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Exclusive Papers of the Editorial Board Members (EBMs): Advances in...
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Exclusive Papers of the Editorial Board Members (EBMs): Advances in Bioorganic Chemistry

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Bioorganic Chemistry".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 1899

Special Issue Editors

Prof. Dr. Riccardo Spaccini

E-Mail Website
Guest Editor
Department of Agricultural Sciences, University of Napoli Federico II, Portici, Italy
Interests: biomasse recycling; structural activity relationship; molecular characterization
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Annemieke Madder

E-Mail Website
Guest Editor
Organic and Biomimetic Chemistry Research Group, Ghent University, Krijgslaan 281, 9000 Ghent, Belgium
Interests: reactive peptide and oligonucleotide probes; peptide and protein labeling; nucleic acid crosslinking; artificial receptors; CLP synthesis

Special Issue Information

Dear Colleagues,

This Special Issue of Molecules is dedicated to recent advances in bioorganic chemistry research areas and comprises a diverse selection of exclusive papers from the Editorial Board Members (EBMs) of the Bioorganic Chemistry Section. It aims to highlight recent interesting investigations conducted in the laboratories of our section’s EBMs and display our section as an attractive open-access publishing platform for bioorganic chemistry research data.

Prof. Dr. Riccardo Spaccini
Prof. Dr. Annemieke Madder
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (2 papers)

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Research

16 pages, 1625 KiB  
Article
Rational Design, Synthesis, and Anti-Proliferative Evaluation of Novel 4-Aryl-3,4-Dihydro-2H-1,4-Benzoxazines
by Xiaoming Fu, Daniel Wenholz, Daniel S. H. Chan, David StC. Black and Naresh Kumar
Molecules 2024, 29(1), 166; https://doi.org/10.3390/molecules29010166 - 27 Dec 2023
Viewed by 615
Abstract
A synthetic pathway to a novel 4-aryl-3,4-dihydro-2H-1,4-benzoxazine scaffold was developed and a series of compounds based on the scaffold were synthesised as potential anticancer agents. The 4-aryl-substituted compounds were prepared via Buchwald–Hartwig cross-coupling between substituted bromobenzenes and various 1,4-benzoxazines, which in [...] Read more.
A synthetic pathway to a novel 4-aryl-3,4-dihydro-2H-1,4-benzoxazine scaffold was developed and a series of compounds based on the scaffold were synthesised as potential anticancer agents. The 4-aryl-substituted compounds were prepared via Buchwald–Hartwig cross-coupling between substituted bromobenzenes and various 1,4-benzoxazines, which in turn were generated from a cascade hydrogenation and reductive amination one-pot reaction. These analogues exhibited moderate to good potency against various cancer cell lines. Structure–activity relationship analysis indicated that the inclusion of hydroxyl groups on ring A and ring B was beneficial to biological activity, while having a para-amino group on ring C significantly enhanced potency. Molecule 14f displayed the most potent anticancer activity (IC50 = 7.84–16.2 µM against PC-3, NHDF, MDA-MB-231, MIA PaCa-2, and U-87 MG cancer cell lines), indicating its potential as a lead compound for further structural optimisation. All the synthesised compounds were fully characterised with NMR, HMRS, and IR. The novel benzoxazine scaffold described in this study holds promise and deserves further in-depth studies. Full article
(This article belongs to the Special Issue Exclusive Papers of the Editorial Board Members (EBMs): Advances in Bioorganic Chemistry)
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16 pages, 2311 KiB  
Article
Developing an Amide-Spacered Triterpenoid Rhodamine Hybrid of Nano-Molar Cytotoxicity Combined with Excellent Tumor Cell/Non-Tumor Cell Selectivity
by Niels V. Heise, Toni C. Denner, Selina Becker, Sophie Hoenke and René Csuk
Molecules 2023, 28(17), 6404; https://doi.org/10.3390/molecules28176404 - 01 Sep 2023
Viewed by 986
Abstract
Asiatic acid, a pentacyclic triterpene, was converted into a series of piperazinyl, homopiperazinyl, and 1,5-diazocinyl spacered rhodamine conjugates, differing in the type of spacer and the substitution pattern on the rhodamine moiety of the hybrids. The compounds were tested for cytotoxic activity in [...] Read more.
Asiatic acid, a pentacyclic triterpene, was converted into a series of piperazinyl, homopiperazinyl, and 1,5-diazocinyl spacered rhodamine conjugates, differing in the type of spacer and the substitution pattern on the rhodamine moiety of the hybrids. The compounds were tested for cytotoxic activity in SRB assays and compound 12, holding an EC50 of 0.8 nM, was the most cytotoxic compound of this series, but compound 18 (containing a ring expanded 1,5-diazocinyl moiety and n-propyl substituents on the rhodamine) was the most selective compound exhibiting a selectivity factor of almost 190 while retaining high cytotoxicity (EC50 = 1.9 nM, for A2780 ovarian carcinoma). Full article
(This article belongs to the Special Issue Exclusive Papers of the Editorial Board Members (EBMs): Advances in Bioorganic Chemistry)
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