Brain-Targeted Nanomedicines against Neurodegenerative Disorders
by Yu Wu and Angelina Angelova
Nanomaterials 2023, 13(23), 3004; https://doi.org/10.3390/nano13233004 - 23 Nov 2023
Cited by 1 | Viewed by 1476
Abstract
The lack of effective treatments for neurodegenerative diseases (NDs) is an important current concern. Lipid nanoparticles can deliver innovative combinations of active molecules to target the various mechanisms of neurodegeneration. A significant challenge in delivering drugs to the brain for ND treatment is [...] Read more.
The lack of effective treatments for neurodegenerative diseases (NDs) is an important current concern. Lipid nanoparticles can deliver innovative combinations of active molecules to target the various mechanisms of neurodegeneration. A significant challenge in delivering drugs to the brain for ND treatment is associated with the blood–brain barrier, which limits the effectiveness of conventional drug administration. Current strategies utilizing lipid nanoparticles and cell-penetrating peptides, characterized by various uptake mechanisms, have the potential to extend the residence time and bioavailability of encapsulated drugs. Additionally, bioactive molecules with neurotropic or neuroprotective properties can be delivered to potentially mediate the ND targeting pathways, e.g., neurotrophin deficiency, impaired lipid metabolism, mitochondrial dysfunction, endoplasmic reticulum stress, accumulation of misfolded proteins or peptide fragments, toxic protein aggregates, oxidative stress damage, and neuroinflammation. This review discusses recent advancements in lipid nanoparticles and CPPs in view of the integration of these two approaches into nanomedicine development and dual-targeted nanoparticulate systems for brain delivery in neurodegenerative disorders. Full article
(This article belongs to the Special Issue Advances in Pharmaceutical Applications of Lipid-Based Nanoparticles)
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