Special Issue "Research of Organic Chemicals for Biological Applications"
Deadline for manuscript submissions: 31 October 2023 | Viewed by 8466
Interests: medicinal chemistry; organic chemistry; synthesis of sigma and 5-HT1A/5-HT7 selective receptors ligands; DAT and HDAC6 inhibitors; NMR; HPLC-MS; FT-IR analyses
Interests: medicinal chemistry; characterization of chiral compounds; CADD, design and synthesis of sigma receptors ligands with neuroprotective activity; anticancer agents acting as proteasome inhibitors or RNA-Binding protein disruptors; antimicrobial resistance; antiparasitic drugs
Drugs are chemicals used for medicinal purposes. They interact with complex chemical systems of humans. For this reason, organic chemicals and biology are closely related and the role of chemistry in the discovery and manufacture of new drugs is crucial.
This Special Issue covers research in medicinal chemistry, organic synthesis and analytical chemistry, useful for the rational design, synthesis and characterization of small molecules endowed with biological activity, in particular of pharmaceutical relevance.
Contributions on the most interesting developments in the organic chemistry, medicinal chemistry and chemical biology areas are welcome. These should concern:
- The rational design and structural optimization of hits and leads (i.e., computational, chemical, biophysical sciences), and the application of these technologies to the modern pharmaceutical research;
- The support of organic chemistry to the identification of new molecular targets through the synthesis of small molecule modulators that could be modulators of characterized (structure-based drug design, SBDD), or non-characterized biological targets (ligand-based drug design, LBDD);
- The development of advanced synthetic methodologies (such as organo-catalyzed, stereo-controlled, solvent-free, high pressure and microwave assisted synthetic procedures) and chemical technologies (such as flow chemistry, electrochemistry, photocatalysis), which directly affect the synthesis of new drug-like molecules or simply of new chemical entities. Particular attention will be paid to the development and application of environmentally sustainable synthetic techniques in view of the current global green transition;
- The application of advanced spectroscopic and spectrometric techniques (NMR, LC-(HR)MS, UV, and FT-IR) useful to structurally characterize the synthesized new organic molecules, to study the ligand-receptor interactions, and to develop the new biologically active molecules that have been discovered.
Full papers, communications, reviews and mini-reviews are welcome in this Special Issue.
Dr. Claudia Sorbi
Dr. Pasquale Linciano
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- medicinal chemistry
- organic chemistry
- organic synthesis
- biological targets
- drug design
- drug analysis
- pharmaceutical analysis.