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Plant Saponins

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 1979

Special Issue Editor

1. Department of Tea Science, Zhejiang University, Hangzhou 310058, China
2. Tea Research Institute, Zhejiang University, Hangzhou 310058, China
Interests: natural products; food functional ingredients; tea; bioactivity; health
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Saponins are a large group of natural triterpene or steroid glycosides and are widely distributed in various plants. They are not only involved in the communication, defense, and sensory regulation of plants but also possess various bioactivities including anti-cancer, anti-inflammation, anti-microorganism, antioxidation, modulation of the gastrointestinal system, neuroprotection, accumulation of pollutants by plants, foaming and detergence, etc. Interest in saponins has increased over the years due to their application potentials in medicine, food, agriculture, daily chemical, and other fields.

This Special Issue welcomes original research and reviews on all aspects of plant saponins, including but not limited to: biosynthesis and chemical synthesis, extraction and isolation, chemical structure, determination methods, bioactivities, applications, and toxicity.

Dr. Bo Li
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • saponin
  • biosynthesis
  • chemical synthesis
  • chemical structure
  • determination
  • bioactivities
  • application
  • toxicity

Published Papers (1 paper)

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Research

12 pages, 2451 KiB  
Article
Anti-Colon Cancer Activity of Dietary Phytochemical Soyasaponin I and the Induction of Metabolic Shifts in HCT116
by Xuewei Xia, Qianmin Lin, Ning Zhao, Jinzi Zeng, Jiajia Yang, Zhiyuan Liu and Riming Huang
Molecules 2022, 27(14), 4382; https://doi.org/10.3390/molecules27144382 - 08 Jul 2022
Cited by 6 | Viewed by 1564
Abstract
Dietary phytochemicals play an important role in the prevention and treatment of colon cancer. It is reported that group B of soyasaponin, derived from dietary pulses, has anti-colonic effects on some colon cancer cell lines. However, it is uncertain which specific soybean saponins [...] Read more.
Dietary phytochemicals play an important role in the prevention and treatment of colon cancer. It is reported that group B of soyasaponin, derived from dietary pulses, has anti-colonic effects on some colon cancer cell lines. However, it is uncertain which specific soybean saponins play a role. In our study, as one of the group B soyasaponin, the anti-colon cancer activity of soyasaponins I (SsI) was screened, and we found that it had the inhibitory effect of proliferation on colon cancer cell lines HCT116 (IC50 = 161.4 μM) and LoVo (IC50 = 180.5 μM), but no effect on HT29 between 0–200 μM. Then, nine potential targets of SsI on colon cancer were obtained by network pharmacology analysis. A total of 45 differential metabolites were identified by metabolomics analysis, and the KEGG pathway was mainly enriched in the pathways related to the absorption and metabolism of amino acids. Finally, molecular docking analysis predicted that SsI might dock with the protein of DNMT1, ERK1. The results indicated that the effect of SsI on HCT116 might be exerted by influencing amino acid metabolism and the estrogen signaling pathway. This study may provide the possibility for the application of SsI against colon cancer. Full article
(This article belongs to the Special Issue Plant Saponins)
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