Amide Bond Activation II
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".
Deadline for manuscript submissions: closed (15 September 2021) | Viewed by 6659
Special Issue Editor
Interests: amide bonds; N-heterocyclic carbenes; C-N activation; C-H activation; C-O activation; lanthanides; cross-coupling; catalysis; reductions; reductive couplings; radical chemistry; synthetic methodology; natural products
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
In 2018, we edited the Special Issue "Amide Bond Activation" of Molecules. After peer review, 24 excellent papers were published addressing various aspects of amide bonds and amide bond activation. Amide bonds are of interest to the broad audience of the journal. Therefore, we decided to establish a Special Issue Series on this topic and launch the second Special Issue, namely "Amide Bond Activation II"
The amide bond represents a privileged motif in chemistry. One fascinating feature of the amide bond is the innate stability achieved by delocalization of the nitrogen lone pair into the carbonyl group. Defying conventional knowledge that characterizes the amide bond as one of the most robust functional groups in synthetic chemistry, recent years have witnessed an explosion of interest in the development of new chemical transformations of amides. An important trend involves chemoselective activation of the N–C amide bond by metal insertion. This thriving class of reactions originates from the classic studies on amide bond destabilization and has the potential to become a widely applicable cross-coupling platform. More generally, N–C bond activation emphasizes the significance of ubiquitous amide bonds to participate in a wide range of electrophilic, Lewis acid, radical, and nucleophilic reaction pathways, among other transformations. These methods are beneficial to chemists because they supply valuable compounds by functional group interconversion or functionalization of amides on the fundamental level. Equally relevant are structural and theoretical studies that provide the basis for chemoselective manipulation of amidic resonance. This Special Issue will provide a broad survey of recent advances in the activation of amides and address various approaches in the field. This Special Issue will contain contributions describing multifaceted aspects of this field. Review articles by experts in the field are also welcome.
Prof. Dr. Michal Szostak
Guest Editor
Manuscript Submission Information
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Keywords
- Amides
- Amide bond
- Bond functionalization
- Functional group interconversion
- Organic synthesis
- Cross-coupling
- Catalysis
- N–C activation
- Esters
- O–C activation
- Resonance
- Planarity
- Winkler-Dunitz parameters
- Twisted amides
