Research

Jump to: Review

Open AccessArticle

Removal of Heavy Metal Ions from Aqueous Solution Using Biotransformed Lignite

by

,

,

,

,

,

and

Molecules 2023, 28(13), 5031; https://doi.org/10.3390/molecules28135031 - 27 Jun 2023

Viewed by 470

Abstract

Heavy metal pollution caused by industrial wastewater such as mining and metallurgical wastewater is a major global concern. Therefore, this study used modified lignite as a low-cost adsorbent for heavy metal ions. Pingzhuang lignite was dissolved and modified using Fusarium lignite B3 to [...] Read more.

Heavy metal pollution caused by industrial wastewater such as mining and metallurgical wastewater is a major global concern. Therefore, this study used modified lignite as a low-cost adsorbent for heavy metal ions. Pingzhuang lignite was dissolved and modified using Fusarium lignite B3 to prepare a biotransformed-lignite adsorbent (BLA). The O, H, and N contents of the BLA increased after transformation, and the specific surface area increased from 1.81 to 5.66 m²·g⁻¹. Various adsorption properties were investigated using an aqueous solution of Cu(Ⅱ). The kinetic and isothermal data were well-fitted by pseudo-second-order and Langmuir models, respectively. The Langmuir model showed that the theoretical Cu(II) adsorption capacity was 71.47 mg·g⁻¹. Moreover, large particles and a neutral pH were favorable for the adsorption of heavy metal ions. The adsorption capacities of raw lignite and BLA were compared for various ions. Microbial transformation greatly improved the adsorption capacity, and the BLA had good adsorption and passivation effects with Cu(II), Mn(II), Cd(II), and Hg(II). Investigation of the structural properties showed that the porosity and specific surface area increased after biotransformation, and there were more active groups such as –COOH, Ar–OH, and R–OH, which were involved in the adsorption performance. Full article

(This article belongs to the Special Issue Thermodynamics, Structure, and Intermolecular Interactions in Solutions)

► Show Figures

Figure 1

Open AccessArticle

Measurement and Correlation of Solubility of Thiamine Nitrate in Three Binary Solvents and Thermodynamic Properties for the Solutions in Different Binary Mixtures at (278.15–313.15) K

by

,

,

,

,

,

and

Molecules 2023, 28(13), 5012; https://doi.org/10.3390/molecules28135012 - 27 Jun 2023

Viewed by 442

Abstract

The solubility of thiamine nitrate in {(methanol, acetone, isopropanol) + water} solvents will provide essential support for crystallization design and further theoretical studies. In this study, the solubility was experimentally measured over temperatures ranging from 278.15 to 313.15 K under atmospheric pressure using [...] Read more.

The solubility of thiamine nitrate in {(methanol, acetone, isopropanol) + water} solvents will provide essential support for crystallization design and further theoretical studies. In this study, the solubility was experimentally measured over temperatures ranging from 278.15 to 313.15 K under atmospheric pressure using a dynamic method. The solubility increased with increasing temperature at a constant solvent composition. The dissolving capacity of thiamine nitrate in the three binary solvent mixtures at constant temperature in the low ratio of water ranked as water + methanol > water + acetone > water + isopropanol generally. Interestingly, in the high ratio of water systems, especially when the molar concentration of water was greater than 0.6, the dissolving capacity ranked as water + acetone > water + methanol > water + isopropanol. Additionally, the modified Apelblat equation, λh equation, van’t Hoff equation and NRTL model were used to correlate the solubility data in binary mixtures. It turned out that all the selected thermodynamic models could give satisfactory results. Furthermore, the thermodynamic properties of the dissolution process of thiamine nitrate were also calculated based on the modified van’t Hoff equation. The results indicate that the dissolution process of the thiamine nitrate in the selected solvents is all endothermic. Full article

(This article belongs to the Special Issue Thermodynamics, Structure, and Intermolecular Interactions in Solutions)

