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Radiotracers in Drug Discovery and Development

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: 30 August 2024 | Viewed by 79

Special Issue Editor


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Guest Editor
Vaccine Translational Research Branch/VRP/DAIDS, National Institute of Allergy and Infectious Diseases (NIH), 5601 Fishers Lane, Room 9B56, Rockville, MD 20892, USA
Interests: radiotracers; drug discovery; drug development; biomarkers; end point; therapeutic effect; drug efficacy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Significant advances in the design and evaluation of novel radiopharmaceuticals in preclinical and clinical environments have enabled the wider adoption of imaging technologies such as SPECT and PET for oncological, cardiological, and neurological applications. Numerous radiopharmaceuticals have become available commercially for various applications, and more are going through development and the regulatory approval process. These radiopharmaceuticals are critical to the diagnosis and staging of diseases as well as to the selection of patients for various therapies and the monitoring of their outcomes.

Radiotracers play a crucial role in the drug discovery and development environments that advance preclinical and clinical studies and lead to commercialization. For example, radiotracers are used for target identification and optimization, specific/non-specific receptor binding, in vitro/in vivo stability, biodistribution, pharmacokinetics, and ADME (adsorption, distribution, metabolism, and excretion) studies in animal models in a preclinical environment. Molecular imaging using radiotracers provides accurate information related to the effective dose and dosing interval determination, drug efficacy, the therapeutic responses of a drug candidate, the binding of a drug candidate with biological targets, the evaluation of the therapeutic effects of drugs, drug–receptor interactions, brain penetration and metabolism, pharmacokinetics, and the mechanisms of drug action, resistance, and endpoint determination. Imaging modalities with radiotracers also visualize and measure the rates of various physiological processes at the molecular level in vivo; these include glucose metabolism, neurotransmitters, uptake, blood flow, etc., in various oncological, cardiovascular, and neurological conditions.

The Editorial Team of Molecules is developing a Special Issue entitled “Radiotracers and Drug Discovery and Development”. This Special Issue will focus on all aspects of the design, characterization, evaluation, and development of novel radiotracers for drug development.

Both original research papers and reviews related to the areas mentioned above are welcome.

Dr. Krishan Kumar
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • radiotracers
  • drug discovery
  • drug development
  • biomarkers
  • end point
  • therapeutic effect
  • drug efficacy

Published Papers

This special issue is now open for submission.
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