Anticancer Bioactivities of Minor Flavonoids
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".
Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 3587
Special Issue Editor
Interests: anticancer actions of natural products; plant polyphenols; flavonoids
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Over the recent decades, a huge number of studies have focused on anticancer activities of plant-derived flavonoids, including structurally different flavanols (or catechins), flavones, flavonols, flavanones, isoflavones and anthocyanidins. These works have revealed important mechanisms how flavonoids can interact with diverse molecular targets and intervene in cellular signaling pathways, leading to prevention or retardation of cancer growth. However, it is well known that plants biosynthesize also other types of flavonoids, known as the so-called minor flavonoids, comprising aurones, chalcones, dihydrochalcones and dihydroflavonols (or flavononols). The current knowledge about bioactivities of minor flavonoids is still much more scarce today, although some studies clearly point to the important anticancer potential of these natural agents. Therefore, this special issue is devoted to different chemopreventive and anticancer effects of minor flavonoids, including their anti/pro-oxidant, antiinflammatory, antiproliferative, proapoptotic, antimigratory, antiinvasive, antiangiogenic and antimetastatic properties, encouraging researchers to explore also the minor types of plant-derived polyphenols. It is highly expected that these studies could result in identification of novel molecular leads for new anticancer agents, expanding our current arsenal in the fight against malignant disorders. Considering the ever-increasing incidence of new cancer cases all over the world in the 21st century, such efforts can be highly valuable from a clinical point of view. Besides review articles, original research papers are very welcomed to be submitted to this special issue to encourage experimental investigation into the field of plant-derived anticancer agents and provide new knowledge about natural sources and possible anticancer effects of little-explored minor phenolics like aurones aureusidin, hispidol, leptosidin and sulfuretin; dihydrochalcones aspalathin, nothofagin and phloretin; flavononols taxifolin, ampelopsin and aromadendrin; and other compounds from these minor but not less important flavonoids` subclasses. Papers about possible co-effects of these natural agents (as well as their semisynthetic derivatives) with conventional cancer treatment modalities are also anticipated in this special issue.
Dr. Katrin Sak
Guest Editor
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Keywords
- plant polyphenols
- minor flavonoids
- anticancer activities
- apoptosis
- metastasis
- angiogenesis
- molecular mechanisms