► Show Figures

Figure 1

Open AccessArticle

Eu(III) and Cm(III) Complexation by the Aminocarboxylates NTA, EDTA, and EGTA Studied with NMR, TRLFS, and ITC—An Improved Approach to More Robust Thermodynamics

by

,

,

,

,

,

,

and

Molecules 2023, 28(12), 4881; https://doi.org/10.3390/molecules28124881 - 20 Jun 2023

Viewed by 1117

Abstract

The complex formation of Eu(III) and Cm(III) was studied via tetradentate, hexadentate, and octadentate coordinating ligands of the aminopolycarboxylate family, viz., nitrilotriacetate (NTA³⁻), ethylenediaminetetraacetate (EDTA⁴⁻), and ethylene glycol-bis(2-aminoethyl ether)-N,N,N′,N′-tetraacetate (EGTA⁴⁻ [...] Read more.

The complex formation of Eu(III) and Cm(III) was studied via tetradentate, hexadentate, and octadentate coordinating ligands of the aminopolycarboxylate family, viz., nitrilotriacetate (NTA³⁻), ethylenediaminetetraacetate (EDTA⁴⁻), and ethylene glycol-bis(2-aminoethyl ether)-N,N,N′,N′-tetraacetate (EGTA⁴⁻), respectively. Based on the complexones’ pK_a values obtained from ¹H nuclear magnetic resonance (NMR) spectroscopic pH titration, complex formation constants were determined by means of the parallel-factor-analysis-assisted evaluation of Eu(III) and Cm(III) time-resolved laser-induced fluorescence spectroscopy (TRLFS). This was complemented by isothermal titration calorimetry (ITC), providing the enthalpy and entropy of the complex formation. This allowed us to obtain genuine species along with their molecular structures and corresponding reliable thermodynamic data. The three investigated complexones formed 1:1 complexes with both Eu(III) and Cm(III). Besides the established Eu(III)–NTA 1:1 and 1:2 complexes, we observed, for the first time, the existence of a Eu(III)–NTA 2:2 complex of millimolar metal and ligand concentrations. Demonstrated for thermodynamic studies on Eu(III) and Cm(III) interaction with complexones, the utilized approach is commonly applicable to many other metal–ligand systems, even to high-affinity ligands. Full article

(This article belongs to the Special Issue Thermodynamics, Structure, and Intermolecular Interactions in Solutions)

► Show Figures

Figure 1

Open AccessArticle

Thermodynamic and Thermal Analyze of N,N-Dimethylformamide + 1-Butanol Mixture Properties Based on Density, Sound Velocity and Heat Capacity Data

by

Magdalena Tyczyńska

,

Aleksandra Dentkiewicz

and

Małgorzata Jóźwiak

Molecules 2023, 28(12), 4698; https://doi.org/10.3390/molecules28124698 - 11 Jun 2023

Viewed by 585

Abstract

The present paper contains data on the density

(ρ)

, sound velocity

(u)

, and specific heat capacity

(c_{p})

of the mixture of N,N-dimethylformamide + 1-butanol (DMF + BuOH) determined in the entire concentration range [...] Read more.

The present paper contains data on the density

(ρ)

, sound velocity

(u)

, and specific heat capacity

(c_{p})

of the mixture of N,N-dimethylformamide + 1-butanol (DMF + BuOH) determined in the entire concentration range of solution and in the temperature range (293.15–318.15) K. The analysis of thermodynamic functions such as isobaric molar expansion, isentropic and isothermal molar compression, isobaric and isochoric molar heat capacity, as well as their excess functions

(E_{p, m}^{E}, K_{S, m}^{E}, K_{T, m}^{E}, C_{p, m}^{E}, C_{V, m}^{E})

and also

V_{m}^{E}

was undertaken. The analysis of changes in the physicochemical quantities was based on consideration of the system in terms of intermolecular interactions and resulting changes in the mixture structure. The results available in the literature were confusing during the analysis and became the reason for our decision to thoroughly examine the system. What is more, for a system whose components are widely used, there is very scarce information in the literature regarding the heat capacity of the tested mixture, which was also achieved and presented in this publication. The conclusions drawn from so many data points allow us to approximate and understand the changes that occur in the structure of the system due to the repeatability and consistency of the obtained results. Full article

