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Molecules
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Natural Products in Counteracting Oxidative Stress and Inflammation
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Natural Products in Counteracting Oxidative Stress and Inflammation

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: 30 November 2024 | Viewed by 2012

Special Issue Editors

Prof. Dr. Qi-Dong You

E-Mail Website
Guest Editor
State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China
Interests: design and synthesis of bioactive compound; synthesis and modification of natural product; drugability optimization
Special Issues, Collections and Topics in MDPI journals
Dr. Zhengyu Jiang

E-Mail Website
Guest Editor
Department of Pharmacy, China Pharmaceutical University, Nanjing 211198, China
Interests: therapetiuc agents targeting Keap1-Nrf2-ARE signaling; redox system-related prodrugs and probes; innovative molecules acting on protein complex; E3 ligase complex
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Oxidative stress and inflammation, induced by oxidative imbalance, are widely recognized as key components of the pathogenesis of various chronic diseases. Rebalancing the redox state could be a promising strategy to counteract chronic diseases. However, the drug discovery campaign could be complicated. The redox-rebalancing agent may induce imbalance. For example, an antioxidant overdose could cause reductive stress. Moreover, some antioxidants also show oncogenic effects. Understanding how to identify a validated lead compound would be the main hurdle in this field. Natural products could be the answer. Natural products are a major source for drug discovery. In counteracting oxidative stress and inflammation, the multiple targets and biosynthesis characterstics of natural products could be beneficial.

This Special Issue aims to collect research articles and review papers dealing with all aspects of natural products in counteracting oxidative stress and inflammation. Papers describing the identification of new compounds and the discovery of new applications of well-known natural products will be especially welcome. Review papers about the relevant fields will also be favored.

Prof. Dr. Qi-Dong You
Dr. Zhengyu Jiang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural products
  • anti-inflammation
  • oxidative stress
  • antioxidant
  • free radicals
  • redox reaction
  • oxidative imbalance

Published Papers (2 papers)

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Research

16 pages, 10443 KiB  
Article
Hazel Leaf Polyphenol Extract Alleviated Cisplatin-Induced Acute Kidney Injury by Reducing Ferroptosis through Inhibiting Hippo Signaling
by Mingyang Sun, He Chang, Fangyang Jiang, Wenjing Zhang, Qingxuan Yang, Xinhe Wang, Guangfu Lv, He Lin, Haoming Luo, Zhe Lin and Yuchen Wang
Molecules 2024, 29(8), 1729; https://doi.org/10.3390/molecules29081729 - 11 Apr 2024
Viewed by 277
Abstract
Derived from hazelnuts, hazel leaf has been utilized in traditional folk medicine for centuries in countries such as Portugal, Sweden, and Iran. In our previous investigations, we conducted a preliminary assessment of the hazel leaf polyphenol extract (referred to as ZP) and identified [...] Read more.
Derived from hazelnuts, hazel leaf has been utilized in traditional folk medicine for centuries in countries such as Portugal, Sweden, and Iran. In our previous investigations, we conducted a preliminary assessment of the hazel leaf polyphenol extract (referred to as ZP) and identified nine compounds, such as kaempferol and chlorogenic acid, in its composition. ZP has shown promising properties as an antioxidant and anti-inflammatory agent. Our research has revealed that ZP has protective effects against cisplatin-induced acute kidney injury (AKI). We conducted a comprehensive examination of both the pathological and ultrastructural aspects and found that ZP effectively ameliorated renal tissue lesions and mitigated mitochondrial damage. Moreover, ZP significantly suppressed malondialdehyde levels while increasing glutathione and catalase concentrations in the kidneys of AKI-induced mice. ZP decreased the number of apoptotic cells and decreased pro-apoptotic protein expression in the kidneys of mice and human renal tubular epithelial cells (HK-2). Furthermore, treatment with ZP increased the levels of proteins marking anti-ferroptosis, such as GPX4, FTH1, and FSP1, in experiments both in vivo and in vitro. We elucidated the underlying mechanisms of ZP’s actions, revealing its inhibitory effect on Yap phosphorylation and its regulation of Lats expression, which exert a protective influence on the kidneys. Furthermore, we found that inhibiting the Hippo pathway compromised ZP’s nephroprotective effects in both in vitro and in vivo studies. In summary, this research shows that ZP exhibits renoprotective properties, effectively reducing oxidative damage, apoptosis, and ferroptosis in the kidneys by targeting the Hippo pathway. Full article
(This article belongs to the Special Issue Natural Products in Counteracting Oxidative Stress and Inflammation)
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18 pages, 3366 KiB  
Article
Phenolics Extracted from Jasminum sambac Mitigates Diabetic Cardiomyopathy by Modulating Oxidative Stress, Apoptotic Mediators and the Nfr-2/HO-1 Pathway in Alloxan-Induced Diabetic Rats
by Urooj Umar, Sibtain Ahmed, Asra Iftikhar, Maryam Iftikhar, Wafa Majeed, Atika Liaqat, Sana Shahzad, Mateen Abbas, Tahir Mehmood and Farooq Anwar
Molecules 2023, 28(14), 5453; https://doi.org/10.3390/molecules28145453 - 17 Jul 2023
Viewed by 1398
Abstract
Diabetes mellitus is a chronic metabolic disorder defined as hyperglycemia and pancreatic β-cell deterioration, leading to other complications such as cardiomyopathy. The current study assessed the therapeutic effects of phenolic acids extracted from Jasminum sambac phenols of leaves (JSP) against diabetes-induced cardiomyopathy in [...] Read more.
Diabetes mellitus is a chronic metabolic disorder defined as hyperglycemia and pancreatic β-cell deterioration, leading to other complications such as cardiomyopathy. The current study assessed the therapeutic effects of phenolic acids extracted from Jasminum sambac phenols of leaves (JSP) against diabetes-induced cardiomyopathy in rats. The rats were divided into four groups, with each group consisting of 20 rats. The rats were given intraperitoneal injections of alloxan monohydrate (150 mg/kg) to induce diabetes. The diabetes-induced groups (III and IV) received treatment for six weeks that included 250 and 500 mg/kg of JSP extract, respectively. In the treated rats, the results demonstrated that JSP extract restored fasting glucose, serum glucose, and hyperlipidemia. Alloxan induced cardiomyopathy, promoted oxidative stress, and altered cardiac function biomarkers, including cardiac troponin I, proBNP, CK-MB, LDH, and IMA. The JSP extract-treated rats showed improved cardiac function indicators, apoptosis, and oxidative stress. In diabetic rats, the mRNA expression of caspase-3, BAX, and Bcl-2 was significantly higher, while Bcl-2, Nrf-2, and HO-,1 was significantly lower. In the treated groups, the expression levels of the BAX, Nrf-2, HO-1, Caspase-3, and Bcl-2 genes were dramatically returned to normal level. According to our findings, the JSP extract prevented cardiomyopathy and heart failure in the hyperglycemic rats by improving cardiac biomarkers and lowering the levels of hyperlipidemia, oxidative stress, apoptosis, hyperglycemia, and hyperlipidemia. Full article
(This article belongs to the Special Issue Natural Products in Counteracting Oxidative Stress and Inflammation)
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