Structure of Bacterial Proteins
Deadline for manuscript submissions: closed (30 June 2022) | Viewed by 7075
Interests: structural biology; protein crystallography; cryo-electron microscopy; bacterial proteins; Helicobacter pylori; transport proteins
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Bacteria and Archaea, collectively called Prokaryotes, are the most abundant and diverse living organisms of our planet. The most studied species among them are those that are pathogenic for humans, animals or plants, but many others exist and the majority of them have probably not yet been classified. A prokaryotic cell is structurally and functionally much simpler than an eukaryotic one and, in this sense, bacterial or archaeal proteins, easier to obtain in relatively large amount and sometimes to manipulate, have been very often used as models for studying biochemical or biological processes. The knowledge of the 3D structure of bacterial proteins is fundamental, since they can be relevant for human health or may find important biotechnological applications in industrial processes. A searching in the Protein Data Bank, the data base that gathers the coordinates of all the 3D structures published, gives a total of 41392 Bacterial and 3634 Archaeal structures, corresponding to about 25% of the total number of the structures present in the data base. They seem huge numbers, nevertheless it must be considered that they do not identify unique molecules, but the number of different files, part of them corresponding to the same macromolecule in complex with different ligands, or mutants of the same protein, and from them it is hard to estimate the real level of our comprehension of the prokaryotic world at the structural level. This is particularly relevant in view of one of the biggest threats to global health, the antibiotic resistance: in fact, the disegn of new drugs is strongly accelerated if the 3D structure of the target protein is available. The objective of this topical issue in Molecules is to gather papers about the structural aspects of prokaryotic proteins, with the aim of summarizing the state of the art of the field. Ideally, we would like to receive reviews focused about specific classes of bacterial or archaeal proteins, or about the structural studies of a specific prokaryotic organism, or papers that analyze these structures. Also papers describing new structures or new aspects of the structure of prokaryotic proteins are welcome.
Prof. Dr. Giuseppe Zanotti
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- 3D structure
- X-ray diffraction