(This article belongs to the Special Issue Thermodynamics, Structure, and Intermolecular Interactions in Solutions)

► Show Figures

Figure 1

Open AccessArticle

Europium(III) Meets Etidronic Acid (HEDP): A Coordination Study Combining Spectroscopic, Spectrometric, and Quantum Chemical Methods

by

,

,

,

,

,

and

Molecules 2023, 28(11), 4469; https://doi.org/10.3390/molecules28114469 - 31 May 2023

Viewed by 989

Abstract

Etidronic acid (1-Hydroxyethylidene-1,1-diphosphonic acid, HEDP, H₄L) is a proposed decorporation agent for U(VI). This paper studied its complex formation with Eu(III), an inactive analog of trivalent actinides, over a wide pH range, at varying metal-to-ligand ratios (M:L) and total concentrations. Combining [...] Read more.

Etidronic acid (1-Hydroxyethylidene-1,1-diphosphonic acid, HEDP, H₄L) is a proposed decorporation agent for U(VI). This paper studied its complex formation with Eu(III), an inactive analog of trivalent actinides, over a wide pH range, at varying metal-to-ligand ratios (M:L) and total concentrations. Combining spectroscopic, spectrometric, and quantum chemical methods, five distinct Eu(III)−HEDP complexes were found, four of which were characterized. The readily soluble EuH₂L⁺ and Eu(H₂L)₂⁻ species with log β values of 23.7 ± 0.1 and 45.1 ± 0.9 are formed at acidic pH. At near-neutral pH, EuHL⁰_s forms with a log β of ~23.6 and, additionally, a most probably polynuclear complex. The readily dissolved EuL⁻ species with a log β of ~11.2 is formed at alkaline pH. A six-membered chelate ring is the key motif in all solution structures. The equilibrium between the Eu(III)–HEDP species is influenced by several parameters, i.e., pH, M:L, total Eu(III) and HEDP concentrations, and time. Overall, the present work sheds light on the very complex speciation in the HEDP–Eu(III) system and indicates that, for risk assessment of potential decorporation scenarios, side reactions of HEDP with trivalent actinides and lanthanides should also be taken into account. Full article

(This article belongs to the Special Issue Thermodynamics, Structure, and Intermolecular Interactions in Solutions)

► Show Figures

Figure 1

Open AccessArticle

Stability of the Inclusion Complexes of Dodecanoic Acid with α-Cyclodextrin, β-Cyclodextrin and 2-HP-β-Cyclodextrin

by

Zdzisław Kinart

Molecules 2023, 28(7), 3113; https://doi.org/10.3390/molecules28073113 - 30 Mar 2023

Viewed by 952

Abstract

In the presented work, the stability of the formation of inclusion complexes of dodecanoic acid (lauric acid) with three cyclodextrins, α-cyclodextrin, β-cyclodextrin and 2-HP-β-cyclodextrin, was analyzed from the point of view of the size of the cavity in cyclodextrins, their molar mass and [...] Read more.

In the presented work, the stability of the formation of inclusion complexes of dodecanoic acid (lauric acid) with three cyclodextrins, α-cyclodextrin, β-cyclodextrin and 2-HP-β-cyclodextrin, was analyzed from the point of view of the size of the cavity in cyclodextrins, their molar mass and the structure of the studied fatty acid. The measurements were made in a wide temperature range of 283.15–318.15K. The conductometric method was used for these studies. The results obtained allowed us to determine the value of the theoretical limiting molar conductivity (

Λ_{m}^{0}

) of the studied complexes, the values of the inclusion complex formation constants (K_f) and the values of thermodynamic functions (ΔG⁰, ΔH⁰ and ΔS⁰) describing the complexation process in the studied temperature range. Full article

(This article belongs to the Special Issue Thermodynamics, Structure, and Intermolecular Interactions in Solutions)

