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Antioxidant Nanomaterials for Biomedical Applications

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Nanochemistry".

Deadline for manuscript submissions: 31 March 2024 | Viewed by 976

Special Issue Editors

Obesity Research Center, College of Medicine, King Saud University, Riyadh 11461, Saudi Arabia
Interests: biomaterials; biomedical applications; nanomaterials; cardiovascular pathology
Special Issues, Collections and Topics in MDPI journals
Center of Excellence for Research in Engineering Materials (CEREM), College of Engineering, King Saud University, Riyadh 11421, Saudi Arabia
Interests: nanoparticles; nanocomposites; antibacterial activity; cerium oxide nanoparticles
Special Issues, Collections and Topics in MDPI journals
Department of Botany and Microbiology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia
Interests: microbiology; cellulose nanoparticles; antibacterial; antifungal; anticancer potential

Special Issue Information

Dear Colleagues,

An increase in the generation of reactive oxygen species (ROS) is implicated in the development of numerous disorders such as cardiovascular diseases, atherosclerosis, neurodegenerative, cancer, etc. Under normal conditions, minimal ROS generation is required for maintaining certain cellular processes in an organism, and the balance is sustained by a tightly coupled defensive antioxidant system that works in coordination to maintain redox homeostasis. While under pathological conditions, an imbalance between the levels of antioxidants and ROS leads to a phenomenon called oxidative stress. Thus, the use of exogenous antioxidants is considered an important therapeutic option to reduce the risk of oxidative stress-induced health conditions. Though the use of antioxidants has been reported to play a vital role in combating free radical-induced damage in an organism, these antioxidants have certain limitations, in particular, the degradation during delivery is attributed to their reduced bioavailability. Thus, from this perspective, different types of metal and metal oxide nanoparticles of gold, platinum, and cerium have received special attention and made tremendous progress in multiple biomedical applications.

This Special Issue aims to provide the research community with recent advances in the field of antioxidant nanomaterials developed for biomedical and therapeutic applications. Researchers are cordially invited to submit original articles which revolve around research in nanomaterials. Review articles summarizing the current knowledge on antioxidant nanomaterials and their applications will also be of interest.

Dr. Rukhsana Gul
Dr. Mushtaq A. Dar
Dr. Karuppiah Ponmurugan
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • nanotechnology
  • nanobiomedicine
  • reactive oxygen species
  • antioxidant defense system
  • oxidative stress

Published Papers (1 paper)

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24 pages, 5403 KiB  
The Characterization and Study of Antibacterial, Free Radical Scavenging, and Anticancer Potential of Livistona chinensis-Mediated Silver Nanoparticles
Molecules 2023, 28(23), 7773; - 25 Nov 2023
Viewed by 735
In the present research, Livistona chinensis leaf extracts were utilized as reductants to bio-fabricate silver nanoparticles (LC-AgNPs) and this was followed by the evaluation of their antioxidant, antibacterial, and anticancer potential. Multiple parameters were optimized for the formation and fidelity of LC-AgNPs. The [...] Read more.
In the present research, Livistona chinensis leaf extracts were utilized as reductants to bio-fabricate silver nanoparticles (LC-AgNPs) and this was followed by the evaluation of their antioxidant, antibacterial, and anticancer potential. Multiple parameters were optimized for the formation and fidelity of LC-AgNPs. The color shift of the reaction mixture from yellow to dark brown confirmed the LC-AgNPs formation. UV/VIS spectroscopy exhibited a surface plasmon resonance (SPR) band at 436 nm. The Fourier transform infrared (FTIR) spectroscopy spectrum depicted phytochemicals in the plant extract acting as bio-reducers for LC-AgNPs synthesis. The XRD pattern confirmed the presence of LC-AgNPs by showing peaks corresponding to 2θ angle at 8.24° (111), 38.16° (200), 44.20° (220), and 64.72° (311). Zetasizer analysis exhibited size distribution by intensity of LC-AgNPs with a mean value of 255.7 d. nm. Moreover, the zeta potential indicated that the AgNPs synthesized were stable. The irregular shape of LC-AgNPs with a mean average of 38.46 ± 0.26 nm was found by scanning electron microscopy. Furthermore, the antioxidant potential of LC-AgNPs was examined using a DPPH assay and was calculated to be higher in LC-AgNPs than in leaf extracts. The calculated IC50 values of the LC-AgNPs and plant extract are 85.01 ± 0.17 and 209.44 ± 0.24, respectively. The antibacterial activity of LC-AgNPs was investigated against Escherichia coli, Pseudomonas aeruginosa, and Bacillus subtilis as well as Staphylococcus aureus, and maximum potential was observed after 24 h against P. aeruginosa. Moreover, LC-AgNPs exhibited maximum anticancer potential against TPC1 cell lines compared to the plant extract. The findings suggested that LC-AgNPs could be used as antioxidant, antibacterial, and anticancer agents for the cure of free-radical-oriented bacterial and oncogenic diseases. Full article
(This article belongs to the Special Issue Antioxidant Nanomaterials for Biomedical Applications)
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