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Special Issue "Recent Advances in Metallo-Drugs"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Molecular Structure".

Deadline for manuscript submissions: 31 March 2024 | Viewed by 3401

Special Issue Editor

Special Issue Information

Dear colleagues,

Since the discovery of the anticancer properties of cisplatin (cis-diamminedichloroplatinum (II)) in 1965 and its approval for clinical use in 1978, the investigation of metal complexes as anticancer chemotherapeutic agents has blossomed. Administration of platinum-based drugs has substantial adverse side effects (e.g., neurotoxicity) and is unable to prevent cancer relapse, and intrinsic or acquired resistance can develop in several types of cancer. Thus, many efforts have been made to develop metallo-drugs based on other metals, such as palladium, gold, ruthenium, copper, or osmium. Different types of ligands have also been developed, as well as vehicles to transport the metallo-drug to its targets. Furthermore, in addition to their anticancer properties, metallo-drugs are usable in other fields, for instance, as antibacterial agents.

The Special Issue of Molecules titled “Recent Advances in Metallo-Drugs” welcomes papers related to recent discoveries involving metal complexes in biology/medicine, particularly (but not only) as anticancer agents.

Prof. Dr. Anne-Marie Caminade
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metallo-drugs
  • anticancer
  • biological properties
  • ligands
  • transition metals
  • noble metals

Published Papers (1 paper)

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Review

17 pages, 1476 KiB  
Review
Metal Nanoparticles for Photodynamic Therapy: A Potential Treatment for Breast Cancer
Molecules 2021, 26(21), 6532; https://doi.org/10.3390/molecules26216532 - 29 Oct 2021
Cited by 32 | Viewed by 2740
Abstract
Breast cancer (BC) is the most common malignant tumor in women worldwide, which seriously threatens women’s physical and mental health. In recent years, photodynamic therapy (PDT) has shown significant advantages in cancer treatment. PDT involves activating photosensitizers with appropriate wavelengths of light, producing [...] Read more.
Breast cancer (BC) is the most common malignant tumor in women worldwide, which seriously threatens women’s physical and mental health. In recent years, photodynamic therapy (PDT) has shown significant advantages in cancer treatment. PDT involves activating photosensitizers with appropriate wavelengths of light, producing transient levels of reactive oxygen species (ROS). Compared with free photosensitizers, the use of nanoparticles in PDT shows great advantages in terms of solubility, early degradation, and biodistribution, as well as more effective intercellular penetration and targeted cancer cell uptake. Under the current circumstances, researchers have made promising efforts to develop nanocarrier photosensitizers. Reasonably designed photosensitizer (PS) nanoparticles can be achieved through non-covalent (self-aggregation, interfacial deposition, interfacial polymerization or core-shell embedding and physical adsorption) or covalent (chemical immobilization or coupling) processes and accumulate in certain tumors through passive and/or active targeting. These PS loading methods provide chemical and physical stability to the PS payload. Among nanoparticles, metal nanoparticles have the advantages of high stability, adjustable size, optical properties, and easy surface functionalization, making them more biocompatible in biological applications. In this review, we summarize the current development and application status of photodynamic therapy for breast cancer, especially the latest developments in the application of metal nanocarriers in breast cancer PDT, and highlight some of the recent synergistic therapies, hopefully providing an accessible overview of the current knowledge that may act as a basis for new ideas or systematic evaluations of already promising results. Full article
(This article belongs to the Special Issue Recent Advances in Metallo-Drugs)
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