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Applications and Medicinal Properties of Terpenoids

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 2179

Special Issue Editors


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Guest Editor
Centro de Investigação de Montanha (CIMO), Instituto Politécnico de Bragança, Campus de Santa Apolónia, 5300-253 Bragança, Portugal
Interests: natural products; natural additives natural anticancer agents; dyes and pigments cytotoxicity; food and chemical toxicology; food safety; organic chemistry
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Centro de Investigação de Montanha (CIMO), Instituto Politécnico de Bragança, Campus de Santa Apolónia, 5300-253 Bragança, Portugal
Interests: bio-based ingredients; stabilization of natural additives; functional foods; extraction optimization; food science and technology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Terpenoids constitute the largest class of plant secondary metabolites and are classified as highly bioactive compounds due to their chemical features, which are responsible for their functional effects. Therefore, this class of compounds is an interesting research topic for the development of biologically active ingredients for industrial application.

Terpenoids have been used in the food, pharmaceutical, and cosmetic industries due to their bioactivities, namely, antitumor, anti-inflammatory, antibacterial, antiviral, antimalarial, hypoglycemic, immunoregulatory, antioxidative, anti-aging, and neuroprotective. They also promote transdermal absorption and are useful in cardiovascular disease prevention and treatment,

Given the high versatility of terpenoids and the wide range of potential benefits, this Special Issue "Applications and Medicinal Properties of Terpenoids" invites researchers to present innovative research or review articles that address the main questions about the application of terpenoids in various industries, including food, pharmaceutical, and cosmetics, including their harmful effects. The main themes to be addressed in this Issue are: i) the development of innovative terpenoid extraction technologies; ii) the characterization of terpenoids; iii) the application of these bioactive molecules and their mechanisms of action, and iv) the development of differentiated formations that contain these molecules.

Dr. Ricardo Calhelha
Dr. Sandrina A. Heleno
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • terpenoids
  • essential oils
  • emerging extraction processes
  • bioactivities

Published Papers (1 paper)

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Research

15 pages, 345 KiB  
Article
Volatile Compounds and Biological Activity of the Essential Oil of Aloysia citrodora Paláu: Comparison of Hydrodistillation and Microwave-Assisted Hydrodistillation
by Rafael M. Sprea, Luís H. M. Fernandes, Tânia C. S. P. Pires, Ricardo C. Calhelha, Pedro João Rodrigues and Joana S. Amaral
Molecules 2023, 28(11), 4528; https://doi.org/10.3390/molecules28114528 - 02 Jun 2023
Cited by 2 | Viewed by 1301
Abstract
Aromatic plants are a remarkable source of natural products. Aloysia citrodora Paláu (Verbenaceae), commonly known as lemon verbena, is a relevant source of essential oils with potential applications due to its lemony scent and bioactive properties. Studies carried out on this species have [...] Read more.
Aromatic plants are a remarkable source of natural products. Aloysia citrodora Paláu (Verbenaceae), commonly known as lemon verbena, is a relevant source of essential oils with potential applications due to its lemony scent and bioactive properties. Studies carried out on this species have focused on the volatile composition of the essential oil obtained by Clevenger hydrodistillation (CHD), with little information available on alternative extraction methodologies or the biological properties of the oil. Therefore, this work aimed to compare the volatile composition, antioxidant activity, cytotoxicity, anti-inflammatory and antibacterial activities of the essential oil extracted by conventional hydrodistillation by Clevenger (CHD) and Microwave-Assisted Hydrodistillation (MAHD). Significant differences (p < 0.05) were observed for some compounds, including the two major ones, geranial (18.7–21.1%) and neral (15.3–16.2%). Better antioxidant activity was exhibited by the MAHD essential oil in DPPH radical scavenging and reducing power assays, while no differences were observed in the cellular antioxidant assay. The MADH essential oil also presented higher inhibition against four tumoral cell lines and exhibited lower cytotoxicity in non-tumoral cells as compared with Clevenger-extracted essential oil. In contrast, the latter showed higher anti-inflammatory activity. Both essential oils were able to inhibit the growth of eleven out of the fifteen bacterial strains tested. Full article
(This article belongs to the Special Issue Applications and Medicinal Properties of Terpenoids)
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