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Green Synthesis of Small Heterocyclic Molecules through Multicomponent Approaches

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Green Chemistry".

Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 395

Special Issue Editors

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Guest Editor
School of Chemistry & Physics, University of KwaZulu-Natal, Durban, South Africa
Interests: green synthesis; heterocyclic scaffolds; medicinal chemistry; sustainable synthesis; heterogeneous catalysts
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Chemistry, GITAM School of Sciences, GITAM University, Bangaluru Campus, Bengaluru 561203, India
Interests: synthetic organic chemistry; medicinal chemistry; green chemistry; heterogeneous catalysis; value added conversions
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Developing sustainable synthetic methods for biologically important small heterocyclic target molecules with minimal environmental effects is stimulating. Over the years, new advances to the synthesis of heterocycles are a massive impact on synthetic organic chemistry. The multicomponent reactions (MCRs) generate small heterocycles or utilise them as starting precursors. MCRs simultaneously involve three or more components, developing in products that integrate the elements of all starting substrates in their frameworks. This integrative environment of MCRs is desirable when rapid growth in molecular diversity is preferred. Employing a combinatorial attempt, sets of components can be systematically distributed in arrays of reactions to produce iterations on familiar MCR-product derivatives. New multicomponent domino procedures replace the classical condensation procedures to synthesise heterocyclic compounds. Therefore, developing new approaches to heterocycle synthesis is of significant research interest for green and sustainable research. This topic is crucial for drug development; as a result, greener approaches to heterocyclic molecules are receiving growing attention from the scientific community.

In this perspective, the research topic “Green Synthesis of Small Heterocyclic Molecules through Multicomponent Approaches” Special Issue will be a collection of original research and review articles focusing on heterocyclic compounds synthesis according to green chemistry principles. It will accept some recent advances in heterocycles preparation that employ more sustainable synthetic protocols. The focal point is to build on efficient, sustainable methodologies aiming at high process performances utilising non-toxic/green and biodegradable materials.

Prof. Dr. Sreekantha B. Jonnalagadda
Dr. Nagaraju Kerru
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • multicomponent reactions
  • green/renewable-based solvents
  • green principles
  • one-pot synthesis
  • bio-active compounds
  • heterogeneous catalysis

Published Papers

There is no accepted submissions to this special issue at this moment.
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