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Peptide Conjugates as Therapeutic, Diagnostic and Theranostic Agents

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Applied Chemistry".

Deadline for manuscript submissions: closed (30 July 2021) | Viewed by 389

Special Issue Editor

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Guest Editor

Special Issue Information

Dear Colleagues,

There is currently a very active revival of interest in the exploitation of peptides as core tools to develop novel drugs, diagnostics, and theranostics for new high value-added products to address unmet medical needs. This emanates from their biocompatibility, enhanced biochemical characteristics with respect to targeted delivery, and ease in rational design and production. In particular, Peptide–Drug Conjugates (PDCs) are arguably an inextricable accessory in our armamentarium against cancer and are continuously gaining attention as a viable approach to selectively target malignant cells. Besides, conjugation of a bioimaging agent, a drug, or of both modalities to a peptide that targets a specific biomarker expressed in a diseased location in a tissue can result in a potent diagnostic, therapeutic, or theranostic agent. This Special Issue will collect recent advances and developments in the field of peptide conjugation to drugs (PDCs), imaging (diagnostic), or dual modalities (theranostics) against cancer and other diseases, including the rational design and novel methodologies for the synthesis (e.g., rapid click chemistry reactions) of novel peptide conjugates. The contributions will also be focused on the impact of the linker in the overall pharmaceutical profile of peptide conjugates, the interactions with the targeted biomarker, the discovery of novel targets, and the possible side-product formation that may occur during such conjugations.

PDCs consist of three building blocks: the tumor-targeting peptide, the cytotoxic drug, and the biodegradable tether (linker). This Special Issue will collect recent advances in the field of peptide–drug conjugation against cancer, mainly including the rational design of novel peptide–drug conjugates and novel methodologies for their synthesis (e.g., the development of rapid click reactions). The contributions will also be focused on the impact of the linker in the overall pharmaceutical profile of PDCs, the receptor binding interactions, the discovery of novel molecular targets, and the possible side-product formation that may occur during such conjugations.

Prof. Dr. Andreas Tzakos
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • peptide–drug conjugates
  • peptide-based diagnostics
  • peptide-based theranostics
  • rational design
  • cancer research

Published Papers

There is no accepted submissions to this special issue at this moment.
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