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Neuroprotective Effect of Food and Natural Bioactive Compounds 2.0

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 421

Special Issue Editors

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Guest Editor

Special Issue Information

Dear Colleagues,

Neurodegenerative diseases are becoming more relevant in our society. They are different in their pathophysiology and partly determined by the extension of the lifespan.

At present, although there is an increase in research activity on this topic, an effective neuroprotective treatment is still absent. Epidemiological and biochemical studies highlight a significant neuroprotective role of nutrition and natural bioactive compounds, suggesting them as potential therapeutic agents.

Indeed, studies suggest that some natural bioactive components, such as polyphenols, terpenes, vitamins, peptides, and carbohydrates, can positively prevent, delay, or mitigate neurodegenerative disorders.

Nevertheless, the cellular and molecular mechanisms underlying these effects are not yet completely understood. Neuroprotection, by nutrition/bioactive compounds, has been proposed to prevent the onset and progress of diseases by targeting oxidative stress, neurotrophic factor reduction, mitochondrial deficit, apoptosis process, and abnormal protein accumulation.

In order to design effective therapies, it is fundamental to conduct studies aiming to increase our understanding of the bioavailability and pharmacokinetic properties of bioactive compounds.

In this regard, it should be considered that the bioactivity of natural compounds is influenced by metabolic transformations. Additionally, a dependence on the food matrix as well as on the physiology/anatomy of the consumer, and the type of compound, was highlighted in the assessment of the bioavailability of the bioactive compounds.

Therefore, therapeutic strategies should be assessed to develop new delivery systems in order to improve systemic bioavailability and brain penetrance.

This Special Issue of Molecules will include a selection of original articles and reviews aiming to expanding our knowledge on the neuroprotective effects of food/natural compounds, concerning several aspects of different neurodegenerative models.

Prof. Dr. Antonia Patruno
Dr. Mirko Pesce
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • neurodegenerative diseases
  • neuroprotection
  • natural bioactive compound
  • polyphenols

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