► Show Figures

Graphical abstract

Open AccessArticle

Composition of the Solvation Shell of the Selected Cyclic Ethers (1,4-Dioxane, 12-Crown-4, 15-Crown-5 and 18-Crown-6) in a Mixture of Formamide with Water at Four Temperatures

by

Małgorzata Jóźwiak

,

Monika A. Trzmielak

,

Michał Wasiak

and

Katarzyna Łudzik-Dychto

Molecules 2023, 28(5), 2169; https://doi.org/10.3390/molecules28052169 - 26 Feb 2023

Cited by 1 | Viewed by 620

Abstract

The solution enthalpy of 15-crown-5 and 18-crown-6 ethers in the mixture of formamide (F) and water (W) was measured at four temperatures: 293.15 K, 298.15 K, 303.15 K, 308.15 K. The standard molar enthalpy of solution,

Δ_{sol} H^{o}

, depends on [...] Read more.

The solution enthalpy of 15-crown-5 and 18-crown-6 ethers in the mixture of formamide (F) and water (W) was measured at four temperatures: 293.15 K, 298.15 K, 303.15 K, 308.15 K. The standard molar enthalpy of solution,

Δ_{sol} H^{o}

, depends on the size of cyclic ethers molecules and the temperature. With increasing temperature, the values of

Δ_{sol} H^{o}

become less negative. The values of the standard partial molar heat capacity

C_{p, 2}^{o}

of cyclic ethers at 298.15 K have been calculated. The

C_{p, 2}^{o} = f (x_{W})

curve shape indicates the hydrophobic hydration process of cyclic ethers in the range of a high-water content in the mixture with formamide. The enthalpic effect of preferential solvation of cyclic ethers was calculated and the effect of temperature on the preferential solvation process was discussed. The process of complex formation between 18C6 molecules and formamide molecules is observed. The cyclic ethers molecules are preferentially solvated by formamide molecules. The mole fraction of formamide in the solvation sphere of cyclic ethers has been calculated. Full article

(This article belongs to the Special Issue Thermodynamics, Structure, and Intermolecular Interactions in Solutions)

► Show Figures

Graphical abstract

Open AccessArticle

The Group Contribution to the Function Derived from Density and Speed-of-Sound Measurements for Glymes in N,N-Dimethylformamide + Water Mixtures

by

Małgorzata Jóźwiak

,

Marlena Komudzińska

and

Magdalena Tyczyńska

Molecules 2023, 28(4), 1519; https://doi.org/10.3390/molecules28041519 - 04 Feb 2023

Viewed by 605

Abstract

The density and speed of sound of pentaglyme and hexaglyme in the N,N-dimethylformamide + water mixture at four temperatures are presented. The limiting apparent molar volumes (

V_{Φ, m}^{0} = V_{m}^{0}

), the isobaric molar [...] Read more.

The density and speed of sound of pentaglyme and hexaglyme in the N,N-dimethylformamide + water mixture at four temperatures are presented. The limiting apparent molar volumes (

V_{Φ, m}^{0} = V_{m}^{0}

), the isobaric molar thermal expansion (

E_{p, m}^{0}

), the isentropic compressibility (

κ_{S}^{}

), and the limiting partial molar isentropic compression (

K_{S, Φ, m}^{0}

=

K_{S, m}^{0}

) were calculated. Changes in the values obtained from the physicochemical parameters, as functions of composition and temperature, were analyzed in terms of the molecular interactions and structural differentiation of the investigated systems. The hydrophobic hydration process of the studied glymes was visible in the area of high water content in the mixture. The hydration number of glymes in water at four temperatures was calculated and analyzed. The contribution of the –CH₂– and –O– group to the functions describing the volume and acoustic properties of the investigated system was calculated. The calculated values of the functions analyzed using the group contribution are in agreement with the values obtained from the experimental data. Thus, such contributions are valuable for wide ranges of data, which can be used to analyze the hydrophobic hydration and preferential solvation processes, as well as to calculate the values of these functions for other similar compounds. Full article

