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Metabolites of Biofunctional Interest from Plant Sources

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 1263

Special Issue Editors


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Guest Editor
Instituto Politécnico Nacional–ENCB, U.P.A.L.M., San Pedro Zacatenco, Ciudad de Mexico 07738, Mexico
Interests: aloe vera; polysaccharides; antioxidant capacity; functional food; Biomacromolecules of plant origin; bioactive peptides; evaluation of antioxidant activity

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Guest Editor
Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Av. Wilfrido Massieu Esq. Manuel Stampa, Gustavo A. Madero, Ciudad de Mexico C.P. 11340, Mexico
Interests: antioxidant activity; plant biotechnology; food science; proteins; bioactivity; phenolic compounds; antioxidants; seeds; anthocyanins

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Guest Editor
Departmento Tecnología de Alimentos, INIA-CSIC, Ctra. de La Coruña km 7.5, 28040 Madrid, Spain
Interests: bioactive compounds; novel food product legume-based; processed legumes; animal and human nutrition
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

As is known, biofunctional metabolites with biological activity are widely distributed in plants. Increasing numbers of researchers have reported results confirming that plant metabolites have antioxidant, anti-inflammatory, antibacterial, anticancer, and other biological activities that contribute to good health and fight against diseases. Therefore, biofunctional plant metabolites are widely used in cosmetics and pharmaceutical industries, especially post-COVID-19.

In this Special Issue, researchers are invited to contribute original research and review articles that cover all topics related to the extraction, chemical analysis, and assessment of the biological activity of plant metabolites. Potential topics include (but are not limited to) the following: the biological activity of plant metabolites; the biological activity of plant extracts; plants as active ingredients in cosmetics; plants as dietary nutrients; the effects of different environments on the chemical composition of plant metabolites.

Dr. Rosalva Mora-Escobedo
Dr. Cristian Jiménez Martínez
Dr. Mercedes Martín Pedrosa
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • plant metabolites
  • biological activity
  • medicinal plants
  • functional plants
  • plant extracts

Published Papers (1 paper)

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Research

18 pages, 19695 KiB  
Article
Identification of the Microbial Transformation Products of Secoisolariciresinol Using an Untargeted Metabolomics Approach and Evaluation of the Osteogenic Activities of the Metabolites
by Wen-Xuan Yu, Hok-Him Tang, Jun-Jie Ye, Hui-Hui Xiao, Chung-Yan Lam, Tim-Fat Shum, Zhi-Kang Sun, Yuan-Zhen Li, Xin-Yu Zang, Wen-Chao Du, Jian-Ping Zhang, Tsz-Hung Kong, Li-Ping Zhou, Jia-Chi Chiou, Chun-Fai Kung, Kam-Wah Mok, Jing Hu and Man-Sau Wong
Molecules 2023, 28(15), 5742; https://doi.org/10.3390/molecules28155742 - 29 Jul 2023
Viewed by 976
Abstract
Secoisolariciresinol (SECO) is one of the major lignans occurring in various grains, seeds, fruits, and vegetables. The gut microbiota plays an important role in the biotransformation of dietary lignans into enterolignans, which might exhibit more potent bioactivities than the precursor lignans. This study [...] Read more.
Secoisolariciresinol (SECO) is one of the major lignans occurring in various grains, seeds, fruits, and vegetables. The gut microbiota plays an important role in the biotransformation of dietary lignans into enterolignans, which might exhibit more potent bioactivities than the precursor lignans. This study aimed to identify, synthesize, and evaluate the microbial metabolites of SECO and to develop efficient lead compounds from the metabolites for the treatment of osteoporosis. SECO was fermented with human gut microbiota in anaerobic or micro-aerobic environments at different time points. Samples derived from microbial transformation were analyzed using an untargeted metabolomics approach for metabolite identification. Nine metabolites were identified and synthesized. Their effects on cell viability, osteoblastic differentiation, and gene expression were examined. The results showed that five of the microbial metabolites exerted potential osteogenic effects similar to those of SECO or better. The results suggested that the enterolignans might account for the osteoporotic effects of SECO in vivo. Thus, the presence of the gut microbiota could offer a good way to form diverse enterolignans with bone-protective effects. The current study improves our understanding of the microbial transformation products of SECO and provides new approaches for new candidate identification in the treatment of osteoporosis. Full article
(This article belongs to the Special Issue Metabolites of Biofunctional Interest from Plant Sources)
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