Special Issue "Glutathione: Chemistry and Biochemistry"
Deadline for manuscript submissions: closed (30 April 2023) | Viewed by 38506
A printed edition of this Special Issue is available here.
Interests: organic chemistry; medicinal chemistry; chemical biology; bioorganic chemistry; molecular toxicology; glutathione; redox homeostasis, oxidative stress; reactive oxygen species; antioxidants; chemoprevention; chalcones; flavonoids; cyclic chalcone analogs; glutathione conjugation
Special Issues, Collections and Topics in MDPI journals
Glutathione (γ-L-glutamyl-L-cysteinyl-glycine; GSH) is the most abundant low-molecular-weight thiol found in both prokaryotic and eukaryotic organisms. It plays an important role in cellular redox homeostasis, biotransformation of xenobiotics, defense against electrophilic reactive species, and control of several cellular events, among others. Most of these cellular functions are related to the thiol (SH) function of the cysteine moiety. With increasing knowledge on the molecular basis of its functions, the use of GSH as a nutritional supplement is also experiencing increasing interest. The aim of this Special Issue is to review the information gained over recent years regarding the synthesis, physicochemical characterization, and synthetic applications of GSH, as well as on the mechanism and stereochemistry of its enzyme-catalyzed and spontaneous reactions that have a role in cellular functions such as redox control, stress defense, drug biotransformation, and cell signaling. Furthermore, particular attention will also be given to the analytical methodologies used to identify and quantitate GSH conjugates and specific S-glutathionylation reactions.
Communications, full papers, and reviews on the abovementioned topics are particularly welcome.
Prof. Dr. Pál Perjési
Manuscript Submission Information
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- synthesis of GSH and GSH analogs
- redox reactions of GSH
- non-redox reactions of GSH
- GST-catalyzed reactions
- mechanism and stereochemistry of GSH reactions
- stereochemistry of GSH conjugates
- mercapturic acid pathway