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Innovate Sensors for Sensitive Determination for Bioactive Compounds
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Innovate Sensors for Sensitive Determination for Bioactive Compounds

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Analytical Chemistry".

Deadline for manuscript submissions: closed (29 February 2024) | Viewed by 5734

Special Issue Editor

Dr. Mahmoud Amouzadeh Tabrizi

E-Mail Website
Guest Editor
Department of Chemistry, University of Massachusetts, Amherst, MA, USA
Interests: electrochemistry; nanomaterials; aptasensors; immunosensors; optical biosensors; molecular force sensor
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Recently, sensor technologies have undergone rapid growth, offering an excellent opportunity to detect bioactive compounds (BACs). The footprint of BACs is found in various biological phenomena such as cell signaling, cell growing, metastasis, and so on. Therefore, it is essential to fabricate a sensor to detect them at a trace level.

Among the various techniques that have been used for the detection of BACs, electrochemical and optical approaches are the most interesting ones for several reasons, such as their possibility to integrate with nanomaterials, and microchips that dramatically improve the analytical performances of the sensors in the term of liner response range, sensitivity, stability, etc. Indeed, the integration of sensors with nano/micro devices such as microfluidics will pave the way to fabricate low-cost, autonomous, and rapid response tools such as lab-on-a-chip sensors. This Special Issue intends to collect novel sensing technologies that can be used for the detection of BACs in real samples such as environmental, food, and biological samples. Original papers that describe novel biosensors for the detection of BACs based on aptamers, enzymes, and antibodies are most welcome. Review articles should address recent advances in sensor technologies to detect bioactive compounds. We look forward to receiving your manuscript.

Dr. Mahmoud Amouzadeh Tabrizi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biosensors
  • bioimaging
  • nanomaterial-based sensors
  • point of care
  • biomarker detection
  • paper-based biosensors
  • lab-on-a-chip biosensors
  • integrated biosensors

Published Papers (4 papers)

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Research

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20 pages, 4875 KiB  
Article
Lignosulfonate-Assisted In Situ Deposition of Palladium Nanoparticles on Carbon Nanotubes for the Electrocatalytic Sensing of Hydrazine
by Patrycja Płócienniczak-Bywalska, Tomasz Rębiś, Amanda Leda and Grzegorz Milczarek
Molecules 2023, 28(20), 7076; https://doi.org/10.3390/molecules28207076 - 13 Oct 2023
Cited by 1 | Viewed by 785
Abstract
This paper presents a novel modified electrode for an amperometric hydrazine sensor based on multi-walled carbon nanotubes (MWCNTs) modified with lignosulfonate (LS) and decorated with palladium nanoparticles (NPds). The MWCNT/LS/NPd hybrid was characterized by atomic force microscopy (AFM), X-ray photoelectron spectroscopy (XPS), and [...] Read more.
This paper presents a novel modified electrode for an amperometric hydrazine sensor based on multi-walled carbon nanotubes (MWCNTs) modified with lignosulfonate (LS) and decorated with palladium nanoparticles (NPds). The MWCNT/LS/NPd hybrid was characterized by atomic force microscopy (AFM), X-ray photoelectron spectroscopy (XPS), and X-ray diffraction (XRD). The electrochemical properties of the electrode material were evaluated using cyclic voltammetry and chronoamperometry. The results showed that GC/MWCNT/LS/NPd possesses potent electrocatalytic properties towards the electro-oxidation of hydrazine. The electrode demonstrated exceptional electrocatalytic activity coupled with a considerable sensitivity of 0.166 μA μM−1 cm−2. The response was linear from 3.0 to 100 µM L−1 and 100 to 10,000 µM L−1, and the LOD was quantified to 0.80 µM L−1. The efficacy of the modified electrode as an electrochemical sensor was corroborated in a study of hydrazine determination in water samples. Full article
(This article belongs to the Special Issue Innovate Sensors for Sensitive Determination for Bioactive Compounds)
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15 pages, 5411 KiB  
Article
A Turn-On Quinazolinone-Based Fluorescence Probe for Selective Detection of Carbon Monoxide
by Akari Tange, Naoya Kishikawa, Yusuke Sakamoto, Mahmoud El-Maghrabey, Mitsuhiro Wada and Naotaka Kuroda
Molecules 2023, 28(9), 3654; https://doi.org/10.3390/molecules28093654 - 22 Apr 2023
Viewed by 1253
Abstract
Carbon monoxide (CO) is a toxic, hazardous gas that has a colorless and odorless nature. On the other hand, CO possesses some physiological roles as a signaling molecule that regulates neurotransmitters in addition to its hazardous effects. Because of the dual nature of [...] Read more.
Carbon monoxide (CO) is a toxic, hazardous gas that has a colorless and odorless nature. On the other hand, CO possesses some physiological roles as a signaling molecule that regulates neurotransmitters in addition to its hazardous effects. Because of the dual nature of CO, there is a need to develop a sensitive, selective, and rapid method for its detection. Herein, we designed and synthesized a turn-on fluorescence probe, 2-(2′-nitrophenyl)-4(3H)-quinazolinone (NPQ), for the detection of CO. NPQ provided a turn-on fluorescence response to CO and the fluorescence intensity at 500 nm was increased with increasing the concentration of CO. This fluorescence enhancement could be attributed to the conversion of the nitro group of NPQ to an amino group by the reducing ability of CO. The fluorescence assay for CO using NPQ as a reagent was confirmed to have a good linear relationship in the range of 1.0 to 50 µM with an excellent correlation coefficient (r) of 0.997 and good sensitivity down to a limit of detection at 0.73 µM (20 ppb) defined as mean blank+3SD. Finally, we successfully applied NPQ to the preparation of a test paper that can detect CO generated from charcoal combustion. Full article
(This article belongs to the Special Issue Innovate Sensors for Sensitive Determination for Bioactive Compounds)
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12 pages, 2115 KiB  
Article
Portable Wireless Intelligent Electrochemical Sensor for the Ultrasensitive Detection of Rutin Using Functionalized Black Phosphorene Nanocomposite
by Fan Shi, Yijing Ai, Baoli Wang, Yucen Yao, Zejun Zhang, Juan Zhou, Xianghui Wang and Wei Sun
Molecules 2022, 27(19), 6603; https://doi.org/10.3390/molecules27196603 - 05 Oct 2022
Cited by 4 | Viewed by 1507
Abstract
To build a portable and sensitive method for monitoring the concentration of the flavonoid rutin, a new electrochemical sensing procedure was established. By using nitrogen-doped carbonized polymer dots (N-CPDs) anchoring few-layer black phosphorene (N-CPDs@FLBP) 0D-2D heterostructure and gold nanoparticles (AuNPs) as the modifiers, [...] Read more.
To build a portable and sensitive method for monitoring the concentration of the flavonoid rutin, a new electrochemical sensing procedure was established. By using nitrogen-doped carbonized polymer dots (N-CPDs) anchoring few-layer black phosphorene (N-CPDs@FLBP) 0D-2D heterostructure and gold nanoparticles (AuNPs) as the modifiers, a carbon ionic liquid electrode and a screen-printed electrode (SPE) were used as the substrate electrodes to construct a conventional electrochemical sensor and a portable wireless intelligent electrochemical sensor, respectively. The electrochemical behavior of rutin on the fabricated electrochemical sensors was explored in detail, with the analytical performances investigated. Due to the electroactive groups of rutin, and the specific π-π stacking and cation–π interaction between the nanocomposite with rutin, the electrochemical responses of rutin were greatly enhanced on the AuNPs/N-CPDs@FLBP-modified electrodes. Under the optimal conditions, ultra-sensitive detection of rutin could be realized on AuNPs/N-CPDs@FLBP/SPE with the detection range of 1.0 nmol L−1 to 220.0 μmol L−1 and the detection limit of 0.33 nmol L−1 (S/N = 3). Finally, two kinds of sensors were applied to test the real samples with satisfactory results. Full article
(This article belongs to the Special Issue Innovate Sensors for Sensitive Determination for Bioactive Compounds)
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Review

