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Isolation, Analysis, and Application of Characteristic Compounds from Natural Product and Synthesis of Their Analogue

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: closed (15 December 2023) | Viewed by 3868

Special Issue Editor


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Guest Editor
Department of Food Science and Technology, Chungnam National University, 99 Daehak-ro, Yuseong-gu, Daejeon 34134, Republic of Korea
Interests: functional lipids; modification of lipid compounds; lipid oxidation; flavor compounds; human milk; emulsion; process of distilled spirit production; quantitative analysis; nutrient database; phospholipids; Steglich reaction; industrial isolation process
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Natural products such as agricultural, fishery and livestock products contain specific compounds that are beneficial to human health and play an important role through physiological activity when ingested. In modern society, extending the healthy lifespan has become an important social issue, and thus industry has taken a special interest in the commercialization of these compounds. To this end, economic separation and analysis of specific compounds are required; furthermore, it is necessary to pursue the production of high-added-value products through the useful transformation of specific compounds.

This Special Issue is focused on the analysis of characteristic compounds of natural products. Examples of such compounds are neutral lipids and specific fatty acids, phospholipids, anthocyanins, lignans, alkaloids, carotenoids, sterols, vitamins, minerals, etc. Topics to be covered will include quantitative analysis for determining the number of compounds contained in various natural products along with the development of analysis methods, comparison between these methods and their improvement in targeting these compounds.

Examples of such techniques include the isolation method for phospholipids contained in specific natural products, such as phosphatidyl choline and phosphatidyl ethanolamine, quantitative analysis using HPLC-ELSD, MS/MS or 31P-NMR and scaled-up isolation methods for industrial application.

Furthermore, it is possible to convert these specific compounds isolated from natural products or by already commercialized by enzymatic and chemical methods into industrially high-value-added forms (e.g., materials for mRNA vaccines). For this purpose, a conversion method is used, which can be commercialized along with separation, purification and identification methods from a reactant.

This Special Issue, “Isolation, Analysis, and Application of Characteristic Compounds from Natural Product and Synthesis of Their Analogue”, welcomes original research on:

1) Methods of isolation and analysis of characteristic compounds from natural products;

2) Methods of chemical or enzymatic reaction for modification of characteristic compounds with the downstream process (extraction, isolation, identification, characterization, application, etc.).

Dr. Ki-Teak Lee
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural products
  • isolation
  • quantitative analysis
  • identification
  • chemical and enzymatic modification
  • physico-chemical properties

Published Papers (2 papers)

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Research

15 pages, 3368 KiB  
Article
Synthesis of Silver Nanoparticles by Leaf Extract of Cucumis melo L. and Their In Vitro Antidiabetic and Anticoccidial Activities
by Pushpa Rani, Naveen Kumar, Kantharaj Perinmbam, Sandhanasamy Devanesan, Mohamad S. AlSalhi, Nassar Asemi and Marcello Nicoletti
Molecules 2023, 28(13), 4995; https://doi.org/10.3390/molecules28134995 - 26 Jun 2023
Cited by 2 | Viewed by 1320
Abstract
In this study, silver nanoparticles were synthesized using Cucumis melo L. leaf extract via a green synthesis approach and their potential against diabetes and coccidiosis was tested under in vitro conditions. The phytochemical components in the leaf extract reacted with silver nitrate in [...] Read more.
In this study, silver nanoparticles were synthesized using Cucumis melo L. leaf extract via a green synthesis approach and their potential against diabetes and coccidiosis was tested under in vitro conditions. The phytochemical components in the leaf extract reacted with silver nitrate in solution and yielded C. melo-silver nanoparticles (Cm-AgNPs). The synthesis of AgNPs was confirmed via UV–visible spectroscopy by obtaining a peak at 440 nm. The nanoparticles were characterized by their morphology, crystallinity, and the presence of functional groups. In vitro α-amylase and α-glucosidase inhibition assays were carried out at different concentrations in the range of 20 to 100 μg/mL of Cm-AgNPs. The Cm-AgNPs exhibited enzyme inhibitory activity in a concentration-dependent manner. As the concentration of Cm-AgNPs increased the inhibitory activities were also increased linearly and the highest inhibition was observed at 100 μg/mL. The effectiveness of Cm-AgNPs against Eimeria tenalla was assessed by an in vitro 3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide (MTT) assay using Madin–Darby bovine kidney (MDBK) cell lines. The results revealed that the viability of the oocysts and further sporulation were decreased with the increased concentration of Cm-AgNPs. The AgNPs synthesized from the C. melo leaf extract have shown promising potential against diabetes and coccidiosis, and they could be used in biomedical applications. Full article
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17 pages, 1250 KiB  
Article
Phytochemical Screening and Antioxidant Activity of Selected Estonian Galium Species
by Pille-Riin Laanet, Piret Saar-Reismaa, Piia Jõul, Olga Bragina and Merike Vaher
Molecules 2023, 28(6), 2867; https://doi.org/10.3390/molecules28062867 - 22 Mar 2023
Cited by 7 | Viewed by 2178
Abstract
The aim of the present study was to examine three different Galium species from the native population of Estonia, Galium verum, Galium aparine, and Galium mollugo, to characterise their non-volatile and volatile phytochemical composition and antioxidant activity. The main groups [...] Read more.
The aim of the present study was to examine three different Galium species from the native population of Estonia, Galium verum, Galium aparine, and Galium mollugo, to characterise their non-volatile and volatile phytochemical composition and antioxidant activity. The main groups of bioactive compounds in the plants were quantified by colorimetric tests, showing high concentrations of polyphenols (up to 27.2 ± 1.5 mg GAE/g), flavonoids (up to 7.3 ± 0.5 mg QE/g) and iridoids (up to 40.8 ± 2.9 mg AE/g). The species were compared using HPLC-DAD-MS/MS, revealing some key differences in the phytochemical makeup of the extracts. The most abundant compound in the extracts of Galium verum blossoms and herb was found to be asperuloside, in Galium aparine herb, asperulosidic acid, and in Galium mollugo herb, chlorogenic acid. Additionally, the composition of volatile compounds was analysed by SPME-GC-MS. The degree of variability between the samples was high, but three volatiles, hexanal, anethole, and β-caryophyllene, were quantified (≥1%) in all analysed samples. The antioxidative activity of all extracts was evaluated using the ORACFL method, demonstrating that the Galium species from Estonia all exhibit strong antioxidant capacity (up to 9.3 ± 1.2 mg TE/g). Out of the extracts studied, Galium verum blossoms contained the highest amounts of bioactives and had the strongest antioxidant capacity. Full article
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