(This article belongs to the Special Issue Thermodynamics, Structure, and Intermolecular Interactions in Solutions)

► Show Figures

Figure 1

Open AccessArticle

Conductometric Studies of Formation the Inclusion Complexes of Phenolic Acids with β-Cyclodextrin and 2-HP-β-Cyclodextrin in Aqueous Solutions

by

Zdzisław Kinart

Molecules 2023, 28(1), 292; https://doi.org/10.3390/molecules28010292 - 29 Dec 2022

Cited by 1 | Viewed by 1057

Abstract

An attempt was made to evaluate the possibility of creating and assessing the stability of inclusion complexes of selected phenolic acids [trans-4-hydroxycinnamic acid (trans-p-coumaric acid), trans-3,4-dihydroxycinnamic acid (trans-caffeic acid), trans-4-hydroxy-3-methoxycinnamic acid, (trans-ferulic acid) [...] Read more.

An attempt was made to evaluate the possibility of creating and assessing the stability of inclusion complexes of selected phenolic acids [trans-4-hydroxycinnamic acid (trans-p-coumaric acid), trans-3,4-dihydroxycinnamic acid (trans-caffeic acid), trans-4-hydroxy-3-methoxycinnamic acid, (trans-ferulic acid) and trans-3-phenylacrylic acid (trans-cinnamic acid)] with β-cyclodextrin and 2-HP-β-cyclodextrin in aqueous solutions in a wide temperature range 283.15 K–313.15 K. On the basis of the values of the limiting molar conductivity (Λ_CDNaDod), calculated from the experimental data, the values of the formation constants and the thermodynamic functions of formation (standard enthalpy, entropy, and Gibs standard enthalpy) of the studied complexes were determined. It has been found that the stability of the studied complexes increases with lowering of the molar mass of cyclodextrin and lowering of the temperature. Full article

(This article belongs to the Special Issue Thermodynamics, Structure, and Intermolecular Interactions in Solutions)

► Show Figures

Graphical abstract

Open AccessArticle

The Lyotropic Nature of Halates: An Experimental Study

by

,

,

,

,

and

Molecules 2022, 27(23), 8519; https://doi.org/10.3390/molecules27238519 - 03 Dec 2022

Cited by 1 | Viewed by 814

Abstract

Unlike halides, where the kosmotropicity decreases from fluoride to iodide, the kosmotropic nature of halates apparently increases from chlorate to iodate, in spite of the lowering in the static ionic polarizability. In this paper, we present an experimental study that confirms the results [...] Read more.

Unlike halides, where the kosmotropicity decreases from fluoride to iodide, the kosmotropic nature of halates apparently increases from chlorate to iodate, in spite of the lowering in the static ionic polarizability. In this paper, we present an experimental study that confirms the results of previous simulations. The lyotropic nature of aqueous solutions of sodium halates, i.e., NaClO₃, NaBrO₃, and NaIO₃, is investigated through density, conductivity, viscosity, and refractive index measurements as a function of temperature and salt concentration. From the experimental data, we evaluate the activity coefficients and the salt polarizability and assess the anions’ nature in terms of kosmotropicity/chaotropicity. The results clearly indicate that iodate behaves as a kosmotrope, while chlorate is a chaotrope, and bromate shows an intermediate nature. This experimental study confirms that, in the case of halates XO₃⁻, the kosmotropic–chaotropic ranking reverses with respect to halides. We also discuss and revisit the role of the anion’s polarizability in the interpretation of Hofmeister phenomena. Full article

(This article belongs to the Special Issue Thermodynamics, Structure, and Intermolecular Interactions in Solutions)

► Show Figures

Figure 1

Open AccessArticle

Sublimation and Diffusion Kinetics of 2,4,6-Trinitrotoluene (TNT) Single Crystals by Atomic Force Microscopy (AFM)

by

Walid M. Hikal

,

Sanjoy K. Bhattacharia

,

Mark W. Vaughn

and

Brandon L. Weeks

Molecules 2022, 27(17), 5482; https://doi.org/10.3390/molecules27175482 - 26 Aug 2022

Cited by 2 | Viewed by 858

Abstract

In this article, we report the in-situ nanoscale experimental measurement of sublimation rates, activation energy of sublimation, and diffusion coefficients of 2,4,6-trinitrotoluene (TNT) single crystals in air using atomic force microscopy (AFM). The crystals were prepared by slow evaporation at 5 °C using [...] Read more.