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17 pages, 7297 KiB  
Review
Meldrum’s Acid Furfural Conjugate MAFC: A New Entry as Chromogenic Sensor for Specific Amine Identification
by Lisa Zeußel and Sukhdeep Singh
Molecules 2023, 28(18), 6627; https://doi.org/10.3390/molecules28186627 - 14 Sep 2023
Cited by 1 | Viewed by 1330
Abstract
Bioactive amines are highly relevant for clinical and industrial application to ensure the metabolic status of a biological process. Apart from this, generally, amine identification is a key step in various bioorganic processes ranging from protein chemistry to biomaterial fabrication. However, many amines [...] Read more.
Bioactive amines are highly relevant for clinical and industrial application to ensure the metabolic status of a biological process. Apart from this, generally, amine identification is a key step in various bioorganic processes ranging from protein chemistry to biomaterial fabrication. However, many amines have a negative impact on the environment and the excess intake of amines can have tremendous adverse health effects. Thus, easy, fast, sensitive, and reliable sensing methods for amine identification are strongly searched for. In the past few years, Meldrum’s acid furfural conjugate (MAFC) has been extensively explored as a starting material for the synthesis of photoswitchable donor–acceptor Stenhouse adducts (DASA). DASA formation hereby results from the rapid reaction of MAFC with primary and secondary amines, which has so far been demonstrated through numerous publications for different applications. The linear form of the MAFC-based DASA exhibits intense pink coloration due to its linear conjugated triene-2-ol conformation, which has inspired researchers to use this easy synthesizable molecule as an optical sensor for primary, secondary, and biogenic amines. Due to its new entry into amine identification, a collection of the literature exclusively on MAFC is demanded. In this mini review, we intend to present the state-of-the-art of MAFC as an optical molecular sensor in hopes to motivate researchers to find even more applications of MAFC-based sensors and methods that pave the way to their usage in medicinal applications. Full article
(This article belongs to the Special Issue Innovate Sensors for Sensitive Determination for Bioactive Compounds)
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