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Molecules
Special Issues
Preparation and Applications of Biological Active Agents
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Preparation and Applications of Biological Active Agents

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: closed (1 June 2021) | Viewed by 4175

Special Issue Editor

Prof. Dr. Anton Ficai

E-Mail Website
Guest Editor
1. Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, 1-7 Gh. Polizu St., 011061 Bucharest, Romania
2. Academy of Romanian Scientists, 54 Splaiul Independenței St., Bucharest, Romania
Interests: bio(nano)materials; synthesis methods; materials processing and design; advanced coatings; tissue engineering; drug delivery; characterization methods
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues:

This Special Issue intends to highlight the most recent advances in the field of developing and using biological active agents in treating different diseases including cancer, severe infections (with viral or bacterial etiology), etc. Along with the design and development of biological active agents and the extraction from natural sources, a special attention will be paid to different administration pathways as well as to the prevention of the spreading of infections and cancer. Manuscripts related to smart and targeted delivery are especially welcome. The use of computational chemistry in identifying potential biological active agents is especially welcome, as are manuscripts which exploit this field.

Prof. Dr. Anton Ficai
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Biological active agents: design, preparation and evaluation
  • Active agents and administration pathway
  • Computational chemistry
  • Use of biological active agents in treatment and protection

Published Papers (1 paper)

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Research

16 pages, 2921 KiB  
Article
Propolis-Based Nanofiber Patches to Repair Corneal Microbial Keratitis
by Songul Ulag, Elif Ilhan, Ramazan Demirhan, Ali Sahin, Betul Karademir Yilmaz, Burak Aksu, Mustafa Sengor, Denisa Ficai, Aurel Mihail Titu, Anton Ficai and Oguzhan Gunduz
Molecules 2021, 26(9), 2577; https://doi.org/10.3390/molecules26092577 - 28 Apr 2021
Cited by 32 | Viewed by 3009
Abstract
In this research, polyvinyl-alcohol (PVA)/gelatin (GEL)/propolis (Ps) biocompatible nanofiber patches were fabricated via electrospinning technique. The controlled release of Propolis, surface wettability behaviors, antimicrobial activities against the S. aureus and P. aeruginosa, and biocompatibility properties with the mesenchymal stem cells (MSCs) were [...] Read more.
In this research, polyvinyl-alcohol (PVA)/gelatin (GEL)/propolis (Ps) biocompatible nanofiber patches were fabricated via electrospinning technique. The controlled release of Propolis, surface wettability behaviors, antimicrobial activities against the S. aureus and P. aeruginosa, and biocompatibility properties with the mesenchymal stem cells (MSCs) were investigated in detail. By adding 0.5, 1, and 3 wt.% GEL into the 13 wt.% PVA, the morphological and mechanical results suggested that 13 wt.% PVA/0.5 wt.% GEL patch can be an ideal matrix for 3 and 5 wt.% propolis addition. Morphological results revealed that the diameters of the electrospun nanofiber patches were increased with GEL (from 290 nm to 400 nm) and Ps addition and crosslinking process cause the formation of thicker nanofibers. The tensile strength and elongation at break enhancement were also determined for 13 wt.% PVA/0.5 wt.% GEL/3 wt.% Ps patch. Propolis was released quickly in the first hour and arrived at a plateau. Cell culture and contact angle results confirmed that the 3 wt.% addition of propolis reinforced mesenchymal stem cell proliferation and wettability properties of the patches. The antimicrobial activity demonstrated that propolis loaded patches had antibacterial activity against the S. aureus, but for P. aeruginosa, more studies should be performed. Full article
(This article belongs to the Special Issue Preparation and Applications of Biological Active Agents)
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