In this article, we report the in-situ nanoscale experimental measurement of sublimation rates, activation energy of sublimation, and diffusion coefficients of 2,4,6-trinitrotoluene (TNT) single crystals in air using atomic force microscopy (AFM). The crystals were prepared by slow evaporation at 5 °C using acetone-dissolved TNT. The mass loss was calculated by monitoring the shrinkage of the surface area of layered islands formed on the surface of the TNT crystals due to sublimation upon isothermal heating at temperatures below the melting point. The results suggest the sublimation process occurs via two-dimensional detachment of TNT molecules from the non-prominent facets on the crystal surface which imitates the nucleation and crystal growth process. Sublimation rates are one order of magnitude smaller than previously reported values. However, the calculated activation energy (112.15 ± 3.2 kJ/mol) and temperature-dependent sublimation rates agree well with the reported values for TNT thin films and microcrystals determined by UV-vis absorbance spectroscopy and quartz crystal microscopy (QCM) (90–141 kJ/mol). The average diffusion coefficient is (4.35 × 10^–6 m²/s) which is within the range of the reported theoretical values with an average of 5.59 × 10^–6 m²/s, and about 25% less than that determined using thermogravimetric analysis for powder TNT. Full article

(This article belongs to the Special Issue Thermodynamics, Structure, and Intermolecular Interactions in Solutions)

► Show Figures

Figure 1

Open AccessArticle

Studies of the Formation of Inclusion Complexes Derivatives of Cinnamon Acid with α-Cyclodextrin in a Wide Range of Temperatures Using Conductometric Methods

by

Zdzisław Kinart

and

Renato Tomaš

Molecules 2022, 27(14), 4420; https://doi.org/10.3390/molecules27144420 - 10 Jul 2022

Cited by 2 | Viewed by 1007

Abstract

The electrical conductivities of aqueous solutions of sodium salts of trans-4-hydroxycinnamic acid (trans-p-coumaric acid), trans-3,4-dihydroxycinnamic acid (trans-caffeic acid), trans-4-hydroxy-3-methoxycinnamic acid, (trans-ferulic acid) and trans-3-phenylacrylic acid (trans-cinnamic acid) with α-cyclodextrin [...] Read more.

The electrical conductivities of aqueous solutions of sodium salts of trans-4-hydroxycinnamic acid (trans-p-coumaric acid), trans-3,4-dihydroxycinnamic acid (trans-caffeic acid), trans-4-hydroxy-3-methoxycinnamic acid, (trans-ferulic acid) and trans-3-phenylacrylic acid (trans-cinnamic acid) with α-cyclodextrin were measured in the temperature range of 288.15 K–318.15 K. For the first time in the literature, using the limiting molar conductivity

(Λ_{m}^{o})

obtained from conductivity measurements, the values of the complexation constants (K_f) of the salts of phenolic acid derivatives with α-cyclodextrin were determined using a modified low concentration chemical model (IcCM). An attempt was also made to analyze the individual thermodynamic functions

Δ G^{o}

,

Δ H^{o}

and

Δ S^{o}

describing the complexation process as a function of temperature changes. The obtained results show that the process of formation of inclusion complexes is exothermic and is spontaneous. Full article

(This article belongs to the Special Issue Thermodynamics, Structure, and Intermolecular Interactions in Solutions)

► Show Figures

Graphical abstract

Open AccessArticle

Insight into the Nucleation Mechanism of p-Methoxybenzoic Acid in Ethanol-Water System from Metastable Zone Width

by

,

,

,

,

,

,

and

Molecules 2022, 27(13), 4085; https://doi.org/10.3390/molecules27134085 - 24 Jun 2022

Viewed by 966

Abstract

The metastable zone width (MSZW) of p-methoxybenzoic acid (PMBA) in an ethanol-water system was measured using the polythermal method. The nucleation order m obtained by the Nývlt’s model indicates the nucleation of PMBA following a progressive nucleation mechanism at low saturation temperature [...] Read more.

The metastable zone width (MSZW) of p-methoxybenzoic acid (PMBA) in an ethanol-water system was measured using the polythermal method. The nucleation order m obtained by the Nývlt’s model indicates the nucleation of PMBA following a progressive nucleation mechanism at low saturation temperature (m = 3.18–7.50) and an instantaneous nucleation mechanism at high saturation temperature (m = 1.46–2.55). Then, combined with the metastable zone experiment and the Sangwal model, we found that the MSZW and the interfacial energy reached the maximum when the mass fraction of ethanol was 0.8, which resulted in the smallest crystal product size. Meanwhile, the maximum

r_{c r i t}

and

Δ G_{c r i t}

obtained based on the modified Sangwal model indicating the PMBA needs to overcome a higher nucleation barrier in the ethanol mass fraction of 0.8. Finally, we proposed a preferential strategy for adjusting MSZW by correlating the interfacial energy with the change in ethanol mass fraction, saturation temperature, and cooling rate, respectively. Full article

(This article belongs to the Special Issue Thermodynamics, Structure, and Intermolecular Interactions in Solutions)

► Show Figures

Graphical abstract

Review

Jump to: Research

Open AccessReview

Strategies for Improving Bioavailability, Bioactivity, and Physical-Chemical Behavior of Curcumin

by

,

,

,

,

,

,

,

,

,

Maria Tomoaia-Cotisel

and

Vlad-Alexandru Toma

Molecules 2022, 27(20), 6854; https://doi.org/10.3390/molecules27206854 - 13 Oct 2022

Cited by 13 | Viewed by 2893

Abstract

Curcumin (CCM) is one of the most frequently explored plant compounds with various biological actions such as antibacterial, antiviral, antifungal, antineoplastic, and antioxidant/anti-inflammatory properties. The laboratory data and clinical trials have demonstrated that the bioavailability and bioactivity of curcumin are influenced by the [...] Read more.

Curcumin (CCM) is one of the most frequently explored plant compounds with various biological actions such as antibacterial, antiviral, antifungal, antineoplastic, and antioxidant/anti-inflammatory properties. The laboratory data and clinical trials have demonstrated that the bioavailability and bioactivity of curcumin are influenced by the feature of the curcumin molecular complex types. Curcumin has a high capacity to form molecular complexes with proteins (such as whey proteins, bovine serum albumin, β-lactoglobulin), carbohydrates, lipids, and natural compounds (e.g., resveratrol, piperine, quercetin). These complexes increase the bioactivity and bioavailability of curcumin. The current review provides these derivatization strategies for curcumin in terms of biological and physico-chemical aspects with a strong focus on different type of proteins, characterization methods, and thermodynamic features of protein–curcumin complexes, and with the aim of evaluating the best performances. The current literature review offers, taking into consideration various biological effects of the CCM, a whole approach for CCM-biomolecules interactions such as CCM-proteins, CCM-nanomaterials, and CCM-natural compounds regarding molecular strategies to improve the bioactivity as well as the bioavailability of curcumin in biological systems. Full article

(This article belongs to the Special Issue Thermodynamics, Structure, and Intermolecular Interactions in Solutions)

► Show Figures

Graphical abstract

Journal Menu

Journal Browser

Special Issue "Thermodynamics, Structure, and Intermolecular Interactions in Solutions"

Share This Special Issue

Special Issue Editors

Special Issue Information

Keywords

Related Special Issue

Published Papers (14 papers)

Research

Review

Further Information

Guidelines

MDPI Initiatives

Follow MDPI